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Showing 1 to 8 of 8 for “"Amiodarone"”.
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Amiodarone-induced pulmonary toxicity in F344 rats
Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to develop and characterize a rat model of amiodarone-induced pulmonary toxicity (AIPT). A protocol was developed …
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ΑΛΛΗΛΕΠΙΔΡΑΣΗ ΚΑΤΕΧΟΛΑΜΙΝΩΝ ΦΑΡΜΑΚΩΝ ΠΟΥ ΔΡΟΥΝ ΣΤΟΥΣ ΥΠΟΔΟΧΕΙΣ ΤΩΝ ΚΑΤΕΧΟΛΑΜΙΝΩΝ ΚΑΙ ΦΑΡΜΑΚΩΝ ΠΟΥ ΕΠΗΡΕΑΖΟΥΝ ΤΗΝ ΔΙΑΚΙΝΗΣΗ ΑΣΒΕΣΤΙΟΥ ΣΕ ΑΠΟΜΟΝΩΜΕΝΗ ΑΟΡΤΗ ΕΠΙΜΥΟΣ. ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΔΡΑΣΕΩΣ ΤΗΣ ΑΜΙΩΔΑΡΟΝΗΣ
… ISOLATED RAT AORTA, HAVING THE RESEARCH ON THE AMIODARONE'S ACTION AS THE REFERENT POINT. MORE SPECIFICALLY , IT STUDIES THE EFFECT OF NORADRENALINE, POTASSIUM CHLORIDE, SEROTONIN, AND OF PROSTAGLANDIN F2A ON THE PREPARATION, WHILE SIMULTANEUSLY, IT EXAMINES THE VASODILATOR ACTION OF AMIODARONE …
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Búsqueda de interacciones off-target usando el fármaco Amiodarona como caso de estudio
… was carried out with the antiarrhythmic drug Amiodarone, to find and report protein pockets responsible for producing off-target effects. Four notable adverse effects were obtained for this drug: hepatic steatosis, oxidative stress, metabolic acidosis/diuresis, and pulmonary toxicity. The …
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The precipitation of candidate drugs on mixing DMSO stock solutions with aqueous buffers
… commercially available drug molecules, namely amiodarone HCl, clotrimazole and tolnaftate. The work presented here assesses the process from a physical chemistry point of view. Upon mixing the DMSO drug stock and aqueous buffer, all three compounds form particulates in the nanometre size …
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Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases
… used medication for chronic diseases such as amiodarone, amitriptyline, and statins all caused altered mitochondrial dysfunction. In addition, cardiotoxic chemicals (isoproterenol, hydrogen peroxide, DOX) altered oxidative phosphorylation and glycolysis in living cardiomyocyte-derived H9c2 …
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Pharmacogenomics of warfarin: comprehensive evaluation of important warfarin genomic response factors
… factors (i.e., age, body surface area, amiodarone, race, targeted INR, smoking and thromboembolism). However, these studies have often excluded African populations, therefore missing variants that might be important in the prediction of warfarin doses among Africans. Data on variants …
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Einfluss der Antiarrhythmika Flecainid und Amiodaron auf die kontraktile Funktion und die Kraft-Frequenz-Beziehung des Herzens
Einleitung: Der plötzliche Herztod bei fortgeschrittener Herzinsuffizienz (HI) wird häufig durch tachykarde Rhythmusstörungen wie Vorhofflimmern verursacht. Dieser gehört zu den häufigsten Todesursachen der HI. Das Antiarrhythmikum Flecainid (Flec) gilt aufgrund seines negativ inotropen Effektes …
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Effekt von Amiodaron auf periphere Parameter der Schilddrüsenhormonaktivität bei kardiologischen Patienten mit AICD
Amiodaron ist ein hochpotentes Antiarrhythmikum, welches bei schweren, therapieresistenten ventrikulären Arrhythmien, aber auch bei Vorhofflimmern und Reentrytachykardien eingesetzt wird. Bezüglich des antiarrhythmogenen Effektes findet sich eine Verlängerung der Repolarisationszeit, wie bei …