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Showing 1 to 6 of 6 for “"Amide Synthesis"”.
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Application of Density Functional Theory to Study the Mechanism of Alkali Metal Enolate Oxidation by N-sulfonyloxaziridines, Umpolung Amide Synthesis from Halo-Amino-Nitro Alkanes, Alkali-Metal Catalyzed Transfer Hydrogenation of Ketones, and Asymmetric Catalyzed Aza-Henry Reactions
… SN¬1 rather than SN¬2 like fashion. (2) umpolung amide synthesis working from 1,1,1,1-halo-amino-nitro-alkanes leading to the finding that the amide oxygen originates from the nitro group but also from explicitly interacting water molecules in competing pathways. (3) alkali (Li+, Na+, and K+) …
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Mechanisms of Non-Enzymatic Peptide Bond Formation: Thioester and Transamidation Routes
… employed during non-ribosomal peptide (amide) synthesis in the non-ribosomal modular enzyme complex and in the enzyme glutaminyl cyclase were also used for spontaneous peptide (amide) synthesis in a buffered, abiotic solution. Analytical analyses revealed that spontaneous peptide (amide) …
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PART I: INVESTIGATION OF ENDOCYCLIC NUCLEOPHILIC SUBSTITUTION AT DI- AND TETRA-COORDINATE SULFUR PART II: SYNTHESIS OF 3-TOSYL-1,2,3-BENZOXATHIAZOLE-2,2-DIOXIDE AND ITS REACTIONS WITH NUCLEOPHILES
… and N-methyl-N-(2'-aminobenzyl)-4-toluenesulfonamide, all of which appeared capable of undergoing endocyclic nucleophilic substitution at sulfur, were synthesized. Each compound was treated with the strong base (sodium hydride or n-butyllithium) in THF. No trace of the hoped-for base-induced …
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Pericyclic reactions in organic synthesis
… alternative to conventional solvents for the synthesis of a variety of carboxylic amides. The addition of amines to ketenes generated in situ via the retro-ene reaction of alkynyl ethers provides amides in good yield, in many cases with ethylene as the only byproduct of the reaction. With the …
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ENZYME ENGINEERING AND GREEN SYNTHESIS OF N-ACYL GLYCINE BIOSURFACTANTS FROM RENEWABLE RAW MATERIALS
Amide syntheses remain a key challenging green chemistry reaction. For instance, green synthesis of N-acyl glycines as biosurfactants and therapeutics is highly desirable to replace chemical pathways using toxic phosgene. Herein, we report a novel concept for enzymatic amidation in an aqueous …
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Synthesis and reactivities of titanocene-oxo complexes and rhodium-catalyzed oxidative amidation
… The first part of this thesis focuses on the synthesis of terminal titanium–oxo complexes supported by cyclopentadienyl ligands and their reactivity toward unsaturated organic substrates. The research objectives are: (i) Develop new methods for the preparation of Cp*2Ti=O(L) and Cp’2Ti=O(L) …