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Showing 1 to 20 of 54 for “"Amphiphile"”.
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Lattice models of amphiphile and solvent mixtures.
… of a three dimensional lattice model of an amphiphile and solvent mixture has been developed as an extension of earlier work in two dimensions. In the earlier investigation the simulation was carried out with three segment amphiphiles on a two dimensional lattice and cluster size …
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Synthesis, Characterization, and Utilization of Polyol Amphiphile Molecules
Polyol amphiphiles were synthesized with various hydroxyl chain lengths and hydrophobic moieties, including oleyl and oligo(styrene). These novel amphiphiles are predictably hygroscopic, forming lyotropic liquid crystals upon exposure to water. The resulting lamellar and hexagonal mesophases were …
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Amphiphile Polymere als Transfektionssysteme : Synthese und in vitro Gentransfer
In dieser Arbeit wird ein neues Konzept von Gentransfer untersucht. Polymere, die an einem Teil die DNA ionisch binden und mit dem anderen Teil Zellmembranen kurzzeitig permeabilisieren und danach die DNA in die Zielzelle einschleusen, werden synthetisiert. Drei Tenside werden mit …
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Amphiphile self-assembly and phase evolution in reactive environments
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Amphiphile Polyurethan-Makromere als Emulgatoren und Comonomere für die heterophasige Polymerisation hydrophober Monomere
… die Synthese und Charakterisierung von amphiphilen Polyurethanen mit Emulgatoreigenschaften für die Polymerisation hydrophober Monomere in wässriger Phase. Der Emulgator wurde mit kolloid- und polymerchemischen Methoden hinsichtlich seiner grenzflächenaktiven Eigenschaften sowie einer …
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A computer-simulation-based molecular-thermodynamic model for shape-based screening of peptide amphiphile micelles in vaccines
Peptide amphiphiles (PAs) and their self-assembled aggregates, peptide amphiphile micelles (PAMs), have garnered considerable attention as a platform for biomedical applications due to their unique combination of biocompatibility, modular functionality, and tailorable size and shape. Since PAMs …
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Computer simulation of micelle self-assembly.
… from a three dimensional lattice model of amphiphile-solvent and amphiphile-amphiphile-solvent systems studied using Monte Carlo simulations. This model builds upon previous models [1-11] allowing for a longer am-phiphilic head group and the inclusion of a second, different amphiphile. …
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Synthesis, Characterization, and Antimicrobial Activity of Water-soluble, Tri-carboxylato Amphiphiles
… of biological activity in a homologous series of amphiphiles have shown a cut-off effect, where the biological activity increases with an increase in chain length, after which the activity plateaus or weakens. One factor suspected to cause this problem is solubility issues. We have designed …
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Engineering delivery systems for the treatment of Non-Hodgkin lymphoma
… Lipidation of peptides, producing peptide amphiphiles, has been shown to allow for hydrophobically-driven self-assembly into peptide amphiphile micelles. There are many advantages to employing peptide amphiphile micelles as drug delivery devices, including improved serum stability, higher …
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Grenzflächen-kontrollierte Mineralisation von Calciumphosphat
… gezeigt werden, dass die beiden verwendeten Amphiphile mit Cholesterol als hydrophoben Block, gute Template für die Mineralisation von Calciumphosphat an der Wasser/Luft-Grenzfläche sind. Mittels Infrarot-Reflexions-Absorptions-Spektroskopie (IRRAS), Röntgenphotoelektronenspektroskopie (XPS), …
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Synthesis, Characterization, Critical Micelle Concentration and Antimicrobial Activity of Two-headed Amphiphiles
… of homologous series of two-headed, long-chain amphiphiles (the 2CCbn series, where n = 16, 18, 20, 22, 30, 5α-cholestan-3Ã -ol). The 2CCbn series was synthesized in five steps. The first step involves a reaction of nitroethane and two equivalents of tert-butyl acrylate to form nitrodiester by …
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Supramolecular Nanostructures as Support Materials for Gold Nanoparticle Catalysts
… promising self-assembled molecule is the aramid amphiphile (AA), which overcomes the typical mechanical fragility of self-assembled structures by incorporating a Kevlar-inspired domain into its molecu- lar structure. In this work, we present a cysteine-functionalized aramid amphiphile platform …
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Anisotrope Hydrogele
… Phase wurden stäbchenförmige, formanisotrope Amphiphile verwendet, die ausschließlich eine lamellare Phase (L?) zeigen und eine polymerisierbare funktionelle Gruppe tragen. Es wurde ein neuer Vernetzertyp eingeführt, der entsprechend der Phasenstruktur der verwendeten Amphiphile angepasst war. …
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Design and Synthesis of a Macrocyclic Phospholipid
… synthesis. Two other phospholipids, a linear bolaamphiphile derived from the precursor to the second click reaction, and a linear amphiphile created from a glutarate bis-dodecyl ester, were also synthesized to provide controls for probing the orientation of the macrocyclic phospholipid in the …
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Self-assembling amphiphilic peptides: A novel approach to create new drug systems and three-dimensional scaffolds for tissue regeneration. A resourceful mine not yet fully explored
… two types of peptide-based structures: peptide amphiphiles, in which an amino acidic sequence is tailed with an hydrophobic molecule, such as palmitic acid, and facially amphiphilic peptides, which is made by proper sequence patterning of hydrophobic and hydrophilic amino acids. In chapter 2 I …
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Synthesis, characterization, and evaluation of photo-active amphiphiles for gene delivery applications
… The use of a charge-reversal or charge-switching amphiphile has been previously described by which the amphiphile initially has a net positive charge and is rendered negatively charged upon enzymatic removal of a terminal ester group. In order to further improve the transfection efficacy of …
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Small molecule motion within and through organic nanomaterials: an anthology
… pertains to self-assembled small-molecule aramid amphiphile (AA) nanostructures. AAs are noteworthy within the class of self-assembled amphiphile materials because of their unusual mechanical stability borne of strong intermolecular interactions between aramid units. In Chapter 2, I evaluate local …
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Design of ultra-robust supramolecular assemblies and their application to water treatment
… constructed from small molecule aramid amphiphiles to overcome these limitations. Aramid amphiphiles incorporate a Kevlarinspired domain that imparts strong, cohesive intermolecular interactions between molecules. This design results in the self-assembly of aramid amphiphiles into …
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Polyelectrolyte nanostructures formed in the moving contact line: fabrication, characterization and application
… structures were used as templates for assembling amphiphile molecules. Quasiperiodic aligned and oriented nanostructures of polyelectrolyte molecules formed in moving droplets were utilized for fabrication of electrically conductive one-dimensional nanowires.
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Synthesis of guanidinium-functionalized amphiphiles for the exploration of chaotropic supramolecular nanoribbons
… before breaking down. Aromatic amide (aramid) amphiphiles, which can form strong hydrogen bonding and pi-pi stacking between them, self-assemble into stable, mechanically strong nanofibers, in stark contrast to the assemblies that precede them. This study seeks to functionalize the aramid …
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