Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Amphiregulin"”.
-
Amphiregulin (areg) And Epidermal Growth Factor (egf): Disparate In Egfr Signaling And Trafficking
<p>We have previously shown that SUM-149 human breast cancer cells require an AREG/EGFR autocrine loop for cell proliferation. We also demonstrated that AREG can increase EGFR stability and promote EGFR localization to the plasma membrane. In the presented dissertation we successfully knocked-down …
-
SOMATIC SIGNALS REGULATING MRNA TRANSLATION IN MAMMALIAN OOCYTE.
… oocytes exposed to the EGF-like growth factor, amphiregulin (GSE46640). Notably, one bovine dataset showed a significant correlation with EGF network activation, supporting, at least in part, the observation that IVM conditions might affect mRNA translation. Secondly, to experimentally confirm …
-
Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization
… and regulatory T cells, resulting in increased amphiregulin secretion and tissue repair. In influenza-infected children, IL-17A, IL-33, and amphiregulin expression were positively correlated, and increased IL-17A levels in nasal aspirates were associated with better clinical outcomes. Our …
-
Neutrophil Regulation of Colitis
… signaling in IECs enhancing the production of amphiregulin (AREG), a member of EGFR ligand family. Upon the induction of an intestinal inflammatory state, AREG signals through the EGFR pathway to induce epithelial junction formation, as a way to restore epithelial function and ameliorate …
-
The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer
… expression of the cancer-related genes encoding amphiregulin and indoleamine 2, 3-dioxygenase. In the uterus, there were no differences detected in wet weight, luminal epithelial height, and proliferation. Also, there was no effect on serum E2 or P4 levels; however, EPMRT increased the time in …
-
Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression
… up regulated expression of the growth factor Amphiregulin (AREG) and its receptor EGFR. Introduction of an expression plasmid encoding TPα into another PCa cell line, PC3 (PC3-TPα), led to a similar phenotype in response to IBOP, thereby confirming a link between TPα and over expression of …
-
Innate immunity in defence against infection and tissue repair of the urinary tract
… bacterial cystitis and (ii) macrophage-derived amphiregulin (AREG) in acute pyelonephritis and infection-mediated scarring. Here, we identify type 17 immune response genes amongst the most up-regulated networks in the mouse bladder following UPEC challenge and identified ILC3s as a major source …
-
REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… EGF. Saturating doses of the two EGFR ligands, amphiregulin (AREG) and transforming growth factor-α (TGF-α), differentially triggered EGFR/CD147 internalization via NCE: while AREG efficiently activated NCE and Ca2+ release at the PM, TGF-α was less effective at triggering this pathway. This …
-
Group 2 innate lymphoid cells and reproduction
… and growth factors (i.e. IL-4, IL-5, IL-13, and Amphiregulin). Based on these premises, I hypothesized that uterine ILC2s (uILC2s) regulate uterine immune homeostasis and thus contribute to successful reproduction. To test this, I first characterised the uILC subtypes present in humans and mice …
-
T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… defining gene of the transcriptional profile was amphiregulin (AREG). When quantified, T cells from subjects with a viral lower respiratory tract infection (LRTI) that did not progress to moderate or severe pARDS had significantly elevated repair scores. This was reflected within tissue resident …