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Showing 1 to 10 of 10 for “"Amide bond formation"”.
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The development of novel organocatalytic and transition-metal catalysed methodologies for amide bond formation
With the formation of amide bonds being one of the most widely performed reactions within organic chemistry, highly efficient and atom economical approaches enabling the transformation are desired. Traditional methodologies, in which a stoichiometric coupling reagent is utilised, although …
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Mechanisms of Non-Enzymatic Peptide Bond Formation: Thioester and Transamidation Routes
… employed during non-ribosomal peptide (amide) synthesis in the non-ribosomal modular enzyme complex and in the enzyme glutaminyl cyclase were also used for spontaneous peptide (amide) synthesis in a buffered, abiotic solution. Analytical analyses revealed that spontaneous peptide (amide) …
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Automated flow peptide synthesis
… to solid phase polypeptide synthesis with amide bond formation in seven seconds and total synthesis times of forty seconds per amino acid residue. Crude peptide purities and isolated yields were comparable to standard batch solid phase peptide synthesis. Process monitoring with absorbance …
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Development of Pd Catalyzed Amidations & Applications to the Synthesis of Heterocycles
<p>Chapter 1</p> <p>A brief overview of C-N amide bond formation: past methods and current catalytic approaches.</p> <p>Chapter 2</p> <p>A facile synthesis of imidazo[4,5-b]pyridines and -pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to …
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Development and application of methods for analysis of fungal glycosphingolipid structure and functional interactions
… possibility that glycosylinositol phosphorylceramides (GIPCs) could be endogenous ligands of such fungal lectins, structural characterization of glycosphingolipids (GSLs) from the fruiting bodies of these mushrooms was performed. The extraction, isolation and purification of the lipids, and …
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Covalent Modification that Enhances Protein Properties and Functions and Folds Random Coil into Alpha-Helix
… with alditols (organic kosmotropes), via an amide bond using the traditional N-hydroxysuccinimide (NHS) activated carboxylic acids or via an efficient water-driven ligation generating a squaramide linkage. Conjugating such organic kosmotropes to proteins via a squaramide linkage, results in …
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Biosynthetic studies of lincomycin A, a thiosugar-containing natural product
… and investigate the mechanism of the transformations involved in the biosynthetic pathway. Based on the results of early feeding experiments and bio-informatic analysis of the biosynthetic gene cluster, a biosynthetic pathway of lincomycin could be proposed. The enzymes predicted to be …
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Continuous flow processes on single magnetic and diamagnetic particles in microfluidic devices
… and assays. The setup was used to demonstrate amide bond formation and polyelectrolyte deposition in continuous flow, before being used to detect clinically relevant levels (5 and 10µg mL-1) of the inflammatory biomarker, C-reactive protein. Thus, these findings show great potential for rapid, …
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Peptide Mediated Co-assembly of Porphyrin: Towards Sustainable Biomaterials for Light Harvesting and Catalysis
… and condensation of precursors to form peptide bonds <em>in-situ</em> can generate thermodynamically optimized conformations. These well-ordered nanostructures can act as scaffolds to effectively incorporate functional molecules (porphyrins as explained in chapters 3-5), <em>via</em> …
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Towards the Total Synthesis of Antascomicin B. Efforts to Construct the C1-C21 Fragment
… the preparation and rearrangement of an allylic amide possessing a silyloxy group at the terminal position of the alkene. The Tsunoda-Claisen rearrangement uses inexpensive (S)-α-methylbenzylamine as the chiral auxiliary. The allylic amide underwent rearrangement to establish the C14 and C15 …