Global ETD Search
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Showing 1 to 3 of 3 for “"Amide Bond Cleavage"”.
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DNA catalysts for amide bond cleavage and for lysine side chain modification
… be extensive. Protease enzymes, which catalyze cleavage of proteins, are essential enzymes for biotechnology. Engineering of natural proteases to change their site of cleavage is an exciting prospect, but this process usually leads to relaxed substrate selectivity, rather than a true change in …
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Designed Bond Cleavage Reactions for Next-Generation Therapeutics
… The first project focuses on a metal-mediated amide bond-cleavage reaction from a pentenoic group by using Au salt (Na[AuCl4]) for prodrug activation in aqueous systems. Central to this strategy is a cyclisation step involving the formation of a 5-membered ring intermediate that undergoes rapid …
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Nitrosative guanosine deamination : pyrimidine ring opening implications of effects in homogeneous solution as well as anisotropic environments
… dediazoniation is accompanied by concomitant amide bond cleavage and leads to the pyrimidine ring-opened intermediate 5-cyanoimino-4-oxomethylene-4,5- dihydroimidazole via our proposed pathway. Addition and recyclization chemistry of the intermediate could explain the formations of all known …