Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Amphiphilic peptides"”.
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Peptide nanovesicles: supramolecular assembly of branched amphiphilic peptides
… synthesized a set of 15 and 23-residue branched, amphiphilic peptides that mimic phosphoglycerides in molecular architecture. They undergo supramolecular self-assembly and form solvent-filled, bilayer delineated spheres with 50-150 nm diameters (confirmed by TEM and DLS). Whereas weak hydrophobic …
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Self-assembly of aurfactant-like amphiphilic peptides made of natural amino acids
… the development and behavior of a new class of amphiphilic molecules made of peptides, which may be used for solubilization and stabilization of membrane proteins. The peptides have a hydrophilic head group and a hydrophobic tail and self-assemble in aqueous solution to form tubes, vesicles and …
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Self-assembling amphiphilic peptides: A novel approach to create new drug systems and three-dimensional scaffolds for tissue regeneration. A resourceful mine not yet fully explored
… molecule, such as palmitic acid, and facially amphiphilic peptides, which is made by proper sequence patterning of hydrophobic and hydrophilic amino acids. In chapter 2 I describe how a peptide amphiphile was designed, synthesized and tested on different types of cancer cell lines, and it …
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A Peptide-Based Platform for Displaying Antibodies to Engage T Cells
… system in vivo. The composite consists of two amphiphilic peptides, AEAEAKAKAEAEAKAK (referred to as "EAK") and AEAEAKAKAEAEAKAKHHHHHH ("EAKH6"). Spectroscopic analysis showed the two peptides integrated into a single structure. Prior to combination, conformational analysis revealed that EAKH6 …
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Analyzing Functional Interactions of Designed Peptides by NMR Spectroscopy
… report the analysis of two groups of synthetic peptides designed for two applications – broad bactericidal action and inhibition of protein-protein interactions in human cells. Novel amphiphilic peptides designed for antibacterial application incorporated arginine as cationic amino acids and …
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Myoglobin Microsperes and Metalloporphyrin -Peptide Complexes
… using disulfide-linked tweezers and cyclic peptides. The binding affinities, helicities, and mechanism of binding of linear, tweezers, and cyclic peptides to [Fe III(coproporphyrin-I)]+ have been determined. We have incorporated disulfide bridges between amphiphilic peptides to make …
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The activity of pH membrane disruptive pseudopeptides and their subcellular fate in mammalian cells cultured in-vitro
This thesis describes investigations upon pseudopeptides which were conducted to improve our understanding of the fate of synthetic macromolecules in cells and to develop approaches to influence that fate. The low uptake of molecules across the external cellular membrane is the principal barrier …
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Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
… synthesized a novel group of linear and cyclic amphiphilic peptides containing different sequences of arginine (R) and tryptophan (W) residues. The peptides included a class of cyclic peptides, [R3W3]2, [R3WRW]2, [RWW]4, [WRR]4, [RWRW3]2, and the corresponding linear peptides, (R3WRW)2, (RWW)4, …
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Regulating the Biomedical and Biocatalytic Properties of Amphiphilic Self-assembling Peptides via Supramolecular Nanostructures
… or induced by environmental factors. Peptides, short chains of amino acids, can self-assemble into many types of nanostructures. The self-assembly of peptides is governed by noncovalent interactions, including electrostatic interactions, hydrogen bonding, hydrophobic interactions, …