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Showing 1 to 9 of 9 for “"Amidases."”.
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Fatty-acyl amidases from the slime mold Dictyostelium discoideum specific for bacterial lipopolysaccharide
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1982
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Synthesis of enantio-pure amides by reversal of the Geobacillus pallidus RAPc8 amidase hydrolysis reaction in non-aqueous media
Amidases are hydrolytic enzymes that catalyze the hydrolysis of amides to their corresponding carboxylic acids and ammonia. Amidases are ubiquitous in nature, and they have been isolated from a wide range of microorganisms, the most common source being bacteria. Amidases are recognized as potential …
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Remodelling of Mycobacterial Peptidoglycan During Cell Division and the Epigenetics of Macrophages during M. tuberculosis infection
… progression and host responses. Mycobacterial amidases have been shown to have important roles in the remodelling of PG during cell division in M. smegmatis and are implicated in sensitivity to antibiotic treatment. However, their roles in modulating host immunity remain unknown. Herein, we …
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The crystal structure of an aliphatic amidase from Geobacillus pallidus RAPc8
Amidases are a group of carbon-nitrogen hydrolysing enzymes that catalyze the conversion of amides to corresponding carboxylic acids and ammonia. These enzymes are of great interest in synthetic industries where they are used for mass production of acidic products. Aliphatic amidase from …
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Production and characterization of a phage endolysin with putative antimicrobial activity against Cutibacterium acnes
… endolysins of phages targeting C. acnes are amidases. Expression of the recombinant proteins could only be detected for the strains containing the pBAD-GFP vector and not the pET11a vector. The antimicrobial activity of endolysin-fusion protein was inconclusive, as the impact on the growth of …
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PEPTIDOGLYCAN REMODELLING FACTORS: KEY PLAYERS IN CELL DIVISION AND HOMEOSTASIS MAINTENANCE OF ESCHERICHIA COLI
… cell separation. This process is mediated by PG amidases, AmiA, AmiB, and AmiC, that are activated by LytM-domain proteins both from inside the cell, with the periplasmic protein EnvC that is anchored to the divisome components FtsEX, and the outside of the cell thanks to the OM lipoproteins NlpD …
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Chemical Probes and Strategies to Study Mycobacterial Cell Envelope Assembly
… amide prodrugs activated intracellularly by amidases. One prodrug exhibited improved efficacy in Mtb, providing a promising lead for antibiotic development. Collectively, these studies establish biosynthetic labeling and targeted galactan inhibition as powerful tools for dissecting the …
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Analysis of the Roles of the cwlD Operon Products during Sporulation in Bacillus subtilis
… similarities to N-acetyl muramoyl-L-alanine amidases, a class of enzymes known to cleave the bond between the peptide side chain and the N-acetyl muramic acid residue in cortex peptidoglycan formation during sporulation. A major difference between vegetative peptidoglycan and spore …
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N-Acylethanolamine Metabolism During Seed Germination: Molecular Identification of a Functional N-Acylethanolamine Amidohydrolase
N-Acylethanolamines (NAEs) are endogenous lipid metabolites that occur in a variety of dry seeds, and their levels decline rapidly during the first few hours of imbibition (Chapman et al., 1999, Plant Physiol., 120:1157-1164). Biochemical studies supported the existence of an NAE amidohydrolase …