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Showing 1 to 6 of 6 for “"Amino acids--Synthesis"”.
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1-Acylamido boronic acids and Difluoroborane analogs of amino acids: Synthesis and biological activity of transition state analogs for Chymotrypsin and Elastase (inhibition, esters)
"Several acylamido boronic acids and difluoroborane analogs of amino acids, some as single enantiomers, have been synthesized and evaluated as ""transition state"" inhibitors of the serine proteases (alpha)-chymotrypsin and elastase. These inhibitors were designed to resemble N-acyl phenylalanine, …
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The asymmetric synthesis of amino acids via electrophilic glycinates
A new asymmetric synthesis of α-monosubstituted-α-amino acids using D- and L-erythro-4-benzy loxycarbonyl-5,6-diphenyl-2,3,5,6-tetrahydro-1,4-oxazin-2-ones 108 as amino acid templates is described. Bromination of 108 with NBS generates the key electrophilic glycinate 132 which couples with a …
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The asymmetric synthesis of (2S,3R)-capreomycidine and the total synthesis of capreomycin IB
An efficient and asymmetric synthesis of the non-proteinogenic amino acid (2S,3R)-capreomycidine is presented. The synthesis features a novel aluminum enolate-aldimine reaction with a chiral glycinate, which sets both stereocenters. A concise and high-yielding approach to the unnatural amino acid …
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Synthesis of novel quaternary alpha-amino acids and 2-imidazolines derived from oxazol-5(4H)-ones and evaluation of their proteasoman inhibition activity
Thesis (Ph. D.)--Michigan State University. Dept. of Chemistry, 2010
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A computational study of Trishomocubane amino acid dipeptide
A dissertation submitted in partial fulfilment of the requirements for the degree of Master of Technology: Chemistry, Durban Institute of Technology, Durban, South Africa, 2004.
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AB initio studies of a pentacyclo-undecane cage lactam
Submitted in fulfilment of the requirements for the Degree of Master of Technology: Chemistry, Durban Institute of Technology, Durban, South Africa, 2003.