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Showing 1 to 20 of 72 for “"Amorphous solid"”.
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Dissolution Behavior of Amorphous Solid Dispersions
… drug. Solubility enhancement techniques, such as amorphous solid dispersions (ASDs), can be used in oral dosage forms to increase the apparent solubility of the drug in the gastrointestinal tract thus increasing the bioavailability of the drug. However, the drug solution generated from the …
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IMPROVED AMORPHOUS SOLID DISPERSION PERFORMANCE USING BINARY POLYMER COMBINATIONS
With increasing attrition rate of new molecular entities due to sub-optimum aqueous
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Evaluation and enhancement of physical stability of amorphous solid dispersions
… of poorly water-soluble drugs.[1],[2] The amorphous forms of APIs have attracted considerable attention as the amorphous forms tend to exhibit significantly higher levels of supersaturation in aqueous media when compared to the crystalline forms.[3],[4] For drugs which bioavailability is …
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Statistical mechanics of the amorphous solid state of randomly crosslinked macromolecules
… together with sulfur, he obtained an elastic solid material. This liquid-solid transformation was later found to entail the random crosslinking of the linear macromolecules forming natural rubber, until the crosslink density is high enough that an equilibrium phase transition--the …
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Structural Dynamics of Amorphous Solid-State Macromolecular Materials at Terahertz Frequencies
Structural Dynamics of Amorphous Solid-State Macromolecular Materials at Terahertz Frequencies Talia Amira Shmool The aim of this thesis is to investigate the ability of terahertz time-domain spectroscopy (THz-TDS) to study complex amorphous solid-state systems. THz-TDS is a vibrational optical …
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Mixed Polysaccharide Esters for Amorphous Solid Dispersion Oral Drug Delivery Vehicles
… properties. We designed very effective amorphous solid dispersion (ASD) oral drug delivery polymers that prevented recrystallization of felodipine for hours and had excellent congruent polymer-drug release from the formulation at 20% drug loading. During the ring-opening reactions of the …
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Amorphous solid dispersion effects on in vitro solution concentrations of quercetin
… to achieve this by incorporating quercetin into amorphous solid dispersions (ASDs) with cellulose derivatives, eliminating crystallinity, and selectively releasing amorphous quercetin under simulated intestinal conditions (pH 6.8, 37C). Amorphous quercetin was dispersed in cellulose esters …
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Modeling and Prediction of Amorphous Solid Dispersion Formation Using a Molecular Descriptor
… drug development. Delivering a drug in its amorphous solid-state is a potential method to overcome this issue, since the amorphous form has increased apparent aqueous solubility. However, the amorphous state is only metastable, and is thermodynamically driven to recrystallize. As a result, …
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Statistical Mechanics of the Amorphous Solid State of Randomly Cross-Linked Macromolecules
… theory of the elastic properties of the amorphous solid state is presented that accounts for both thermal fluctuations and quenched disorder. It is found that the shear modulus grows continuously from zero at the transition, and does so with the classical exponent, i.e., with the third …
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ACID-BASE INTERACTIONS IN AMORPHOUS SOLID DISPERSIONS: FORMULATION STRATEGY FOR TYROSINE KINASE INHIBITORS
Song, Yang. Ph.D., Purdue University, December 2015. Acid-base Interactions in
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Development and Evaluation of Ternary Amorphous Solid Dispersion of Poorly Water-soluble Compounds
Purpose: Ternary amorphous solid dispersion (TASD) containing an additional component compared to conventional binary ASD further enhances the effectiveness of this strategy. Recently, polyphenolic compounds such as curcumin (CUR) and resveratrol (RES) are shown to have synergistic antioxidant, …
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The Vulcanization Transition and the Amorphous Solid State It Yields: A Statistical Mechanical Perspective
… phase transition from the liquid to the amorphous solid state. In order to understand the origins and consequences of the universal aspects of this transition and the emergent solid state, we construct a minimal model in the spirit of the Landau approach to continuous phase transitions. …
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Nuclear Magnetic Resonance for the Characterisation of Hot-Melt Extruded Pharmaceutical Amorphous Solid Dispersions
… poor solubility. The formulation of drug/polymer amorphous solid dispersions (ASDs) is one of the most successful strategies for improving the oral bioavailability of poorly soluble APIs. Hot-melt extrusion (HME) is one method for preparing ASDs that is growing in importance in the pharmaceutical …
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Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics and dissolution kinetics in vitro
… by incorporating rifapentine into pH-responsive amorphous solid dispersions with cellulose derivatives including: hydroxypropylmethylcellulose acetate succinate (HPMCAS), cellulose acetate suberate (CASub), and 5-carboxypentyl hydroxypropyl cellulose (CHC). Most amorphous solid dispersions …
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Assessment of nanocomposites vs. amorphous solid dispersions for dissolution enhancement of bcs class ii drugs
… formulations (nanocomposites) and amorphous solid dispersions, shortly ASDs, are two major pharmaceutical formulation platforms used for the bioavailability enhancement of poorly water-soluble drugs. While they both have several advantages-disadvantages, a scientific comparative …
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A Dual Approach of Salt Formation and Amorphous Solid Dispersion for Improved Oral Drug Delivery
… solve this issue by combining salt formation and amorphous solid dispersion. Three weakly basic belonging to BCS class II drugs, clofazimine, aripiprazole, and haloperidol, were selected as model drugs. Ten salts of each drug were prepared with counterions with ΔpKa> 3 using a rotary evaporator …
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The effect of additives on the molecular mobility, physical stability and dissolution of amorphous solid dispersions
… compounds. However, crystallization of the amorphous phase during storage or dissolution could negate the solubility advantage. The objectives were to (i) develop an accelerated testing method for predicting the solid-state physical stability of drugs in amorphous solid dispersions (ASD), …
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Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
… in the treatment of prostatic carcinoma. FLT amorphous solid dispersions (SDs) and solid lipid nanoparticles (SLNs) were prepared to overcome limited solubility. Investigation of drug-polymer and drug-lipid miscibility was carried out to enhance drug performance by assessing solubility and …
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Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
… the performance of prepared or reported SDs (solid dispersions). Crystallization tendencies of five different drugs [i.e. Curcumin (CUR), indomethacin (IND), flutaminde (FLU), dipyridamole (DIP), griseofulvin (GRI)] in absence and presence of four different polymers [i.e. polyethylene glycol …
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