Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Amino acid transporter"”.
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Novel Amino Acid Transporter-Targeted Radiotracers For Breast Cancer Imaging
… brain tissues. Therefore, <sup>18</sup>F-labeled amino acid-based radiotracers have been reported as an alternative, which is based on the fact that tumor cells uptake and consume more amino acids to sustain their uncontrolled growth. Among those radiotracers, <sup>18</sup>F-labeled tyrosine and …
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Characterization of the amino acid transporter AAP1 in Arabidopsis thaliana
Amino acids are essential molecules in plant metabolism. Amino acids carry reduced nitrogen while serving as precursors for protein synthesis and secondary metabolites. Translocation of amino acids in the cell is mediated by amino acid transporters. While about 100 transporters have been …
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Mass Spectrometric Characterization and Fluorophore-Assisted Light Inactivation of Human Excitatory Amino Acid Transporter
Glia-expressing excitatory amino acid transporter 2 (EAAT2) mediates the bulk of glutamate re-uptake in the human central nervous system (CNS) and is associated with a variety of neurological disorders. Our understanding of the structure and mechanism of this integral membrane protein is limited. …
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Mass Spectrometric Characterization and Fluorophore-Assisted Light Inactivation of Human Excitatory Amino Acid Transporter
Glia-expressing excitatory amino acid transporter 2 (EAAT2) mediates the bulk of glutamate re-uptake in the human central nervous system (CNS) and is associated with a variety of neurological disorders. Our understanding of the structure and mechanism of this integral membrane protein is limited. …
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Regulatory Balance Between the Peptide Trasporter, Pept1, and Amino Acid Transporter Gene Expression in the Enterocyte
Amino acids are assimilated by membrane-associated transporters into and out of enterocytes either in their free form or in the form of peptides. The peptide transporter, PepT1, is thought to be the major facilitator of peptide transport in the enterocyte. It is unknown if the peptide transporters …
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
<p>This work describes the synthesis and initial characterization of the biological activity of a family of EAAT3 preferring inhibitors, L-β-benzyl aspartate (L-β-BA) and L-β-BA derivatives. L-β-BA and derivatives were initially synthesized in an approximate 2:1 ratio of …
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
<p>This work describes the synthesis and initial characterization of the biological activity of a family of EAAT3 preferring inhibitors, L-β-benzyl aspartate (L-β-BA) and L-β-BA derivatives. L-β-BA and derivatives were initially synthesized in an approximate 2:1 ratio of …
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Members of the Preprotein and Amino Acid Transporter Family Constitute Components of Novel Protein Import Pathways into Chloroplasts
… of the PRAT family comprising preprotein and amino acid transporters found in chloroplasts, mitochondria and free-living bacteria. Different expression patterns and localization of PRAT proteins suggest that they are functionally diverse beyond their role in protein translocation. QTC24/HP20 …
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NAT2/AAP1 as a Prototypical Example of the AAP Amino Acid Transporter Gene Family: From Protein Topology to Regulation of Gene Expression
… evidence connecting nitrate assimilation and amino acid transport. This observation supports the notion that NAT2 may be involved in phloem loading of newly synthesized amino acids in leaves. In addition, carbohydrate is able to enhance NAT2 expression in dark-adapted plants, suggesting the …
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Molecular and Genomic Analysis of Nitrogen Regulation of Amino Acid Permease I (Aap1) in Arabidopsis
… are key steps in regulating expression of amino acid transporter AAP1, this may lead to modulated phloem loading of amino acids and finally influence plant nitrogen status.
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Towards the development of an RT-PCR protocol for malaria parasite genes
… the identification and characterisation of an amino acid transporter gene of the human malaria parasite, Plasmodium falciparum, as a possible therapeutic target. Since no sequence information was available, 3 '-RACE (a modified form of RT-PCR) was chosen as a method to obtain the gene sequence. …
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Amino Acid Transporters in Arabidopsis Thaliana
Two novel amino acid transporters, LHT1 and ART1, were identified from the Arabidopsis EST cDNA library by complementation. LHT1 is a lysine and histidine transporter, and ART1 is an arginine and aromatic amino acid transporter. ART1 seemed to possess transport activity for IAA and other aromatic …
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
… mediate the entry of drugs into the cell. Some amino acid transporters fulfil the criteria needed for successful exploitation of nutrient transport systems for drug delivery. The Trypanosoma brucei genomic database was screened to identify the full gene repertoire of amino acid transporters. …
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THE EFFECTS OF ORAL ARGININE ON ITS METABOLIC PATHWAYS IN SPRAGUE-DAWLEY RATS
… measured the expression of the primary arginine transporter, cationic amino acid transporter 1. Oral L-arginine did not alter the expression of cationic amino acid transporter 1 or the levels of arginine and lysine, which use the same transporter, in the plasma and various organs. Oral L-arginine …
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Differential BCAA Metabolism in Tissues of Tumor-Bearing Mice: A Path to Understanding Cancer Cachexia
… to nutritional support. While branched-chain amino acids (BCAAs) stimulate muscle protein synthesis, BCAA-targeted therapies have shown inconsistent results. In this study, a C26 colon cancer mouse model was used to examine how tumor burden alters BCAA metabolism across skeletal muscle, liver, …
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Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… nNOS/NO signaling regulation of excitatory amino acid transporter 4 (EAAT4) on PN dendrites and glutamic acid decarboxylase (GAD) expression/function between sexes by using wildtype (WT) and nNOS-/- mice at different postnatal developmental time points. This study revealed that there are …
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Studies of amino acid sensing by the mTORC 1 pathway
… have only begun to unravel in recent years how amino acids signal to mTORC 1, thanks in large part to the identification of the Rag GTPases, which recruit mTORC 1 to the lysosomal surface for catalytic activation, and of the regulators of Rag function. An ultimate goal is to uncover the …
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Profiling L-serine Transport Throughout Growth and Meiotic Maturation in Mouse Oocytes
… certain nutrients. This thesis focuses on the amino acid serine, which has been shown to improve outcome in developing embryos and also plays a variety of roles in the body that may carry over to oocyte health as well. Using radiolabeled [3H] serine, we measured uptake of serine as a function …
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Identifying Merozoite Targets of Protective Immunity Against <i>Plasmodium falciparum</i> Malaria
… did not. These antigens were the pantothenate transporter (PfPAT), a putative amino acid transporter (PF3D7_0629500), PF3D7_0830500, PF3D7_1025300, PF3D7_1345100 and PF3D7_1401600. In addition, the breadth of antibody responses to the tested antigens was associated with protection from clinical …
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