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Showing 1 to 20 of 62 for “"Amphotericin B"”.
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Structure and function of amphotericin B aggregates
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Membranous sterol dynamics and interactions with amphotericin B
… that determine the sterol-specificity to Amphotericin B (AmB), a powerful antifungal drug used to treat life threatening fungal infections. AmB forms large aggregates that are neither crystalline nor soluble, so structural information is difficult or impossible to obtain via x-ray …
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Solution and solid-state NMR studies of amphotericin B
Since its discovery in 1955, amphotericin B (AmB) has been a vital clinical agent. It remains the drug of last resort for systemic fungal infections despite its significant toxicity. Despite over 50 years of clinical use, very few cases of AmB resistance have been reported. This lack of resistance …
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Amphotericin B extracts ergosterol faster than fungi can make it
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Amphotericin B ion channels restore cystic fibrosis airway surface physiology
… production, such as cystic fibrosis (CF). Amphotericin B (AmB) is a natural product known to self-assemble into nonspecific ion channels in sterol-containing lipid membranes. It was long believed that AmB killed yeast through its inherent ion channel activity, existing primarily in the form …
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Semisynthesis of amphotericin B and its derivatives via iterative cross-coupling
… of investigation, the mechanism of action of amphotericin B (AmB), a potent but toxic antimycotic, has eluded the scientific community. The leading hypothesis involves insertion into the lipid bilayer of fungal cells followed by self-assembly into ion permeable channels that disrupt the …
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The ultrastructure of Torulopsis Glabrata and morphological changes induced by amphotericin B
Thesis (M.S.)--Michigan State University. Department of Pathology, 1976
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Elucidation of the mycosamine dependent sterol binding and antifungal activities of amphotericin B
Amphotericin B (AmB) is a clinically vital, yet highly toxic antifungal agent that is dependent on the presence of membrane sterols to exert its biological activity. This natural product has been shown to form ion channels in model membrane systems and therefore represents a molecule with the …
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A synthesis enabled understanding of Amphotericin B leading to derivatives with improved therapeutic indices
… and safe and effective new therapies. Although Amphotericin B (AmB) has served as the last line of defense against invasive fungal infections without significant pathogen resistance, its clinical application is restricted by severe dose-limiting toxicity. Efforts to improve AmB’s therapeutic …
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Part I: synthesis and cross-coupling of the C1-C12 primary organoborane building block of amphotericin B; Part II: site- and stereoretentive cross-coupling of unactivated secondary boronic acids inspired by amphotericin B
… of clinically valuable polyene natural product amphotericin B (AmB). In our retrosynthetic analysis, AmB is disconnected into four bifunctional building blocks and these building blocks are assembled via an iterative deprotection/cross-coupling fashion. Boronic acid-based cross-coupling …
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Development of second-generation amphotericin B molecular prosthetics for enhanced therapeutic efficacy in cystic fibrosis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Non-ionic surfactant vesicles as an Amphotericin B inhaled delivery system for the treatment of leishmaniasis
Amphotericin B (AmB) is a drug used to treat visceral leishmaniasis and fungal infections. Current available AmB formulations are limited by instability at tropical temperature, parenteral administration, renal toxicity (Fungizone®) or cost (AmBisome®, Amphotec® and Abelcet®). In this study, …
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Slow-release cross-coupling and an advanced method for β-glycosylation: methods stimulated by amphotericin B
Amphotericin B (AmB) represents a clinically vital but toxic antibiotic that additionally has the ability to form ion channels in biological membranes, a capacity normally associated with proteins. Better understanding the dynamics of channel formation and how it relates to AmB’s antifungal …
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Less toxic yet still resistance evasive amphotericins and atomistic probing of the amphotericin B ion channel
Amphotericin B (AmB) is a polyene macrolide natural product with two major functions: antifungal activity and ion channel formation. For over 50 years AmB has remained the last line of defense against systemic fungal infections. Remarkably, AmB has evaded the development of drug resistance during …
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Development and evaluation of amphotericin B Loaded iron oxide nanoparticles for targeted drug delivery to systemic fungal infections
… serum albumin (BSA), loaded and targeted with amphotericin B (AMB) (AMB-IONP) was formulated by applying a layer by layer approach. Several designs (A, B, C, D, & E) of AMB-IONP were developed and their physicochemical properties such as drug loading with HPLC method, particle size, poly …
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Synthesis-enabled understanding of the mechanism of action of amphotericin B and the development of increased therapeutic derivatives
Made available in DSpace on 2016-11-10T18:27:09Z (GMT). No. of bitstreams: 3 ENDO-THESIS-2016.pdf: 7095080 bytes, checksum: b07c6c85e5aa8667b9570e70f3813d47 (MD5) Master Thesis Endo.docx: 6914658 bytes, checksum: 4998e6a3b573682cb9a64d09793fa26d (MD5) LICENSE.txt: 4209 bytes, checksum: …
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Application of NMR spectroscopy to interrogate the structures of bacterial protein toxin membrane localization domains and amphotericin B
… set of studies addresses the antifungal drug amphotericin B (AmB). AmB is a natural product expressed by Streptomyces nodosus and has been used for over fifty years as an antifungal drug. Through its long use, it has evaded antimicrobial resistance. However, because of its high toxicity to …
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Studies using luciferase-expressing Leishmania donovani parasites
… in these studies i.e. sodium stibogluconate, amphotericin B, miltefosine and paromomycin. Intraperitoneal or bone marrow derived macrophages infected with L. donovani were incubated with different concentrations of each drug (sodium stibogluconate, 4-0.02mg/ml; amphotericin B, 4-0.02μg/ml: …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… sustained manner.<br/><br/><br/>In this thesis, amphotericin B, a model poorly soluble drug, was formulated using polymeric microneedle systems to achieve localised, long-acting intradermal delivery. Implantable microneedle systems and a dissolving microneedle system with reduced-size particles …
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Developing novel drug combinations for treatment of invasive fungal infections
… against azole (fluconazole) and polyene (amphotericin B) antifungals. Here, we utilized the combinatorial strategy to screen ~3400 FDA-approved drugs and clinical compounds to identify hits that can enhance/restore the antifungal activity of azoles and amphotericin B against resistant C. …
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