Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Amikacin"”.
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Elution of Antibiotics from a Novel Cross-linked Dextran Gel: In vivo Quantification
Amikacin-, vancomycin- or amikacin/clindamycin-impregnated gel was placed subcutaneously on either side of horses' necks a total of 6 times each. Interstitial fluid was collected at 0, 4, 8, 12 and 24 hours, and days 2 through 10, via capillary ultrafiltration probes placed within the incision …
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The Role of Megalin in Aminoglycoside-Associated Toxicity in the Kidney
… nephrotoxicity. Subsequent studies show that amikacin accumulates in the kidney during the filtration process and triggers a cascade of cellular events resulting in cell death, acute kidney injury and in some cases, chronic kidney failure. Additional studies show that amikacin primarily …
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Investigating the Molecular Mechanism of Ribosome Recycling
… function, including recycling inhibition. Amikacin, the semisynthetic derivative of kanamycin, is commonly used for treating severe infections with multidrug-resistant, aerobic Gram-negative bacteria. Amikacin carries the 4-amino-2-hydroxy butyrate (AHB) moiety at the N1 amino group of the …
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Factors that enhance the ability of Pseudomonas aeruginosa to resist the action of antibiotics
… was subjected to the action of tobramycin, amikacin and colistin under various environmental factors. The results of the in vitro analysis showed that, from among the three antibiotics used, amikacin was the antibiotic where resistance was most readily developed. From these results, …
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Development of Drug Loaded Nanoparticles for Treatment of Mycobacterium avium Infection
… in vitro efficacy studies were done with a) amikacin-loaded nanoparticles, b) clarithromycin-loaded nanoparticles, and c) with aerogel nanoparticles loaded with rifampicin, clarithromycin and ethambutol. Clarithromycin (CLA) and amikacin (AMK) loaded nanoparticles showed a significant …
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Biochemical and antibiogram characteristics of certain enterobacteriaceae
… Escherichia coli. New antibiotics (tobramycin, amikacin and cefamandole) are also added to the antibiogram.
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Investigation of diarrhoea in critically ill patients receiving enteral nutrition
… sucralfate and antibiotic therapy other than amikacin. Twenty one patients received Ensure and 27 received Casilan Oil. Despite the differences in the composition of the feeds, the incidence of diarrhoea was similar on the Ensure and the Casilan Oil. No particular factor pertaining to the …
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Colonisation with extended spectrum beta-lactamase producing and carbapenem-resistant enterobacterales in children admitted to a paediatric referral hospital in South Africa
… to piperacillin/tazobactam (86.2%) and amikacin (63.9%). Similarly, 94.4% and 97.2% of the Escherichia coli isolates were susceptible to piperacillin/tazobactam and amikacin, respectively. Hospitalisation for more than 7 days before study enrolment was associated with ESBL-PE …
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Baseline prevalence and incidence and risk factors for new-onset drug induced hearing loss in adults receiving drug-resistant tuberculosis (DR-TB) treatment in Khayelitsha, South Africa
… Second line injectable therapy using kanamycin, amikacin or capreomycin is associated with irreversible hearing loss. There is a scarcity of literature regarding the frequency of hearing loss as well as associated risk factors, particularly with long term use. This study aimed to determine the …
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Ventilator Associated Pneumonia (VAP): a retrospective review of all children diagnosed with a VAP during 2017 and 2018, in the PICU, Red Cross War Memorial Children's Hospital.
