Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Amine oxidase"”.
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Production of novel amine oxidases from microorganisms
… over-expression of an industrially important monoamine oxidase was attempted using different expression systems, both homologous and heterologous, and the optimum conditions for the industrial production were established. Amine oxidases exhibit stereoselectivity, and, therefore, can potentially be …
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Flavin Amine Oxidases from the Monoamine Oxidase Structural Family Utilize a Hydride Transfer Mechanism
The amine oxidase family of enzymes has been the center of numerous mechanistic studies because of the medical relevance of the reactions they catalyze. This study describes transient and steady-state kinetic analyses of two flavin amine oxidases, mouse polyamine oxidase (PAO) and human lysine …
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Studies into novel therapies for the treatment of inflammatory artery disease
… pro-inflammatory and pro-oxidant enzyme myeloperoxidase (MPO) in inflammatory artery disease was studied. A clinical study showed that while circulating plasma MPO levels were not different in AAA patients versus healthy controls, immunohistochemistry showed that the MPO protein was prevalent in …
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Gas migration inside proteins: Mechanism, characterization, and applications
… of proteins such as globins, oxygenases, and oxidases, which store oxygen gas or use it for enzymatic purposes. One reason why this process has not received prominent attention in recent years was because of difficulties in identifying the pathways taken by oxygen or other gases diffusing …
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Development and characterization of anti-EGFR protein-drug conjugates for tumor therapy
… of the head and neck and gliomas. This thesis examined the development of bivalent anti-EGFR protein-drug conjugates, analyzed _in vitro_ and _in vivo_, and provided insights into novel concepts of enzyme-based bioconjugation strategies. <br />All FDA-approved ADCs are currently produced by …