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Showing 1 to 20 of 20 for “"Aminolysis"”.
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Aminolysis of the 4-acetoxybenzoate anion catalysed by cyclodextrins
… effects of the three CDs on the kinetics of the aminolysis of 4-ABA by primary amines have been investigated. Rate constants for the nucleophilic attack by free and CD-bound amine are obtained. For Ì-CD, values of the reactivity ratios for the linear amines are low (<1) implying deceleration of …
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Development of a microwave-assisted epoxide aminolysis and investigation of the aza-cope rearrangement--mannich cyclization for alkaloid synthesis
… microwave heating reduces reaction times for the aminolysis of both reactive and unreactive, sterically hindered epoxides. These reactions were accomplished with various amines. In all cases, only one equivalent of amine and epoxide were needed to give good yields and modest to excellent …
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Substituted 2-ethyl-7-hydroxybenzisoxazolium salts in peptide synthesis and kinetic investigations on the aminolysis of N-acylamino acid p-nitrophenyl esters with various amino acid esters.
Massachusetts Institute of Technology. Dept. of Chemistry. Thesis. 1971. Ph.D.
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ENZYME ENGINEERING AND GREEN SYNTHESIS OF N-ACYL GLYCINE BIOSURFACTANTS FROM RENEWABLE RAW MATERIALS
… activation of fatty acids and their subsequent aminolysis with glycine to synthesize N-acyl glycines. We then engineer an enzyme (proRML) by reshaping its catalytic pocket to enhance its aminolysis activity and catalytic efficiency by 103-fold and 465-fold, respectively. The evolved proRML …
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Structure and reactivity of cyclic imido derivatives of phosphoric acid
… pv trigonal bipyramidal intermediate is reduced. Aminolysis of 22 with ammonia and p-anisidine resulted in products which indicate that nucleophilic attack takes place exclusively at the phosphorus atom. In the aminolysis with p-anisidine, both P-0 bond cleavage (displacement of phenol, 43) and …
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Microwave-assisted synthesis of ß-amino alcohols
… synthesize amino alcohols via microwave-assisted aminolysis of several hindered and unhindered epoxides using amine nucleophiles of varying strengths. Microwave reactions can be done without Lewis acids or promoters, even for the most hindered trisubstituted epoxides. In most of these cases, the …
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Part I. Anionic Acyl Transfer Catalysis;Part II. Enantioselective alcoholysis of Acyl Donors;Part III. Enantioselective N-acylation
… be an effective acyl transfer catalyst in both aminolysis and transesterification reactions. These findings pave the way to designing asymmetric anionic acyl transfer catalysts, which may be useful, e.g., for catalytic kinetic resolution of chiral amines.</p><p>From 2003 to 2009, our group …
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Synthesis and application of Fischer carbene complexes of group 6, 8 and 9 transition metals
… parent ethoxycarbene complex subsequent to the aminolysis processes were studied using various spectroscopic analysis approaches. Molecular structures of these complexes were confirmed by single-crystal X-ray diffraction. Complexes of Fe(0) and Co(I) adopted a trigonal-bipyramidal molecular …
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Synthesis of functionalised sulfonamides
… in a regio- and diastereoselective manner. Aminolysis of the resultant PFP sulfonate ester then provides functionalised sulfonamides of potential biological utility. In addition, the [3+2] cycloaddition reaction of several vinyl sulfonamides with N-methyl-nitrones is reported. …
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BIFUNCTIONAL BF2 COMPLEXES OF POLYDENTATE BIS(AMIDINATES): SYNTHESIS, STRUCTURES, AND PHOTOLUMINESCENCE PROPERTIES
… as a yellow oil in 86% yield. Subsequent aminolysis with 2-aminopyridine, 4-methyl-2-aminopyridine, 6-methyl-2-aminopyridine, 4,6-dimethyl-2-aminopyridine, and 2-aminoquinoline yielded the polydentate bis(amidines) as colorless solids (61−71%).</p> …
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Inorganic-Organic Sol-Gel Derived Hybrid Materials as Abrasion Resistant Coatings
… and abrasion resistance were investigated. An aminolysis mechanism was also proposed to explain the adhesion between sol-gel derived coatings and polycarbonate substrates promoted by a 3-aminopropyltriethoxysilane (3-APS) primer. FT-IR, GPC, 1H and 13C NMR, XPS experiments were conducted to …
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Borinic Acid-catalyzed Ring-opening of Epoxy Alcohols
… underpinnings of the catalytic cycle for the aminolysis of 3,4-epoxy alcohols. RPKA experiments using in situ reaction monitoring by NMR and ATR-IR spectroscopy are used to decipher the kinetic order dependences in catalyst and nucleophile. The derived rate law under catalyst inhibition by …
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Total synthesis of naturally occurring glycosylated tetramic acids
… of the sugar moiety, a HWE olefination, an aminolysis reaction to install the L-alanine residue, followed by a Lacey-Dieckman cyclisation. The 7S stereocenter was established using a rhodium based homogeneous catalyst and applying a high-pressure hydrogenation to the tetramic acid. Stable …
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Fabrication of Polymeric Microfluidic Devices for Protein Analysis
… procedures. In this work, the procedures for aminolysis and photografting of linear polyacrylamide on microchannel surfaces in PGMAMMA substrates were developed, and the performance of the resultant µCE devices was demonstrated for the separation of amino acids, peptides, and proteins. …
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The synthesis and metal ion catalysed hydrolysis of methyl 4,5-diaminopentanoate
… extremely rapid, pair of intramolecular aminolysis (lactamisation) reactions. These involve competition between five and six membered lactam ring closure. Overall constants of the order 10³ℓmol⁻¹s⁻¹ at 25°C and I = 0.10molℓ⁻¹ are observed. The Cu(II) catalysed hydrolysis of methyl …
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Synthesis and application of rhodium(I) Fischer carbene complexes
… complexes via cod ligand substitution and aminolysis reactions to isolate mono- and dicarbonylcarbene complexes 16 23, [Rh(LL)Cl{C(X)Fc}] [LL = cod, (CO)2, (CO, PPh3), (CO, PCy3), (CO, P(OPh3)), (CO, AsPh3); X = OEt,NHnPr], with variable ?-acceptor properties. Full characterization of the …
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Aspects of the mechanisms of alkaline hydrolysis of amino acid esters
… of 4-AB Me and 5-APe Me undergo intramolecular aminolysis rather than simple BAc2 hydrolysis. This is because the potential 5- and 6-membered rings are energetically the optimum size for ring closure. The resulting lactams are stable under the reaction conditions. Lactamisation also occurred for …
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SOLID-SUPPORTED PORPHYRINS FOR CATALYSIS AND SENSING
… building blocks5. PHU can be obtained by aminolysis of bis-cyclic carbonates and diamines but the synthesis of polymer with a long chain is still a challenging issue. This problem is due to the lower reactivity of cyclic carbonates with respect to their corresponding isocyanates and also …
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Design, synthesis, and characterization of porphyrin derivatives for biological applications
Chapter 1 of this Dissertation presents a brief introduction to the basic properties of porphyrins and their derivatives (hydroporphyrins), their abundance and functions in the nature, and their applications in photodynamic therapy. Chapter 2 reports the synthesis, characterization, conformational …