Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Aminoalkyl"”.
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Synthesis and Chromatographic Evolution of Structurally Rigid Naproxen Analogs and Trans-3,4-Disubstituted-2,6-Piperidinediones
… chromatographic evaluation of a number of (beta-aminoalkyl)phosphonates are reported.
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Development of Catalytic Enantioselective Minisci-type Reactions
… Minisci reaction involving N-acetyl-aminoalkyl radicals, generated by photocatalytic reduction of redox-active esters, is described. The reaction is found to be successful for a range of N-acetyl-aminoalkyl radicals on a range of quinolines and electron-deficient pyridines with high …
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Polydimethylsiloxane Modification of Segmented Thermoplastic Polyurethanes and Polyureas
… thermoplastic polyurethane with a secondary aminoalkyl functional polydimethylsiloxane (PDMS), which was intended to improve the fire resistance of polyurethane systems. The PDMS oligomer was successfully incorporated into the polyurethane backbone via one step solution polymerization. The …
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Enzymatic Sulfurylation Mechanisms
… and transfer to lipids, polysaccharides, and aminoalkyl phenols have been studied In a variety of biological systems. The transfer of S<sup>35</sup>O<sub>4</sub> from radioactive 3'-phosphoadenoslne 5'-phosphosulfate (PAPS<sup>35</sup>) into lipid-soluble material has been investigated in …
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Palladium-Catalysed Functionalisation of Csp3–H Bonds Directed by Aliphatic Amines
… ligand and a preliminary study of stoichiometric aminoalkyl palladium(II) complexes.
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Excited-state organic chemistry: Tuning photoprotective and photoredox properties
… cyclohexyl halides using four representative α-aminoalkyl radicals and the parametrization of a library of 100 boryl radicals using Density Functional Theory (DFT). Chapter 6 describes the experimental methods and procedures to develop the research work.
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Curiosities of the Electron Dynamics of Spin-Crossover Solids (Moessbauer)
… ligands derived from salicylalaldehyde and N-(aminoalkyl)aziridines have been prepared and their spin-crossover properties in the solid state have been characterized using variable-temperature (4.2-313 K) magnetic susceptibility, EPR spectroscopy, and ('57)Fe Mossbauer spectroscopy. For the …
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The synthesis and fluorescence properties of some substiuted naphthalimides
… photophysical behaviour of a series of 4-amino-9-aminoalkyl-1,8-naphthalimides in water were studied as a function of pH. Changes in the absorption and fluorescence properties of the compounds due to the protonation of the 4-amino group were observed and used for calculation of the pKa5 and …
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New Strategies and Transformations for the alpha-Functionalization of Amines to Access Chiral Amines
… hydride into 2-azadienes, we could access alpha-aminoalkyl metal species, which could be further used in reactions with various electrophiles. Two applications were examined in this chapter: 1) addition to ketones to access 1,2-amino tertiary alcohols and 2) addition to aldimines/ketimines to …
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Palladium-mediated C–H Functionalization of Aliphatic Amines via High Valent Palladium(IV) Intermediates
… acid groups provided access to isolable aminoalkyl Pd(IV) complexes that were stable at room temperature, allowing for the study of the structure and reactivity of these previously elusive high valent intermediates. In addition to C(sp3)–H functionalization of all-alkyl amines, C(sp2)–H …
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Enhancing the cooperative binding properties of1,1'-bis(1,2,3,4-tetrahydroisoquinolines)
… cooperativity. The introduction of ω-aminoalkyl, ω-azidoalkyl, ω-alkynyl and ω-alkenyl groups onto the nitrogens of the reduced bisisoquinoline core was conducted with the intention of broadening the scope of the ligand. Subsequent epoxidation, hydroboration and Huisgen 1,3-dipolar …
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Protein mis-folding and human disease
… has been co-crystallized with three different aminoalkyl<br/>phosphonates that bind at the amyloid recognition site of SAP, and the X-ray<br/>crystal structures were determined at atomic resolution.<br/><br/>A secondary aim of this work was to understand the enhanced amyloidogenic<br/>potential …
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Iridium-catalyzed borylation of aromatic and aliphatic C-H bonds: methodology and mechanism
… of a reaction intermediate. The preparation of aminoalkyl and alkoxyalkylboronate esters is described in Chapter 5. The products of these reactions directly undergo Suzuki-Miyaura cross-coupling reactions. Alternatively, the products can be isolated as air stable potassium trifluoroborate salts. …
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Boosting Biodetection Signals via Photopolymerization: Strategies for Photocatalyst Amplification
… that oxygen is consumed stoichiometrically by α-aminoalkyl radical of triethanolamine (TEOA) and reduced eosin Y radical produced during the eosin Y/TEOA photocatalysis. We also identified eosin Y degradation pathways from the reduced eosin Y radical at low oxygen levels. These degradation …
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The Chemical Synthesis of Model Catalysts Related to Enzymes
… "lysohistidine derivative" is a complicated 2-α-aminoalkyl-histidine and the classical imidazole syntheses routinely used to make 2,4-dialkylimidazoles failed when applied to this problem. The "lysohistidine derivative" with the various reactive groups protected was successfully prepared only …
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Design and synthesis of novel non peptidomimtic beta-secretase inhibitors in the treatment of Alzheimer's disease
… were elaborated to the target structures 3-(α-aminoalkyl)-1-cyclohexane carboxylic acids in a new readily accessible way.
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Study of the reaction of nitriles with dialkyl phosphites for synthesis of a-Amino-bis-phosphonates
<p>Amino bisphosphonate compounds are found in a vast array of products from water chelators to flame retardants to pharmaceuticals. Previous methods to synthesize these compounds involved the use of protic acids, which don’t provide ideal conditions for the starting materials containing acid …