Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Alzheimers"”.
-
The Total Synthesis of () 7-HDHA
… PPARs mechanism of effects and related diseases (Alzheimers disease, cerebral ischemia, retina inflammation, etc.), the study of 7-HDHA in relation to PPARs has been hampered by the high cost and limited supply of 7-HDHA. The total synthesis of 7-HDHA was attempted using four different strategies, …
-
An Applied Neurobiological Model Of Dance, Why It Matters, And How It Heals
… conditions such as Parkinsons and Alzheimers (PD/AD) diseases are growing, with reported benefits including physical, cognitive, and affective improvements. This is not a new phenomenon; throughout history in cultures around the world, dance has played a role in promoting health and …
-
DEVELOPMENT OF IMPROVED ARTERIAL SPIN LABELING METHODS IN HUMANS AND ANIMAL MODELS
… and as a research tool for brain injury and Alzheimers disease. Multi-TI ASL makes it possible to measure CBF and arterial transit time (ATT). First, multi-TI ASL is optimized for a swine model. For human applications, limitations of current multi-TI ASL techniques include low SNR, …
-
Natural variation in the human plasma lipidome signature using mass spectrometry: relevance to healthy ageing
… of these lipids had lower odds of developing Alzheimers disease. A small proportion of lipids showed significant heritability, with highest heritability among triglycerides and ceramides (h2 up to 0.59). These results confirm and extend previous findings, suggestive of age and sex as important …
-
Hypernasal Speech Analysis via Emperical Mode Decomposition and the Teager-Kasiser Energy Operator
… to be linked to nervous system disorders such as Alzheimers disease and particularly Parkinson's disease. One can therefore envision the need to not only find a reliable method for detecting hypernasality, but to also quantify the level (severity) of hypernasality as well. An integral component in …
-
Imaging of mice and men; adventures in multispectral imaging
… of other neurodegenerative diseases, such as Alzheimers disease. Remarkably little is known about this class of disease including the specific cause of the neurodegeneration. Prions are a mis-folded protein which have a different conformation than the normal protein. Certain spectral features …
-
Effects of Osmolytes on Amyloid-beta Protein Surface Activity and Membrane Interactions
… the toxicity and neurodegenerative symptoms of Alzheimers disease are directly related to the aggregation of the amyloid-β (Aβ) protein into β-sheet rich insoluble fibrils. However, the mechanism and driving forces of Aβ fibril formation in vivo are still unknown. It has been shown previously …
-
Pharmacological studies of bioactive compounds from medicinal mushrooms in Northeast of Thailand
… biological evaluation such as anti-cancer, anti-Alzheimers, anti-microbial and anti-inflammatory activity carried out. An ethanol crude extract of F. cajanderi showed cytotoxicity against ovarian carcinoma (A2780), prostate carcinoma (LNCap) and breast carcinoma (ZR75-1)with IC50 of 149.70 µg/ml, …
-
Reconstructing the gamma-secretase complex using the MultiBac baculovirus system for expression of heterologous multi-protein complexes
A small 4 kDa peptide, referred to as β-amyloid (Aβ), which characteristically accumulates and is deposited in the Alzheimer‟s disease (AD) brain, is known to play a central role in the disease pathogenesis. The Aβ peptide is generated by proteolytic processing of its larger parent molecule, the …
-
Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
Increased cytokine levels have been observed in post mortem brains of Alzheimer Disease (AD) patients accompanied by a decrease in nerve growth factor (NGF)-responsive cholinergic neurons. I report a synergistic effect of the cytokine tumor necrosis factor alpha (TNFa) and NGF on expression of …
-
Biomarkers of oxidative stress in models of schizophrenia.
… polyphenolic being tested as a prophylactic in Alzheimers disease. Beneficial effects have been reported for adjunctive omega-3 (n-3 series) polyunsaturated fatty acids, with combined intakes of vitamin C and E on both the positive and negative symptoms of schizophrenia. Robust in vitro systems …
-
Progettazione e sintesi di piccoli peptidi coniugati con macrocicli per la diagnosi e la terapia nelle malattie neurodegenerative.
L'identificazione di bersagli biologici idonei per lo sviluppo di nuove strategie terapeutiche e/o la costruzione di nuove molecole con capacità sensoristiche può rappresentare un approccio promettente per la diagnosi e il trattamento della malattia di Alzheimer (AD). L'AD è la malattia …
-
The Alzheimer's Disease Life Events Study
The Alzheimer's Disease Life Events study examines whether there is a relationship between life events and Alzheimer's disease (AD). The ADLE study uses a mixed methods approach to answer the central research question:Are life events a risk factor for Alzheimer's disease? The central research …
-
Apolipoprotein E genotypes and Alzheimer disease in two black population groups
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Classification of 4D fMRI Images Using ML, Focusing on Computational and Memory Utilization Efficiency
Alzheimer’s disease is progressively degenerative with a character of memory loss, mood and behavior changes, and deepening confusion about time and place. It is estimated that worldwide about 50 million people are affected by AD. The lifetime per patient care cost of AD is estimated to be about …
-
The Mechanisms of Tau Entry to the Cytosol
The microtubule associated protein tau forms filamentous assemblies in the cytosol of neurons in several neurodegenerative diseases. In Alzheimer’s disease, tau pathology arises throughout the human brain in a spatio-temporal manner and closely correlates with disease severity. Assemblies of tau …
-
Foreclosure and Other Essays
<p>My dad had early onset Alzheimer’s disease. I first knew something was wrong with him in 1995. He was 49 then, and I was just about to start the eighth grade. That’s the summer his company backed him into a corner and told him to quit or be fired. He had worked there 14 years. They said his …
-
Dementia with Lewy bodies —an Investigation of Cause and Consequence
Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are …
-
The Effects of Music Therapy on Elderly Adults with Dementia
<p>As people age, the brain is more susceptible to changes that diminish cognitive function. In recent years neuroscience has found convergent evidence between music therapy and brain architecture, as it has shown the generation of new connections in the brain or a reorganization and possible …
-
A Genome-Wide Screen on Modifiers of Tau-Induced Neurodegeneration Using RNAi-Mediated Gene Silencing in Drosophila
Intraneuronale Akkumulationen des Tau-Proteins sind ein gemeinsames Merkmal der sogenannten Tauopathien. Frontotemporale Demenz und Parkinsonismus des Chromosoms 17 (FTDP-17) ist eine Tauopathie, die durch verschiedene Mutationen in dem für Tau kodierenden Gen verursacht wird. Die Pathologie von …