Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Amyloid Precursor-Like"”.
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Funktionelle Charakterisierung der synaptischen Transmission in APP/APLP1/APLP2-defizienten Mäusen
APP (Amyloid Precursor Protein) und APLP (Amyloid Precursor Like Protein) sind homologe Proteine, deren physiologische Funktion nur sehr unvollständig geklärt ist. Die Proteinfamilie ist synaptisch lokalisiert und wird durch Sekretasen in ähnlicher Weise prozessiert. Einem Spaltprodukt des APP, dem …
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Post-translational processing of proteins implicated in the pathogenesis of Alzheimer's disease.
The beta-amyloid peptide characteristic of the lesions of Alzheimer's disease (AD) is derived from the amyloid precursor protein (APP), a single transmembrane-spanning protein with several alternatively-spliced variants, some of which contain a Kunitz protease inhibitory (KPI) domain. Although …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… U.S. AD is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The b-amyloid peptide is the major component of the plaques and is produced as a cleavage byproduct of the amyloid precursor protein (APP). APP family proteins are present in mammals and the …
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Expression and Transcriptional Regulation of APL-1, a <i>Caenorhabditis elegans</i> APP Ortholog
<p>Alzheimer’s Disease (AD) is a devastating neurodegenerative condition that affects 6.7 million Americans annually and leads to memory loss and other cognitive impairments. There is currently no cure for the disease and current drugs only slow its onset. AD shares many overlapping symptoms with …