Global ETD Search
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Showing 1 to 3 of 3 for “"Amhr2"”.
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Genetic Regulation of Müllerian Duct Regression
… from the fetal testes, to its primary receptor AMHR2 in the MD mesenchyme. This is evidenced by experiments in which male knockout mice that did not express either <em>Amh</em> or <em>Amhr2</em> did not undergo MD regression. Thus, <em>Amh/Amhr2</em> are essential for male sex differentiation. A …
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The role of Wt1 in Müllerian duct development
… suggested that WT1 acts as an activator for <em>Amhr2</em>, a necessary component of typical male differentiation. We used the mouse as a model to investigate the role of WT1 in sex development, where we deleted <em>Wt1</em> in the Müllerian duct (MD) mesenchyme using a novel conditional null …
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On Two Problems in Comparative Genomics of Eukaryotes
… of anti-Müllerian hormone type-2 receptor (AMHR2). AMHR2 inhibits ovarian follicle recruitment and growth, and my results show that its longevity-selected positions cluster near a SNP associated with delayed human menopause. Distinct from its canonical role in development, this region of …