Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Amphiregulin"”.
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Amphiregulin (areg) And Epidermal Growth Factor (egf): Disparate In Egfr Signaling And Trafficking
<p>We have previously shown that SUM-149 human breast cancer cells require an AREG/EGFR autocrine loop for cell proliferation. We also demonstrated that AREG can increase EGFR stability and promote EGFR localization to the plasma membrane. In the presented dissertation we successfully knocked-down …
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Regulation der Progesteron-Rezeptor-Isoformen A und B im humanen Endometrium und ihr Einfluss auf spezifische Zielgene (Amphiregulin und Calcitonin)
… investigated. In addition, the expression of amphiregulin and calcitonin, two candidate markers which are regulated by the PR A isoform in the mouse model, were studied throughout the menstrual cycle. Material & Methods: An antibody specific for PR-B (Ab-6) and an antibody specific for PR-A …
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SOMATIC SIGNALS REGULATING MRNA TRANSLATION IN MAMMALIAN OOCYTE.
… oocytes exposed to the EGF-like growth factor, amphiregulin (GSE46640). Notably, one bovine dataset showed a significant correlation with EGF network activation, supporting, at least in part, the observation that IVM conditions might affect mRNA translation. Secondly, to experimentally confirm …
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Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization
… and regulatory T cells, resulting in increased amphiregulin secretion and tissue repair. In influenza-infected children, IL-17A, IL-33, and amphiregulin expression were positively correlated, and increased IL-17A levels in nasal aspirates were associated with better clinical outcomes. Our …
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Neutrophil Regulation of Colitis
… signaling in IECs enhancing the production of amphiregulin (AREG), a member of EGFR ligand family. Upon the induction of an intestinal inflammatory state, AREG signals through the EGFR pathway to induce epithelial junction formation, as a way to restore epithelial function and ameliorate …
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The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer
… expression of the cancer-related genes encoding amphiregulin and indoleamine 2, 3-dioxygenase. In the uterus, there were no differences detected in wet weight, luminal epithelial height, and proliferation. Also, there was no effect on serum E2 or P4 levels; however, EPMRT increased the time in …
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Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression
… up regulated expression of the growth factor Amphiregulin (AREG) and its receptor EGFR. Introduction of an expression plasmid encoding TPα into another PCa cell line, PC3 (PC3-TPα), led to a similar phenotype in response to IBOP, thereby confirming a link between TPα and over expression of …
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Innate immunity in defence against infection and tissue repair of the urinary tract
… bacterial cystitis and (ii) macrophage-derived amphiregulin (AREG) in acute pyelonephritis and infection-mediated scarring. Here, we identify type 17 immune response genes amongst the most up-regulated networks in the mouse bladder following UPEC challenge and identified ILC3s as a major source …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… EGF. Saturating doses of the two EGFR ligands, amphiregulin (AREG) and transforming growth factor-α (TGF-α), differentially triggered EGFR/CD147 internalization via NCE: while AREG efficiently activated NCE and Ca2+ release at the PM, TGF-α was less effective at triggering this pathway. This …
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Influence of chemical and mechanical stress on precision-cut lung slices
… by the slicing process. Stretch markers like amphiregulin were upregulated in PCLS by the slicing process. This upregulation was dependent on tyrosin kinases and the cytoskeleton, but could not be blocked sufficiently, which made it complicated to differentiate a stretch response from the …
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Stem Cell-Based Immune Modulation and Regeneration
… exposure to external stimuli. AEC-derived amphiregulin (AREG)/EGFR axis was identified as a key intracellular pathway in regulating immune responses. The activation of this powerful immune-modulatory factor is controlled through the COX-2/PGE2/EP4 axis, which can be activated from different …
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Group 2 innate lymphoid cells and reproduction
… and growth factors (i.e. IL-4, IL-5, IL-13, and Amphiregulin). Based on these premises, I hypothesized that uterine ILC2s (uILC2s) regulate uterine immune homeostasis and thus contribute to successful reproduction. To test this, I first characterised the uILC subtypes present in humans and mice …
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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… defining gene of the transcriptional profile was amphiregulin (AREG). When quantified, T cells from subjects with a viral lower respiratory tract infection (LRTI) that did not progress to moderate or severe pARDS had significantly elevated repair scores. This was reflected within tissue resident …