Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Aminocyclohexanol"”.
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Trans-2-aminocyclohexanol as a pH-sensitive conformation switch in liposomes
… this thesis research is to develop novel trans-2-aminocyclohexanols based lipids and their liposome that can be switched by mildly acidic pH. NMR study · show that in certain acidic medium, the amine group on cyclohexane will attract proton and form hydrogen bond with the neighboring -OH. This …
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Fliposomes: pH-sensitive liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome mebrane
… pH-triggerable molecular switch, trans -2-aminocyclohexanol (TACH) has a variety of applications. By introducing two hydrocarbon tails, multiple TACH-based lipids (flipids) have been designed and studied that are able to perform a drastic conformational flip upon protonation, loosening the …
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Synthesis and conformational study of trans-2-aminocyclohexanol-based pH-triggered molecular switches and their application in gene delivery
<p>Trans-2-Aminocyclohexanol (TACH) is a promising model for pH-triggerable molecular switches with a variety of potential applications. In particular, such a switch, when incorporated into cationic liposomes, provides a novel design of the pH-sensitive helper lipids for gene delivery. Protonation …
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High-Nuclearity Lanthanide(III) Complexes as Single-Molecule Magnets and Luminescent Materials
… (saphH2), N-salicylidene-o-aminocyclohexanol (sachH2) and N-salicylidene-2-amino-5-chlorobenzoic acid (sacbH2), in lanthanide (LnIII) cluster chemistry has afforded four families of polynuclear and dinuclear complexes with new structural motifs, and interesting magnetic and …
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Design of smart linkers and their applications in controlled-release drug delivery systems
… substrates allowed the identification of 3-aminocyclohexanol scaffold as a suitable moiety for fragmentation reaction under biological mimicking conditions. The novel methodology has been applied to the controlled release of Crizotinib, a drug used for the treatment of metastatic lung …
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A Study of Conformation in Disubstituted Cyclohexanes
… disubstituted cyclohexanol systems like trans-2-aminocyclohexanol, and the methylcyclohexanol isomers, in CCl4 or CDCl3 depending on the solubility of the solutes. The chemical shift at infinite dilution has been found to give an indication of an intramolecular hydrogen bond and the chemical …
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Novel Enantiopure ß-Amino Alcohols and ß-Amino Thiols in Asymmetric Catalysis
… developed. Starting from the enantiopure trans-2-aminocyclohexanol, via relatively simple reactions it was possible to synthesize various thiols and sulfides. These compounds were then applied as ligands in the ruthenium- and iridium-catalyzed transfer hydrogenation of prochiral ketones. They were …