Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Alzheimers Disease"”.
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The Total Synthesis of () 7-HDHA
… PPARs mechanism of effects and related diseases (Alzheimers disease, cerebral ischemia, retina inflammation, etc.), the study of 7-HDHA in relation to PPARs has been hampered by the high cost and limited supply of 7-HDHA. The total synthesis of 7-HDHA was attempted using four different …
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DEVELOPMENT OF IMPROVED ARTERIAL SPIN LABELING METHODS IN HUMANS AND ANIMAL MODELS
… and as a research tool for brain injury and Alzheimers disease. Multi-TI ASL makes it possible to measure CBF and arterial transit time (ATT). First, multi-TI ASL is optimized for a swine model. For human applications, limitations of current multi-TI ASL techniques include low SNR, …
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Natural variation in the human plasma lipidome signature using mass spectrometry: relevance to healthy ageing
… and the associated increase in neurodegenerative diseases has made brain health an important research priority. Lipidomics, a subfield of omics, involves characterisation and quantification of total lipids in biological systems. Since brain lipids influence protein function and synaptic throughput …
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Hypernasal Speech Analysis via Emperical Mode Decomposition and the Teager-Kasiser Energy Operator
… to be linked to nervous system disorders such as Alzheimers disease and particularly Parkinson's disease. One can therefore envision the need to not only find a reliable method for detecting hypernasality, but to also quantify the level (severity) of hypernasality as well. An integral component in …
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Imaging of mice and men; adventures in multispectral imaging
… practically imaged intraoperatively to establish disease state. Secondly the redox state of haemoglobin is known to affect it's visible and near-infrared spectral characteristics. This project investigates whether it is possible to identify the haemodynamic response associated with functional …
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Effects of Osmolytes on Amyloid-beta Protein Surface Activity and Membrane Interactions
… to the pathogenesis of over 20 neurodegenerative diseases. Specifically, the toxicity and neurodegenerative symptoms of Alzheimers disease are directly related to the aggregation of the amyloid-β (Aβ) protein into β-sheet rich insoluble fibrils. However, the mechanism and driving forces of Aβ …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… been observed in post mortem brains of Alzheimer Disease (AD) patients accompanied by a decrease in nerve growth factor (NGF)-responsive cholinergic neurons. I report a synergistic effect of the cytokine tumor necrosis factor alpha (TNFa) and NGF on expression of nitric oxide synthase (NOS), in …
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The Alzheimer's Disease Life Events Study
The Alzheimer's Disease Life Events study examines whether there is a relationship between life events and Alzheimer's disease (AD). The ADLE study uses a mixed methods approach to answer the central research question:Are life events a risk factor for Alzheimer's disease? The central research …
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Apolipoprotein E genotypes and Alzheimer disease in two black population groups
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Biomarkers of oxidative stress in models of schizophrenia.
… polyphenolic being tested as a prophylactic in Alzheimers disease. Beneficial effects have been reported for adjunctive omega-3 (n-3 series) polyunsaturated fatty acids, with combined intakes of vitamin C and E on both the positive and negative symptoms of schizophrenia. Robust in vitro systems …
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The Mechanisms of Tau Entry to the Cytosol
… cytosol of neurons in several neurodegenerative diseases. In Alzheimer’s disease, tau pathology arises throughout the human brain in a spatio-temporal manner and closely correlates with disease severity. Assemblies of tau have been proposed to transit between cells of the brain in a ‘prion-like’ …
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Foreclosure and Other Essays
<p>My dad had early onset Alzheimer’s disease. I first knew something was wrong with him in 1995. He was 49 then, and I was just about to start the eighth grade. That’s the summer his company backed him into a corner and told him to quit or be fired. He had worked there 14 years. They said his …
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Dementia with Lewy bodies —an Investigation of Cause and Consequence
… neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are other major dementia disorders such as Alzheimer’s disease (AD), vascular dementia, and …
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A Genome-Wide Screen on Modifiers of Tau-Induced Neurodegeneration Using RNAi-Mediated Gene Silencing in Drosophila
Intraneuronale Akkumulationen des Tau-Proteins sind ein gemeinsames Merkmal der sogenannten Tauopathien. Frontotemporale Demenz und Parkinsonismus des Chromosoms 17 (FTDP-17) ist eine Tauopathie, die durch verschiedene Mutationen in dem für Tau kodierenden Gen verursacht wird. Die Pathologie von …