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Showing 1 to 20 of 38 for “"Amiloride"”.
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Characteristics of sodium transport through the amiloride-sensitive sodium-magnesium pathway in hamster red cells
In hamster red cells, amiloride-sensitive Na influx, 0.8 mmol/l cell/hr, is the only, carrier-mediated, Mg-dependent pathway for inward Na transport. This Na-dependent Mg transport is involved in the regulation of intracellular Mg$\sp{2+}$ concentration under physiological conditions.
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Effects of Doca(+ Deoxycorticosterone Acetate) and Amiloride on Sodium and Potassium Transport by the Isolated Cortical Collecting Tubule of Rabbit
Made available in DSpace on 2014-12-14T13:39:38Z (GMT). No. of bitstreams: 1 7624155.pdf: 3902358 bytes, checksum: 62b6ca409fbfaeb2e8c5ddef810c0744 (MD5) Previous issue date: 1976
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Amiloride-sensitive components of sodium transport in guinea pig red blood cells: A cause of imbalance of sodium ion at low temperature
… during cold storage at 5$\sp\circ$C in vitro and amiloride can partially inhibit the accumulation. Also, amiloride-sensitive Na influx in guinea pig red cells is known to be larger at 20$\sp\circ$C than at 37$\sp\circ$C.
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Elucidation of the epithelial sodium channel as a salt taste receptor candidate and search for novel salt taste receptor candidates
… mechanisms. One is sensitive to the drug amiloride and specific for Na+, involving epithelial sodium channel (ENaC). A second rodent transduction pathway, which is triggered by various cations, is amiloride insensitive and not almost understood to date. Studies in primates showed …
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The role of Serum- and Glucocorticoid kinase in the hormonal control of sodium transport in pulmonary epithelia
… do not display ENaC activity as there is no amiloride sensitive current in these cells. Groups of dexamethasone-treated H441 cells do display ENaC activity; however single cells do not display ENaC activity despite displaying an increase in current. Thus cell-cell contact is vital to the …
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Mechanism of Inhibition of Transepithelial Sodium Transport in Frog Skin by Quinine and Quinidine (Noise Analysis, Cgs 4270, Basolateral Membrane)
… were obtained with epithelia treated with amiloride. Consistent with these results quinine and quinidine caused a marked inhibition of unidirectional ('42)K flux across the basolateral membrane and hence caused a large decrease of P(,K). In the absence of any demonstrable conductance to …
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Analysis of ASCL1 in Neuroendocrine Lung Cancer
… gene ENaC can be pharmacologically inhibited by amiloride, a drug that has been used clinically for nearly 50 years. Amiloride-treated ASCL1-dependent tumor cells stopped cell growth in vitro. Analysis of downstream targets of ASCL1 broadens our understanding how ASCL1 functions, and further …
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Magnesium Transport In Mammalian Erythrocytes And Its Effect On Platelet Aggregation
… failure is associated with large fluxes of Mg 2+ Amiloride (a sodium channel blocker) and N-methyl-D-glucamine (NMDG) a substitute for sodium were used to test the mechanism of Mg 2+ transport. Following Mg 2+ loading, in pre-dialysis patients the Mg 2+ efflux in the presence of (10 -3 M) …
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Mechanism of Aldosterone Regulation of Sodium Transport in A6 Epithelia
… stimulation of Na$\sp+$ transport through amiloride-sensitive Na' channels (ENaCs) in cell cultured A6 epithelia. Non-invasive methods of blocker-induced noise analysis were used to investigate the way aldosterone changes the single channel current $(i\sb{Na}),$ open probability $(P\sb{o})$ …
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Dilution acidosis : the effects of hyperosmolality on acid-base balance and ventilation
… blocker DIDS and the Na+/H+ exchange blocker amiloride reversed the intracellular pH change from alkalosis to acidosis, although they did not affect the extracellular acidosis caused by acute hyperosmolality. These results indicated that hyperosmolality altered both Cl/HCO3- andNa+/H+ exchange …
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Nerve growth factor regulates Na+ transport in human airway epithelial cells
… to the apical membrane decreased Isc by 5.3 %. Amiloride (apical, 3.5x10-5 M), which inhibits Na+ transport, decreased Isc by 55.3 % in the absence of NGF, but this response was reduced (41.6 %; p = 0.0127) in the presence of 1 ng/ml NGF, which indicated NGF was affecting amiloride-sensitive Na …
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Distal tubule bicarbonate reabsorption.
… substitution augmented by pharmacologic means (amiloride); (4) inhibition of carbonic anhydrase by acetazolamide. At 8 nl/min, collection of fluid from tubules perfused with all 4 solutions revealed significant bicarbonate reabsorption. Net distal tubule bicarbonate reabsorption was …
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Comparison of the sodium ion channel densities, the water flux changes, and the membrane capacitance changes in the pelvic and pectoral skin of the toad, Bufo woodhousei
… current (I{dollar}\sb{\rm sc}{dollar}) and the amiloride sensitive current (I{dollar}\sb{\rm Na\sp+}{dollar}) both increased significantly in the pelvic and in the pectoral skin after AVT treatment, but to a larger degree in the pelvic skin. If M is expressed as a function of C{dollar}\sb{\rm …
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The development of novel strategies to modulate epithelial sodium channel (ENaC) activity in chronic obstructive pulmonary disease (COPD)
… prostasin. QUB-2136 was capable of inhibiting amiloride short-circuit current to a greater extent and for a longer period of time when compared to QUB-1916. However, further evaluation of QUB-2136 indicated that structural modifications would be necessary in order for this peptide to have …
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Investigations into mechanisms of magnesium homeostasis in the isolated rat heart
… was significantly inhibited by 10" M and 10 M amiloride, but not by 10 M ouabain. Propranolol (10" M) and 10 7 M verapamil inhibited Mg2t efflux under control conditions. Niflumic acid (10' M) produced a small but delayed response in Mg2t efflux, under both control conditions and in response to …
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The effect of night time diuretic chronotherapy on quality and duration of sleep among Zambian hypertensive patients
… and the majority were on hydrochlorothiazide and amiloride combination (72.0%). The 10PM dosing showed significant differences in quality of sleep with p-value of 0.010 at 12 weeks follow-up. The duration of sleep did not show significant differences between the groups with p-value of 0.215. The …
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The effect of night time diuretic chronotherapy on quality and duration of sleep among Zambian hypertensive patients
… and the majority were on hydrochlorothiazide and amiloride combination (72.0%). The 10PM dosing showed significant differences in quality of sleep with p-value of 0.010 at 12 weeks follow-up. The duration of sleep did not show significant differences between the groups with p-value of 0.215. The …
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The effect of night time diuretic chronotherapy on quality and duration of sleep among Zambian hypertensive patients
… and the majority were on hydrochlorothiazide and amiloride combination (72.0%). The 10PM dosing showed significant differences in quality of sleep with p-value of 0.010 at 12 weeks follow-up. The duration of sleep did not show significant differences between the groups with p-value of 0.215. The …
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