Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Amorphous Solid Dispersion"”.
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IMPROVED AMORPHOUS SOLID DISPERSION PERFORMANCE USING BINARY POLYMER COMBINATIONS
With increasing attrition rate of new molecular entities due to sub-optimum aqueous
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Mixed Polysaccharide Esters for Amorphous Solid Dispersion Oral Drug Delivery Vehicles
… properties. We designed very effective amorphous solid dispersion (ASD) oral drug delivery polymers that prevented recrystallization of felodipine for hours and had excellent congruent polymer-drug release from the formulation at 20% drug loading. During the ring-opening reactions of the …
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Amorphous solid dispersion effects on in vitro solution concentrations of quercetin
… to achieve this by incorporating quercetin into amorphous solid dispersions (ASDs) with cellulose derivatives, eliminating crystallinity, and selectively releasing amorphous quercetin under simulated intestinal conditions (pH 6.8, 37C). Amorphous quercetin was dispersed in cellulose esters …
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Modeling and Prediction of Amorphous Solid Dispersion Formation Using a Molecular Descriptor
… drug development. Delivering a drug in its amorphous solid-state is a potential method to overcome this issue, since the amorphous form has increased apparent aqueous solubility. However, the amorphous state is only metastable, and is thermodynamically driven to recrystallize. As a result, …
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Development and Evaluation of Ternary Amorphous Solid Dispersion of Poorly Water-soluble Compounds
Purpose: Ternary amorphous solid dispersion (TASD) containing an additional component compared to conventional binary ASD further enhances the effectiveness of this strategy. Recently, polyphenolic compounds such as curcumin (CUR) and resveratrol (RES) are shown to have synergistic antioxidant, …
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A Dual Approach of Salt Formation and Amorphous Solid Dispersion for Improved Oral Drug Delivery
… solve this issue by combining salt formation and amorphous solid dispersion. Three weakly basic belonging to BCS class II drugs, clofazimine, aripiprazole, and haloperidol, were selected as model drugs. Ten salts of each drug were prepared with counterions with ΔpKa> 3 using a rotary evaporator …
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Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery
The use of amorphous solid dispersions (ASDs) is an effective and increasingly widely adopted approach for solubility and bioavailability enhancement of hydrophobic drugs. Cellulose derivatives have strong potential as ASD polymers. We demonstrate herein design, synthesis and structure-property …
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Application of Hansen Solubility Parameters and Thermomechanical Techniques to the Prediction of Miscibility of Amorphous Solid Dispersion. Investigating the role of cohesive energy and free volume to predict phase separation kinetics in hot-melt extruded amorphous solid dispersion using dynamic mechanical analyser, shear rheometer and solubility parameters data
Hot-melt extruded solid dispersion technique is increasingly employed to improve the solubility of poorly water-soluble drugs. The technique relies on the enhanced solubility of the amorphous form of the drug compared to its crystalline counterpart. These systems however are thermodynamically …
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Evaluation and enhancement of physical stability of amorphous solid dispersions
… of poorly water-soluble drugs.[1],[2] The amorphous forms of APIs have attracted considerable attention as the amorphous forms tend to exhibit significantly higher levels of supersaturation in aqueous media when compared to the crystalline forms.[3],[4] For drugs which bioavailability is …
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Physical analysis of solid solution formulations
Amorphous solid dispersion is one of the techniques used for enhancing dissolution rate of drugs with low aqueous solubility. The physical stability of the amorphous solid dispersion is the main challenge for their formulation development and commercialisation by pharmaceutical industry. The aims …
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Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics and dissolution kinetics in vitro
… by incorporating rifapentine into pH-responsive amorphous solid dispersions with cellulose derivatives including: hydroxypropylmethylcellulose acetate succinate (HPMCAS), cellulose acetate suberate (CASub), and 5-carboxypentyl hydroxypropyl cellulose (CHC). Most amorphous solid dispersions …
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Regioselective chlorination of cellulose esters
… potentialiii for various applications, including amorphous solid dispersion, tight junction opening, anionic drug delivery, and gas separation membranes.
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Pullulan w-carboxyalkanoates for Drug Nanodispersions
… in drug delivery systems. Particularly in amorphous solid dispersion (ASD) formulations, hydrophobicity increases miscibility with hydrophobic, crystalline drugs and carboxy functionality provides stabilization with drug moieties and well as pH specific release. Successful synthesis of …
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Synthesis of Polysaccharide-based Biomaterials for Drug Delivery
… conjugates, pH-responsive hydrogels, and amorphous solid dispersion (ASD) polymers were developed. Conjugating a polysaccharide to a protein drug via a covalent bond may improve its medical properties including solubility, stability, immunogenicity, circulation time, and targeting ability. …
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Continuous manufacture of enabling formulations for a poorly soluble compound using hot melt extrusion technology
… technique in the production of oral solid dosage formulations, its operating capacity has the capability to address formulation and manufacturing issues associated with drugs which possess poor solubility, permeability and bioavailability. With traditional, batch-style manufacturing …
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Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems
Amorphous solid dispersion (ASD) is a popular method to increase drug solubility and consequently poor drug bioavailability. Cellulose ω-carboxyesters were designed and synthesized specifically for ASD preparations in Edgar lab that can meet the ASD expectations such as high Tg, recrystallization …
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The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations
… formulation design. In this respect, research on solid dispersion of hydrophilic carrier has commenced a decade ago to resolve the problem of poorly soluble drug. However, the availability of solid dispersion is commercially limited due to the concerns of its physical instability, unpredictability …
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Pharmaceuticals on the Nanoscale: Multi-dimensional Electron Diffraction of Organic Molecular Crystals
… defects which may enhance the understanding of solid-state behaviours which are key to drug development. Both of these techniques are able to reveal a wealth of structural information about a sample. As the next generation of dosage modalities include innovations in nanoengineering, access to …
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Synthesis of New Pullulan Derivatives for Drug Delivery
… degradation. We report herein a study on amorphous solid dispersion (ASD) of CLA with promising carboxyl-containing cellulose derivatives, both as macro and nanoparticles. This approach was intended to improve CLA solubility in neutral media, to protect it from acid degradation, and …
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Regioselective Synthesis of Polysaccharide-based Polyelectrolytes
… are promising for some applications such as amorphous solid dispersion (ASD) oral drug delivery.
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