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Showing 1 to 20 of 34 for “"Amidine"”.
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Transfer of alkyl groups in novel amidine dications and other superelectrophiles
… the synthesis and the reactivity of novel amidine salts resulting from various N-methylformamides and N-methylbenzamides I and II. Treatment of these compounds with triflic anhydride under mild conditions led to extremely facile alkyl transfer from an sp3-hybridised nitrogen centre to very …
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NOVEL ETHYLENE-BRIDGED HEXADENTATE BIS(AMIDINES), BIS(AMIDINATES), AND MULTINUCLEAR COINAGE METAL BIS(AMIDINE) COMPLEXES
<p>A new series of hexadentate flexible bis(amidine) ligands (<strong>L<sup>1–6</sup></strong>H<sub>2</sub>) and the multinuclear coinage metal complexes <strong>1</strong>–<strong>5</strong> of <strong>L<sup>4</sup></strong>H<sub>2</sub> were synthesized and characterized. The synthesis of<strong> …
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Early transition metal complexes of carbene donors linked to cyclopentadienyl ring analogues or amidine/amidinate moieties
… of amidinate-functionalised NHC zirconium and amidine-functionalised<br/>NHC silver complexes. Double deprotonation of 3-(2,6-diisopropylphenyl)-1-[N, N’-bis(2,6-<br/>diisopropylphenyl)acetamidyl] imidazolium chloride gave the amidinate-functionalised NHC<br/>ligand, …
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Kinetic Resolution of N-Acyl-b-Lactams, b-Lactams, and N-Acyl-Thiolactams using Amidine-Based Catalysts
… group has developed 4 consecutive generations of amidine-based catalysts: ABCs) that have engaged in a variety of enantioselective acylation transformations, mostly Type I: KR of various alcohols and lactams: and thiolactams) via asymmetric acylation) and Type III: enantioselective alcoholysis of …
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Bis-and tris (amidine) fluoroboron cations and related systems studies by Multinuclear NMR and fast atom bombardment mass spectometry
The formation and the isolation of fluoroboron salts, (D2BF2+)(PF6-), (DD'BF2+)(PF6-) and (D3BF2+)(PF6-)2, have been carried out. 1,8-Diazabicyclo [5,4.0]undec-7-ene (DBU) and 1,5-diazabicyclo[4,3,O]non-5-ene (DBN), extremely strong organic bases, were introduced into the fluoroboron cation systems …
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Development of New Linking Chemistry with the fac-{Re(CO)3}+ Core for Eventual Applications in Radiopharmaceuticals in Imaging and Therapy
… ligands led to the synthesis of several amidine complexes. The challenge of avoiding isomers of amidine complexes was overcome by using C2-symmetrical heterocyclic secondary amines with 6-membered and larger rings to create an amidine substituent bulkier than the amidine CCH3 group. …
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Identification of Roles for Peptidylarginine Deiminases (PADs) In Models of Nervous System Regeneration, Assessing Capacities of Pharmacological PAD Inhibitor Application
… PAD inhibitors, the pan-PAD inhibitor Cl-amidine (with preference for PAD1, PAD3 and PAD4 inhibition), AMF30a (PAD2 inhibitor) and GSK199 (PAD4 inhibitor), were assessed under normal, hypoxic, and LPS stimulation conditions to evaluate their impact on CNS regeneration and …
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Stabilization of weakly charged microparticles using highly charged nanoparticles
… and comparisons between positively charged amidine latex nanoparticles and negatively charged sulfate latex nanoparticles indicate that the degree of coverage plays an important role in the restabilization. The sulfate latex nanoparticles do not cover the surface sufficiently, and though …
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Kinetic Characterization of the Protein Arginine Deiminase Family: Mechanistic and Inhibition Studies
… and synthesis of PAD4 inhibitors, F- and Cl-amidine, has been described. Herein, we have characterized the catalytic mechanisms of PADs 1, 3, and 4 by kinetic analysis and have identified the mechanism of PAD inactivation by F- and Cl-amidine. Furthermore, the goal of identifying novel lead …
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Spectroscopic investigation of photo-induced proton-coupled electron transfer and Dexter energy transfer in model systems