… was an ESBL Klebsiella pneumoniae sensitive to Amikacin and carbapenems. Conclusion: Our VAP rate has not decreased further since 2013. The VAP rate was slightly higher in 2018, and it is imperative that we improve compliance with the VAP bundle, in order to reduce VAP rates. Klebsiella …
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In vitro evaluation of equine bone-marrow derived mesenchymal stromal cells to combat orthopedic biofilm infections
… We investigated whether MSC alone or with amikacin sulfate, an antibiotic used to treat equine orthopedic infections, could reduce biomass, pellicle size, and live bacteria of biofilms of orthopedic infectious agents S. aureus and E. coli. Next, we investigated whether MSC could modulate …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΗΣ ΑΝΤΟΧΗΣ ΤΩΝ ΨΕΥΔΟΜΟΝΑΔΩΝ ΣΤΑ ΑΝΤΙΒΙΟΤΙΚΑ
… WERE FROM THE AMINOGLYCOSIDE GROUP (GENTAMICIN, AMIKACIN, NETILMICIN), THE 3RD GENERATION CEPHALOSPORINS GROUP (MOXALACTAM, CEFOTAXIME, CEFTAZIDIME, CEFSULODINS AND FROM THE BROAD SPECTRUM PENICILLINS GROUP (CARBENICILLIN).THE DETERMINATION AND CHARACTERIZATION OF B- LACTAMASES, PRODUCED BY 14 …
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Perfil de resistência aos antimicrobianos frente à pseudomonas aeruginosa isoladas de afecções oftálmicas em diversas espécies: revisão sistemática
… of resistance were to aminoglycosides (amikacin, gentamicin and tobramycin), to fluoroquinolones (levofloxacin, ciprofloxacin, nofloxacin and gatifloxacin) and to Imipenem. In the isolates were observed resistance of the 82,9% to chloramphenicol, proving not to be effective against …
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Investigation of the Genetic Basis of Antibiotic Resistance in Mycobacterium tuberculosis
… of resistance to ofloxacin and kanamycin/amikacin in M. tuberculosis were designed, and their ability to correctly identify resistance to these second-line drugs was evaluated. Multiplex allele-specific-PCR assays for the detection of GyrA D94G and rrs A1401G correctly identified ofloxacin …
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Επίδραση της χρήσης αντιβιοτικών στις μέσες και υψηλές ακοομετρικές συχνότητες
… οποίοι έλαβαν για τουλάχιστον 4 συνεχείς ημέρες amikacin (4 άτομα), gentamycin (47 άτομα) και tobramycin (2 άτομα) και οι οποίοι δεν είχαν κανένα προηγούμενο πρόβλημα που να αφορά το όργανο της ακοής. Για τη μελέτη αυτή κρίθηκε απαραίτητη προϋπόθεση ένα ελάχιστο 4 ακουογραμμάτων. Από τις πρώτες …
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Three-Dimensional (3D) pharmacophore-based identification of possible ATP-synthase inhibitors for mycobacterium tuberculosis (Mtb)
… second- line drugs (Capreomycin, Kanamycin and Amikacin). Bedaquiline (BDQ) is a diarylquinoline aimed at inhibiting the adenosine triphosphate (ATP) synthase of MDR-TB, thereby targeting the energy metabolism mechanism of Mtb. Drug regimens utilized prior to BDQ have shown low success rates in …
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A study of clinical strains of Pseudomonas Aeruginosa and the investigation of antibiotic resistance mechanisms in the multidrug resistant strain PA13
… cefepime, ceftriaxone, meropenem, aztreonam, amikacin, apramycin, butirosin A, lividomycin and colistin sulphate. One of the isolates, PA13, was resistant to a further fourteen antibiotics and was identified as a multidrug resistant strain. A 2.2 kbp PCR product was amplified from P. …
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Developing an antibiogram for empiric antibiotic prescribing for orthopaedic infections in adult patients at a South African tertiary orthopaedic unit
… would have been either piperacillin-tazobactam, amikacin and vancomycin or meropenem and vancomycin; 90% of tested isolates were susceptible to either of these combinations. Conclusion Antibiogram profiles can serve to guide to empirical antibiotic choice in the management of different categories …
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A multiplexed microfluidic platform for antibiotic susceptibility testing
… individual susceptibility to antibiotics such as amikacin and tobramycin increases in co-cultures. I illustrate the advantages of using microfluidics over conventional methods for AST for precise determination of antibiotic dosing regimen, which encompass a significant potential to address the …
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Prevalence of Multidrug-Resistant Tuberculosis in Adults at University Teaching Hospital
… line injectable drug(capreomycin, kanamycin or amikacin) and a fluoroquinolone. China, India and the Russian Federation are thought to carry the largest MDR-TB global caseload. World Health Organization (WHO) estimates that there were 66,700 MDR-TB cases in Africa in 2006. In 2005 approximately …
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