Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 317 for “"Alzheimer’s disease (AD)"”.
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A Deep Learning Pipeline for Classifying Different Stages of Alzheimer's Disease from fMRI Data.
Abstract Alzheimer’s disease (AD) is an irreversible, progressive neurological disorder that causes memory and thinking skill loss. Many different methods and algorithms have been applied to extract patterns from neuroimaging data in order to distinguish different stages of AD. However, the …
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Investigating Diffusion Tensor Imaging Correlates of Cognitive Impairment In Idiopathic Normal Pressure Hydrocephalus and Alzheimer'S Disease
… and may be comorbid with other neurodegenerative diseases such as Alzheimer’s disease (AD) or frontotemporal dementia (FTD). Clinically, it can be difficult to tell whether the pathophysiological changes leading to cognitive impairment also led to the ventriculomegaly, as may occur in AD, versus …
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Effect of anti-microbial immunizations in the progression of amyloid and neuroinflammatory pathologies in a mouse model of Alzheimer's disease
<p>Alzheimer’s disease (AD) is the most common type of dementia. The complexity of AD is reflected in the multiple factors that can contribute to preventing or promoting the biological drivers of AD, namely amyloid-beta (Aβ) aggregation, tau deposition in the brain, and neuroinflammation. While the …
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THE RELATIONSHIP BETWEEN BRAIN AND SYSTEMIC METABOLISM IN ALZHEIMER’S DISEASE AS ASSESSED BY DUAL-TRACER ACETOACETATE/FLUORODEOXYGLUCOSE PET IMAGING
Alzheimer’s disease (AD) is a fatal neurodegenerative disorder that afflicts an estimated 5.4 million people in the United States. Cerebral metabolic dysfunction is a well-established feature of AD. Despite an established relationship between systemic metabolic disease and AD we know very little …
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Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models
<p>Mouse models of Alzheimer’s disease (AD) that accurately recapitulate pathology and molecular changes are crucial for understanding disease mechanisms and subsequent therapeutic development. We examined five commonly used mouse models of AD (5xFAD, J20, APPNL-F, APPNL-G-F, Tau P301S) and …
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Emerging adulthood and willingness to caregive
… on caregiving experiences for relatives with Alzheimer’s disease (AD). However, virtually no research exists on the factors associated with willingness to caregive before entering the caregiver role. Furthermore, little is known about caregiving during emerging adulthood despite the unique …
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Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change
… peptides in the brains small blood vessels leading to hemorrhagic stroke and cognitive impairment. Aβ is toxic to smooth muscle cells and impairs blood flow regulation. Reduced blood oxygen level dependent (BOLD) signal amplitude in response to a visual fMRI task has recently been implicated …
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Transcranial direct current stimulation in Alzheimer's disease
… direct current stimulation (tDCS) treatment of Alzheimer’s disease (AD) into a machine learning model of the disease to understand the long term impact of the treatment on disease progression over a decade. The three main contributions of this work are: Firstly, this work proposes the extension …
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Measuring Memory in an Alzheimer's Treatment Trial Using a Visual Search Task
Alzheimer’s Disease (AD) is characterized by episodic memory deficits attributed to damage to the hippocampal formation. AD therapies specifically targeting hippocampal function may be best evaluated through the use of selective hippocampal tasks. I used a nonverbal hippocampal-dependent …
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RANDOMISED CONTROLLED TRIALS ON PSYCHOLOGICAL INTERVENTIONS TO PROMOTE MENTAL HEALTH OF COMMUNITY-DWELLING ELDERLY
Introduction: Contradicting reports on peripheral BDNF levels in patients with dementia and the dearth of literatures on how mindfulness intervention and horticultural therapy may modulate cognition and psychological well-being, prompted us to initiate two randomized-controlled trials. Methods: …
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Examining the binding of humanin and acetylcholinesterase with amyloid beta
… (Aβ) in the development and progression of Alzheimer’s disease (AD) is currently well-recognized. Aβ was recently shown to be protective against certain types of cancer and capable of inhibiting the growth of tumor cells. The mechanisms by which Aβ is converted into functional entities and …
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Deciphering the mechanism by which humanin binding to IGFBP3 inhibits neuronal cell death in alzheimer’s disease
… prerequisite for apoptosis induced by IGFBP3 in Alzheimer’s disease (AD). The neuroprotective peptide humanin (HN) counteracts this IGFBP3-induced cell death. Unfortunately, the natural synthesis of this peptide decreases with age coincident with the time that people are likely to develop AD. In …
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Neuroinflammation in Alzheimer’s Disease Mouse Brain Following Repetitive Mild Traumatic Brain Injury
… brain injuries (TBIs) are a common form of head injury, with mild TBIs (mTBIs) making up 75-90% of the TBI severity scale. It’s been suggested that repetitive mild TBIs (rmTBIs) may enhance effects of Alzheimer’s Disease (AD). With dementia linking TBI and AD together, we investigated the …
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Oxidative stress biomarkers in dementia
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder which is thought to affect 26.6 million individuals worldwide. There is growing concern over a worldwide dementia epidemic that is predicted to develop over the coming decades. The evidence thus far suggests that increased levels …
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In vivo Examination of Peripheral Drivers of Alzheimer’s Disease
<p>Alzheimer’s disease (AD) is the leading cause of dementia worldwide, and predominantly affects elderly populations. This disease is well known for its effects on the brain, but a wealth of clinical reports show that dementia can also modify, or be modified by, various peripheral and systemic …
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Investigation of Riluzole’s Synaptic Protection Mechanism Through HSF1-BDNF Axis
… drug Riluzole has great potential in treating Alzheimer’s disease (AD) based on promising animal data as well as its known action on modulating synaptic transmission. However, its detailed mechanism of action is not fully understood. Here, we proposed work aiming to address this aspect via …
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A study of the elongation of fibrils of the Alzheimer's amyloid beta protein with a coarse-grained force field
Alzheimer’s disease (AD) is a brain disorder named after the German psychiatrist Alois Alzheimer, who first described the disease in 1906. AD is a form of dementia, characterized by impairment of memory and other intellectual abilities, caused by the loss of neurons and synapses (the structures …
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Adaptive, Federated, and Resilient Health Monitoring via Novel Online Collaborative Learning Algorithms
Adaptive monitoring of a large population of dynamic processes is critical for the timely detection of abnormal events under limited resources. This issue is pervasive in various sectors, including healthcare and engineering systems, due to the disparity between available monitoring resources and …
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Ectodomain Mutations Alter the Proteolysis of the Amyloid-β Precursor Protein (APP)
<p>Alzheimer’s disease (AD) is the most common form of dementia, affecting over 5 million Americans. In AD patients there is a buildup of amyloid plaque in the brain, which contributes to AD symptoms. The main component of plaques is Amyloid-β (Aβ), a 40-42 length peptide formed from Amyloid-β …
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Dysregulated DJ1-Mediated Translation in Alzheimer's Disease
Alzheimer’s Disease (AD) is a form of dementia with aberrant synaptic transmission. It has been hypothesized that disrupted calcium signaling may cause the digression from healthy memory to mild cognitive impairment (MCI) and eventually AD; and the search for the source of calcium dyshomeostasis …
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