Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Ambient ionization"”.
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Ambient ionization - mass spectrometry: Advances toward intrasurgical cancer detection
… research has focused on the development of ambient ionization – mass spectrometry (MS) for clinical measurements, specifically intrasurgical cancer detection. The molecular differences between normal and cancerous tissue were detected via direct tissue analysis in vitro by touch spray …
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Molecular diagnosis of cancer using ambient ionization mass spectrometry
… on advancing the development and application of ambient ionization mass spectrometry methodology and technology to the biomedical field. The primary ambient ionization method used in my studies is desorption electrospray ionization mass spectrometry (DESI-MS) imaging, which has been previously …
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Ambient Ionization Mass Spectrometry Analysis Pertaining To Biofuel Process Development
… the introduction of a new group of desorption/ionization (DI) techniques known collectively as Ambient Ionization mass spectrometry. Ambient ionization mass spectrometry allows for direct analysis of analytes and typically requires little or no sample preparation. Specifically, Direct Analysis …
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Characterization, Imaging and Quantitation of Small Molecules by Ambient Ionization Mass Spectrometry
… For direct analysis of a sample of interest, ionization techniques such as DESI, PS, MALDI, etc are incorporated into the front of the mass spectrometer. In this work, the ambient ionization techniques, DESI-MS and PS-MS was modulated for characterization, imaging and quantification of small …
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Approaching the Complexity of Biological Specimen: New Mass Spectrometry Concepts in Ambient Ionization and Proteomics
… specimen. Herein, two MS techniques in ambient ionization and proteomics are utilized to explore new concepts in food samples. First, a proof-of-concept is carried out with the liquid micro-junction surface sampling probe (LMJ-SSP), a liquid extraction-based ambient ionization probe, by …
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Development Of A Field-Portable Miniature Mass Spectrometer Designed For In-Situ Analysis And Ion Trap Miniaturization
… vacuum systems, mass analyzers, electronics, and ionization sources have allowed for the development of field-portable mass spectrometers. The performance of portable instruments has received much attention for their utility in the detection of illicit drugs, explosives, environmental …
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Paper spray mass spectrometry (PS-MS) for toxicological drug screens and biomonitoring of chemical warfare agent exposure
Paper spray is an ambient ionization technique for mass spectrometry that is well-known for its ability to accomplish rapid and sensitive analyses without any need for sample preparation. This work further develops the technique in two major areas: negative ionization and drug screening. Negative …
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Instrumentation, Applications And Fundamentals Of Plasma Ionization Of Organic Molecules From Surfaces
… the interaction of low-temperature plasma (LTP) ambient ionization with organic molecules and surfaces are discussed. As an application, LTP-MS has been used for the analysis of pesticides directly from fruits and vegetables revealing low parts per billion limits of detection (LODs). Due to low …
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Quantitation of Anti-Infectious Disease Molecules Utilizing Paper Spray Mass Spectrometry
… outcomes in serious infection. Paper spray ionization (PS), an emerging ambient ionization technique for clinical settings, demonstrations a wide versatility both in analyte variety and applications. This technique offers a rapid, accurate method to analyze these compounds with low rates of …
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Development of enabling technologies for single cell analysis with mass spectrometry
… cells efficiently. A variety of microprobe ionization sources are suitable for such analyses, though smaller probe footprints can utilize more densely seeded samples. This dissertation describes two technologies for performing single cell analysis with mass spectrometry. The first, …
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Structural elucidation of glycerophospholipids using metastable atom-activated dissociation mass spectrometry (MAD-MS)
… of high-energy helium metastable atoms. Penning ionization of the lipid ions causes fragmentation throughout the lipid molecules and provides many radical-induced and high-energy products that are not typically observed through collisional activation. MAD is therefore useful in that it can …
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Surface Acoustic Wave Nebulization as a Mass Spectrometry Ionization Source, Characterization and Application
… of SAWN is lower compare to electrospray ionization (ESI). To improve the SAWN performance, a standing wave SAWN chip was designed and fabricated. The droplet size of standing wave SAWN was measured and is in general smaller than progressive wave SAWN. The standing wave SAWN design …
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Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)
… of liquid sample desorption electrospray ionization mass spectrometry (DESI-MS), a new ambient ionization method with focus on the direct analysis of liquid samples. A variety of new applications of liquid sample DESI are discussed in details including protein conformation study, fast …