Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Alzheimer’s diseases"”.
-
Protein-lipid interactions in molecular pathways of Parkinson’s and Alzheimer’s diseases
Alzheimer’s and Parkinson’s (AD and PD) diseases, increasingly prevalent and currently incurable neurodegenerative disorders, are characterised by the accumulation of proteinaceous pathogenic inclusions in the central nervous system. The key proteins involved in the pathogenesis of AD and PD are …
-
Mitigating protein aggregation to reduce the toxicity inherent to Parkinson’s and Alzheimer’s diseases
… of more than 40 human pathologies, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Misfolded protein oligomers formed as intermediates during the aggregation process have been strongly implicated in the onset and progression of these diseases. In this thesis, I describe our …
-
DIFFERENTIATION OF NEURAL STEM CELL USING SMALL MOLECULES IN 2D AND 3D CULTURE SYSTEM
… potential for the treatment of neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). In this regard, discovering compounds that direct differentiation of NSCs is highly required to facilitate therapeutic applications. In this study, we examined various bioactive compounds (SA1, …
-
Accelerated simulations and computer-aided drug design of membrane proteins
… of these proteins result in deadly human diseases, such as paralysis, cancer, heart failure and Alzheimer’s diseases (AD). Despite the importance, the structural dynamics and functional mechanisms of many membrane proteins remain poorly understood, which has greatly hindered effective drug …
-
On transient assemblies in amyloid formation: mechanistic insights and therapeutic strategies
… is a common feature in over fifty human diseases, including neurodegenerative disorders. While the accumulation of amyloid fibrils hallmarks diagnoses of these conditions, pre-fibrllar oligomers are increasingly recognised as the major toxic agents. However, these assemblies pose …
-
Role of P2Y12 receptor-mediated ADP signalling at microglia in the phagocytosis of neurons
… disorders such as Parkinson’s and Alzheimer’s diseases, surprisingly little is known about the molecular mechanisms governing widespread neuronal loss observed in these conditions. Recent studies, however, have linked heightened microglial phagocytosis of live neurons under …
-
Effects of Natural Antioxidants on Motor and Cognitive Deficits in an Animal Model of Aging and Obesity and Dopaminergic-Like SH-SY5Y Cell Line
… neurodegenerative disorders like Parkinson’s and Alzheimer’s diseases, there is a pressing need to address deficits associated with normal aging.</p> <p>Increase in oxidative stress and a decline of antioxidant mechanisms with aging have been attributed to the incidence of deteriorated physical …
-
Interaction between Adrenergic and Nitric Oxide-releasing Nerves in Cerebral Arteries
… Sclerosis, Schizophrenia, Parkinson’s and Alzheimer’s diseases. On the other hand, beneficial effects of NO include a role in synaptic plasticity and modulation of sympathetic nerve activity in cerebral arteries with potential to modulate cerebral circulation.</p> <p>This thesis provides …
-
Discovery of heat shock protein90 inhibitors using structured-based virtual screening
Alzheimer's disease (AD) is the most common irreversible dementia, caused by accumulation of protein aggregates in the central nervous system, with symptoms that include memory loss and behavioural abnormalities. Cholinesterase inhibitors (ChEIs) and N-methyl-D-aspartate receptor (NMDAR) …