Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Amino-polyesters"”.
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Design and synthesis of ionisable amino-polyester lipid nanoparticles for extrahepatic RNA delivery
… can help overcome these limitations. Ionisable amino polyesters (APEs) synthesised via ROP and co-formulated with lipids into nanoparticles (APE-LNPs) have demonstrated selective mRNA delivery to non-liver tissues. In the first part of this work, 36 ionisable APEs were synthesised to investigate …
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Tie-ing the endothelium: development of an mRNA-based nanotherapeutic to restore microvascular barrier function for the treatment of sepsis-induced multiple organ failure
… lipids, such as ionizable polymers [e.g. amino-polyesters (APE)], is therefore paramount to help expand the therapeutic utility of mRNA in acute inflammatory diseases such as sepsis. In this thesis, I explored the therapeutic potential of upregulating Tie2 in endothelial cells via …