Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Aminoglycosides"”.
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
Aminoglycoside antibiotics remain essential for treatment of severe Gram-negative bacterial infections, yet their clinical use is limited by the risk of irreversible sensorineural hearing loss. Many signaling pathways change during ototoxic injury, but transcriptional change alone does not …
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The role of megalin in the transport of aminoglycosides across human placenta
Background: Intra-amniotic infections (IAIs) are common complications of labor and delivery. If inadequately treated, these infections can lead to significant morbidity and mortality in the mother and the fetus. Intrapartum aminoglycoside (AG) administration is recommended for the management of …
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Selection and Characterization of Strains of Staphylococcus aureus Displaying Unusual Resistance to Aminoglycosides
… of procedural variations on the activity of aminoglycosides have revealed that a single procedural change can significantly alter results, particularly in tests with Staphylococcus aureus (116,123). Variations in such factors as inoculum and type of medium used may at times also alter the …
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I. Total synthesis of sesquiterpene-tropolones II. Dearomative hydroamination and application to the synthesis of aminoglycosides
The student, Chad Ungarean, accepted the attached license on 2020-12-01 at 04:52.
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A comparison of pure tone thresholds and distortion product otoacoustic emission measures in patients with Tuberculosis receiving aminoglycosides
Includes bibliographical references (leaves 116-131).
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The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based …
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Cooperative Electrostatic Polymer-Antibiotic Nanoplexes
… the anionic polyacrylates and the cationic aminoglycosides form the cores of the nanoplexes, while the amphiphilic nature of the polyethers stabilize their dispersion in physiological media. The amphiphilic nature of the polyethers in the outer shell aid in interaction of the nanoplexes with …
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Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
… with other antimicrobials, particularly the aminoglycosides. Metbods: A retrospective cohort study of patients treated with colistin or tobramycin for A. baumannii infections in intensive care units (ICUs) at Groote Schuur hospital was performed. Colistin was used for A baumannii isolates …
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The Role of Megalin in Aminoglycoside-Associated Toxicity in the Kidney
… effective and safe antibiotic options. While aminoglycosides have been effective in treating these life-threatening MDR bacterial infections, clinical treatment with these drugs has been limited due to their high nephrotoxic potential. As a result, aminoglycosides have been conservatively used …
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Effectiveness of different medical interventions implemented when a change in hearing status is detected during ototoxicity monitoring
… Tuberculosis (TB) in South Africa (SA) in 2019. Aminoglycosides, which are commonly used anti-tuberculosis drugs in the treatment for RR/MDR-TB patients, are associated with ototoxicity (cochlear or vestibular). Aminoglycoside-induced cochleotoxicity is characterised by permanent, bilateral, …
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Development of Core-Shell Polymeric Nanostructures for Delivery of Diagnostic and Chemotherapeutic Agents
… block copolymers and cationic antibiotic aminoglycosides have been formed by electrostatic condensation. Amphiphilicity of the complexes was introduced into the shells by incorporating a hydrophobic poly(propylene oxide) segment into the block copolymer. The resulting particles have an …
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The determination of veterinary antibiotics in live animals and animal products
… of antimicrobials in foods of animal origin. The aminoglycosides and macrolides are two families of antibiotics that are very similar in structure and have important applications in veterinary medicine. These antibiotics are widely used in the treatment of bacterial infections e.g. aminoglycosides …
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Perfil de resistência aos antimicrobianos frente à pseudomonas aeruginosa isoladas de afecções oftálmicas em diversas espécies: revisão sistemática
… the lowest percentages of resistance were to aminoglycosides (amikacin, gentamicin and tobramycin), to fluoroquinolones (levofloxacin, ciprofloxacin, nofloxacin and gatifloxacin) and to Imipenem. In the isolates were observed resistance of the 82,9% to chloramphenicol, proving not to be …
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Enzyme Mediated Gentamicin Resistance Among Gram-Negative Clinical Isolates
… is on the rise (7-12). Resistance to the aminoglycosides is believed to be due to three basic mechanisms (13,14), The best characterized mechanism is the enzyme-mediated inactivation of antibiotic activity. To date eight different enzymes have been described (15). The three primary classes …
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Polyelectrolyte multilayers for tunable release of antibiotics and other therapeutics
… several types of antibiotics, ranging from aminoglycosides to antimicrobial peptides (AmPs), were fabricated and characterized; these coatings are intended for applications onto biomedical device surfaces for infection control. In vitro efficacy against Staphylococcus aureus and nontoxicity …
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Development of pattern recognition technique for classification of RNA secondary structures by small molecules
… library was obtained with commercially available aminoglycosides and through simple synthetic approaches. A training set of highly defined RNA secondary structure sequences was identified by computational modeling. I incorporated benzofuranyl uridine, a fluorescent base analogue, into the …
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IN VITRO ΑΝΑΠΤΥΞΗ ΑΝΤΟΧΗΣ ΠΡΟΤΥΠΟΥ ΣΤΕΛΕΧΟΥΣ PSEUDOMONAS AERUGINOSA ΣΤΟ ΙΜΙΡΕΝΕΜ ΚΑΙ ΙΔΙΟΤΗΤΕΣ ΑΥΤΟΥ
… CROSS-RESISTANCE TO DIBASIC PENAMS, CEPHENS AND AMINOGLYCOSIDES, BUT SENSITIVITY TO MONOBASIC PENANS, MONOBACTAMS AND POLYMYXIN-B REMAINED UNCHANGED. WE PROPOSEA "LOSS" MUTATION MECHANISM AS THE MOST POSSIBLE OVERALL MECHANISM FOR IN VITRO SELECTIVE RESISTANCE TO IMIPENEM IN P. AERUGINOSA.
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An Investigation of Bacterial Ribonucleases as an Antibiotic Target
… the bacterial ribosome. Antibiotics such as aminoglycosides and macrolides specifically target the 30S or 50S subunits to inhibit bacterial growth. During the assembly of the bacterial ribosome, ribosomal RNA of the 30S and 50S ribosomal subunits is processed by bacterial ribonucleases …
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The Distribution of Innate Antioxidant Enzymes in Rat Cochleas
… antibiotic. However, the clinical utility of aminoglycosides is limited by the potential for ototoxicity and nephrotoxicity. In the cases of aminoglycosides’ ototoxicity, the damage of outer hair cells (OHCs) progresses in a base-to-apex gradient. Although the mechanism of GM ototoxicity has …
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