… the interface exists in the non-ionized (i.e. amidine-carboxylic acid) or ionized (i.e. amidinium-carboxylate) form. Strategies to spectraIIy monitor the interface ionization state by extending electronic communication from a porphyrinic chromophore to its pendant amidinium functionality are …
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The Chemical Synthesis of Model Catalysts Related to Enzymes
… reaction which involved the condensation of amidines with α-haloketones. The reactants required were ethyl 2-carbobenzoxamido-4-oxo-5-chlorovalerate and N<sup>α</sup>-acetyl-N<sup>ε</sup>-tosyl-lysine amidine, both previously unknown. The chloromethylketone was synthesized from α-ethyl …
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Reaction of CS2 and CO2 with Amidines and Guanidines
Neutral organic bases such as amidines and guanidines are very useful in studies of the reactivity of heterocumulenes such as carbon disulfide (CS2) and carbon dioxide (CO2) to build C-C or C-N bonds. Reaction of amidines with CS2 in the absence of water and without adding desulfurization reagents …
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Palladium-catalyzed C-N cross-coupling reactions toward the synthesis of drug-like molecules
… on the cross-coupling of aryl halides with amidine salts. For this cross-coupling, a methodology has been developed that can be applied to various electron-rich, electron-poor, and electron-neutral substrates. Furthermore, the products of this cross-coupling can be used for a subsequent …
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An investigation into the molecular recognition and sensing of anions, especially of alkylcarbamates and related species
… salts and the CO2 adduct of a cyclic amidine, in an investigation into novel CO2 fixation strategies. Chemical shift changes were used to observe relative binding strengths for interactions between the alkylcarbamate and the receptors in DMSO-d6. The results show that it is possible to …
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The monophosphaamidine functional group
… characterization of two new bulky N,P-monophosphaamidines (also known as C-aminophosphaalkenes) are described. These phosphorus analogues to amidines are shown to exhibit isomerism and tautomerism in solution that is characteristic tothe amidine functional group. In addition, the nature of the …
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Controlling Colloidal Stability using Highly Charged Nanoparticles
… used polystyrene latex with either sulfate or amidine surface groups. Effective zeta potentials were measured with nanoparticle concentrations ranging from 0.001% to 0.5% vol. Adsorption levels were determined through direct SEM imaging of the silica microparticles, showing that the …
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CO2-Triggered Switchable Solvent Systems and Their Applications
… the continuation of previous work with using an amidine and alcohol mixtures as a switchable polarity solvent. The second project was the development of a new switchable polarity solvent that is based on the reaction of a secondary amine with CO2. Both solvent systems are fully characterized by …
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Synthetic and mechanistic investigation of new radical processes: reaction of organic azides with group-XIII Lewis acids
… for the attractive synthesis of interesting amidine compounds in the absence of both toxic reagents and tedious purification procedures. Allylindium dichloride seems a good substitute for dichloroindium hydride for generation of indium centred radicals under photolytic conditions, since it …
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Synthesis of heterocycles via isocyanide-based multi-component reactions
… system which enables the formation of an amidine intermediate. This intermediate then cyclises into the oxazoline. This reaction was performed on several aromatic systems, electron-rich or electron-poor, and appeared to be very tolerant of substitution pattern. The extension of these …
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Part I. Anionic Acyl Transfer Catalysis;Part II. Enantioselective alcoholysis of Acyl Donors;Part III. Enantioselective N-acylation
… to 2009, our group developed four generations of amidine-based enantioselective acyl transfer catalysts(ABCs) and applied them successfully to the kinetic resolution of chiral alcohols. Compared with chiral alcohols, the kinetic resolution of chiral acyl donors is more complicated and far less …
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