Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 74 for “"Alzheimer disease"”.
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The role of transthyretin in Alzheimer disease pathology
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Empiric risk to first-degree relatives of Alzheimer disease patients
… evaluated for 1867 first-degree relatives of 338 Alzheimer Disease (AD) index cases and 1873 first-degree relativesof 351 non-cognitively impaired, non-demented elderly controls. A cumulative lifetime risk of 26.73 ± 4.42% for first-degree relatives of AD cases, while significantly higher than the …
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Apolipoprotein E genotypes and Alzheimer disease in two black population groups
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Statins and Risk of Alzheimer Disease: A Systematic Review and Meta-Analysis
… the effects of statins in the prevention of Alzheimer disease.</p><p>Methods: A systematic review of MEDLINE (PubMed) was performed to identify all available published prospective studies that evaluated the effect of statin treatment on the incidence of Alzheimer disease in individuals with …
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Self-Reported Head Injury: Associated Risk in Mild Cognitive Impairment and Progression to Alzheimer Disease
… onset of neurodegenerative disorders, including Alzheimer disease (AD), but its mechanistic link is not well understood. TBI has been hypothesized to activate a progressive neurodegenerative process, accelerate an already present neurodegenerative disorder, or disrupt neuronal/cognitive reserve …
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Predicting the Rate of Decline in Early Alzheimer Disease: The Role of Neurocognitive Performance Features
Alzheimer disease (AD) is a neurodegenerative disorder that characteristically begins with episodic memory impairment followed by other cognitive deficits over time; however, the course of illness varies, with significant variability in terms of the rate of cognitive decline across affected …
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The effectiveness of physical rehabilitation in the enhancement of proprioceptive and cognitive aspects on Alzheimer disease patients.
Based on the Alzheimer Disease (AD) prevention and slowing down, this study has shown interest in evaluating the effects of Global Postural Re-education (GPR) on the cognitiveness of individuals with AD. OBJECTIVE: It is important to verify that by modifying and improving postural attitudes, a …
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Evaluation of Cerebral Lateral Ventricular Enlargement Derived from Magnetic Resonance Imaging: A Candidate Biomarker of Alzheimer Disease Progression in Vivo
Alzheimer disease (AD) is the most common form of dementia and has grievous mortality rates. Measuring brain volumes from structural magnetic resonance images (MRI) may be useful for illuminating disease progression. The goal of this thesis was to (1) help refine a novel technique used to segment …
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Solution structure and biochemistry of an intramembrane aspartyl protease (IAP)
… been implicated in the pathogenesis of human diseases, such as Alzheimer’s disease, Hepatitis C, malaria and a variety of cancers. Despite their broad medical and biological relevance, structural and mechanistic details of IPs have remained largely obscure. A continuous FRET peptide assay, …
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Combining Attentional Control and Semantic Memory Retrieval: A Sensitive Marker for Early Stage AD and AD-related Biomarkers in Healthy Older Adults
… memory retrieval are sensitive markers of Alzheimer disease: AD). The present study examined the utility of combining measures of attentional control and semantic retrieval within a single task to discriminate healthy aging from early stage AD and show sensitivity to AD biomarkers in …
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IMPATTO DELLA DEPRESSIONE SUL RISCHIO DI PROGRESSIONE DEL MILD COGNITIVE IMPAIRMENT A MALATTIA DI ALZHEIMER
… role of depression on the risk of evolving to Alzheimer disease (AD) among mild cognitive impairment (MCI) subjects. We present the results of a clinical study of 169 MCI. Diagnosis of depression was based on clinical criteria. The endpoint was development of AD. Result: 81 MCI subjetcs …
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Ambiguous Loss For Caregivers of Family Members With Dementia
… and losses shift over the progression of the Alzheimer disease and related dementias, and how caregivers experience ambiguous loss. Five caregivers of spouses with Alzheimer’s disease or related dementias participated in this study, recruited from the Alzheimer’s Society of London and …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… have been observed in post mortem brains of Alzheimer Disease (AD) patients accompanied by a decrease in nerve growth factor (NGF)-responsive cholinergic neurons. I report a synergistic effect of the cytokine tumor necrosis factor alpha (TNFa) and NGF on expression of nitric oxide synthase …
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Correlation of neuropsychological tests with measures of atrophy in the hippocampal area
… ageing, like mild cognitive impairment (MCI) and Alzheimer disease (AD) are important to understand and diagnose. A variety of sources, for example neuropsychological testing and MTA biomarker are used to diagnose AD and MCI. However, limited research has been done on the MTA as a biomarker for …
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Improving dementia patient quality of life (QoL) by utilizing augmented reality mobile application
… for other similar memory function challenges disease (Alzheimer disease (AD)).
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Occupancy monitoring and prediction in ambient intelligent environment
… people with health problems like dementia and Alzheimer disease are amongst the applications of such an environment. In the research, environments are considered in different scenarios based on the complexity of the problem including single-occupant and multiple-occupant scenarios. Using simple …
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Intraindividual Variability as a Correlate of White Matter Decline
<p>Aging and early-stage Alzheimer disease (AD) have been associated with increased reaction time intraindividual variability (IIV). In previous studies this age-related increase in IIV has been associated with white matter volumes and microstructure. However, the association between IIV and white …
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Characterization of a novel interaction between presenilin-1 and monoamine oxidase-A
… such as depression and neurodegenerative diseases. Our laboratory has recently demonstrated that increases in calcium (Ca²⁺) can enhance MAO activity and that this might contribute to Alzheimer disease (AD). AD has been linked to gain-of-function mutations in the presenilin-1 (PS-1) …
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Two Sides of The Same Coin in The Levodopa Treatment of Parkinson's Disease
Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder. PD is a characterized by selective loss of dopaminergic neurons in the pars compacta of the substantia nigra. Levodopa (L-dopa) and dopamine agonists have been most commonly used for symptomatic treatment. Since its …
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