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Showing 1 to 20 of 77 for “"Amino Acids, Peptides, and Proteins"”.
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Velocity-difference induced focusing in capillary electrophoresis and preparative capillary electrophoresis
… an appropriate dye to monitor the pH of the BGE and the sample during the focusing process. A mechanism was proposed based on the experimental results. This technique was then applied to serotonin to improve the detection limit when CE was used with a UV absorption detector. It was also applied …
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Fabrication of Polymeric Microfluidic Devices for Protein Analysis
… substantially reduced electroosmotic flow and nonspecific adsorption of proteins. Both column efficiency and migration time reproducibility were one order of magnitude better with derivatized PMMA µCE devices compared to untreated versions. Fast, reproducible, and efficient separations of …
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Some Supplementary Studies with Wheat Proteins
… importance of selecting only foods containing proteins of high nutritive value has been somewhat over-emphasized in the past because of the failure to recognize the possibility of supplementary relationships among proteins that are not of high quality. Hart (11) has wisely suggested that a food …
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Development of Novel Peptide-Doxorubicin Conjugates for Targeting Triple-Negative Breast Cancer
… breast cancer (TNBC) is the most aggressive and difficult to treat subtype of breast cancer. Chemotherapy is an active treatment option in combination with other treatments; however, the side effects limit the effective therapeutic dose. To selectively target the cancer cells, I have …
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Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
<p>Here, we synthesized a novel group of linear and cyclic amphiphilic peptides containing different sequences of arginine (R) and tryptophan (W) residues. The peptides included a class of cyclic peptides, [R3W3]2, [R3WRW]2, [RWW]4, [WRR]4, [RWRW3]2, and the corresponding linear peptides, (R3WRW)2, …
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Characterisation of the cross-linking and calcification associated with glutaraldehyde-treated cardic bioprostheses.
… bioprosthetic devices enhances patient survival and quality of life. Bioprosthetic valves have a significant advantage over mechanical valves: they do not necessarily require long-term anticoagulant therapy however, dystrophic calcification can lead to early failure. The actual mechanism of …
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Submonomer Synthesis and Structure-activity Relationship Studies of Azapeptide Inhibitors of the Insulin Receptor Tyrosine Kinase
<p>Azapeptides are a class of peptide mimics (peptidomimetics), which have served as valuable tools for the development of peptide based therapeutic agents. The therapeutic promise of azapeptides has been correlated to its primary sequence modification which translates into bio-active secondary …
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A Study of the Effect of Varying Serum Phenylalanine Levels on Changes in Intelligence Quotient
… 6 through 11 months, 12 through 23 months, and over 2 years of age.</p> <p>Among 6 patients who were placed on the diet during the first 5 months of life, it appears that the optimal serum phenylalanine level to maintain I.Q. was between 0-3.9 mg.%. The average I.Q. at the beginning of …
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Cytotoxic Activity of Non-Specific Lipid Transfer Protein (nsLTP1) and Proteomic Evaluation of Heparin-Binding Proteins from Ajwain (Trachyspermum ammi) Seeds
… activity of ajwain nsLTP1 in MCF-7, AsPC-1, and MCF10A cell lines and its structural stability in human serum and high-temperature conditions. The antiproliferative activity of ajwain nsLTP1 was evaluated in MCF-7 and AsPC-1 cell lines using an MTT assay. Annexin V-FITC and PI staining were …
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High Pressure Liquid Chromatography Studies of the Reaction of Platinum Complexes with Peptides
Platinum complexes (cisplatin, carboplatin and oxaliplatin) are effective anticancer agents. However the major drawbacks of platinum chemotherapy are toxic side effects and resistance. The affinity of platinum complexes to sulfur donor ligands of side chains of methionine and cysteine amino acids …
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The N-terminal Domain of the Y-box Binding Protein YB-1 Plays a Major Role in Cell Proliferation and Apoptosis
… a member of the cold shock domain superfamily of proteins. It is involved in a plethora of cellular functions, including cell proliferation. The molecular mechanisms governing the involvement of YB-1 in cell proliferation are still unclear. Earlier studies done in chicken pre-B lymphocyte DT-40 …
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A Pretargeted Spect Imaging Strategy Employing Technetium-99M Based on Bioorthogonal Diels-Alder Click Chemistry
… complexes were synthesized and tested for use in pretargeting SPECT imaging that utilizes the bioorthogonal Diels-Alder click reaction between tetrazine (Tz) and transcyclooctene (TCO). The objective was to optimize the excretory pathways of the <sup>99m</sup>Tc-peptide …
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Phage Display Library Screening For Psa-/Lo Prostate Cancer Cell-Binding Peptides
… men worldwide. Our lab focuses on understanding the molecular mechanisms underlying prostate carcinogenesis and developing therapeutics that target the cells responsible for driving PCa and mediating therapy resistance. My master thesis research employs a phage display library screening …
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Protein-Protein Interactions and Muscle cell Signaling Via Syntrophin
… dystrophin is associated with a complex of proteins and glycoproteins, known as the dystrophin glycoprotein complex. The DGC constituents are dystrophin, a-dys troglycan, b-dystroglycan, syntrophin, a-sarcoglycan, b-sarcoglycan, g-sarcoglycan, d-sarcoglycan, and sarcospan. Not al l of these …
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Fasting Plasma Amino Acids in Relation to Serum Lipids in Human Male Subjects
<p>The association of fasting plasma amino acids with serum lipids was studied in 23 healthy human male subjects with ages ranging from 31 to 62 years (45±9, mean± SD). There were 12 normocholesterolemic (serum cholesterol = 183±17 mg/dL) and 11 hypercholesterolemic (271±27 mg/dL) subjects. Venous …
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Localization of Calbindin-D<sub>28k</sub> in Extra-Embryonic Membranes of Two Oviparous Scincid Lizards.
… transport calcium. The chorioallantoic membrane and yolk sac of oviparous squamate reptiles (lizards and snakes) transport calcium from the eggshell and yolk to the developing embryo. I used immunohistochemistry to localize calbindin-D<sub>28K</sub> expression in the chorioallantoic membrane and …
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Mapping The Human Vasculature By In Vivo Phage Display
… screenings by intravenous injection of a random phage-displayed peptide library allow for the selection of peptides that localize to specific vascular beds. At the University of Texas MD Anderson Cancer Center, we have had the opportunity to perform phage display screenings in cancer …
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Molecular Mechanisms of Interleukin-1beta-Stimulated Regulation of Angiogenesis in Cardiac Microvascular Endothelial Cells.
… for supplying a healing myocardium with oxygen and nutrients to sustain metabolism post myocardial infarction (MI). Interleukin-1β (IL-1β), a proinflammatory cytokine increased in the heart post-MI, is considered essential for angiogenesis in tumor growth and metastasis, arthritis, …
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Synthesis, characterization and applications of peptide-coated nanoparticles
… mainly due to its high recurrence rate and poor diagnosis. Most patients present with late stage of the disease, and less than 25% of patients survive the five years mark. Nanotherapy provides significant and unique benefits for drug efficacy, as nanoparticles (NPs) can increase the …
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