Global ETD Search
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Showing 1 to 5 of 5 for “"Aminooxyacetic acid"”.
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Synthesis of Inhibitors of Cystathionine β-Synthase
… potential drug therapies for colorectal cancer. Aminooxyacetic acid (AOA) is an inhibitor of CBS, yet has a major limitation in that it is not selective and inhibits a variety of other PLP-dependent enzymes. To overcome this limitation, two AOA conjugates were synthesized in an attempt to deliver …
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Exploration of Hypotensive Effects of Novel Hydrogen Sulfide Donors: Mechanisms and Their Delivery
… mechanistic studies were conducted using aminooxyacetic acid (AOAA), an inhibitor of endogenous H2S synthesis, and glibenclamide (GLBN), a KATP channel blocker. These studies confirmed that both endogenous H2S production and the activation of KATP channels are crucial in mediating the …
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Effect of Hydrogen Sulfide Donors on Sympathetic Neurotransmission and Intraocular Pressure of the Eye
… the drugs, antagonists were used. These included aminooxyacetic acid (AOA), a cystathionine-β-synthase (CBS) inhibitor and glibenclamide, a KATP channel blocker. Although AOA (3mM) and glibenclamide (300 μM) had no effect (p>0.05) on [3H]NE release, they both reversed the inhibitory action of GYY …
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The effects of the modification of energy metabolism on cellular response to ionizing radiation
… (2DG), and an inhibitor of glutaminolysis, aminooxyacetic acid (AOA), were administered to CHO cells in vitro to determine the effects of these substances on cellular radiosensitivity and repair. Repair was assessed by means of a split radiation dose experiment. The design of such an …
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Inhibition of excitatory neurotransmitter activity by hydrogen sulfide in bovine retina, in vitro
… the Cystathionine β-synthase (CBS) inhibitor, aminooxyacetic acid (AOA; 3 mM) did not have an effect on basal K+-induced [3H]D-aspartate release. However, it completely reversed the inhibitory effects elicited by L-cysteine (1 µM and 10 µM) and GYY 4137 (1 µM and 10 µM) on the excitatory …