Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 644 for “"Alzheimer’s disease"”.
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Understanding Cognitive Variability in Alzheimer’s Disease
Alzheimer’s Disease (AD) is highly heterogenous, both clinically and biologically. This variability is exacerbated by the ways within which, the clinical presentation is assessed with cognitive measures. This inhibits clinical trial success and earlier diagnosis of individuals. Marrying the …
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Modelling prognostic trajectories in Alzheimer’s disease
Progression to dementia due to Alzheimer’s Disease (AD) is a long and protracted process that involves multiple pathways of disease pathophysiology. Predicting these dynamic changes has major implications for timely and effective clinical management in AD. There are two reasons why at present we …
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“CLICKED” BIVALENT MULTIFUNCTIONAL LIGANDS IN ALZHEIMER’S DISEASE.
<p>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by beta-amyloid (Aβ) aggregation/oligomerization, biometal dyshomeostasis, oxidative stress, and neuroinflammation. The multifactorial nature of AD may indicate the therapeutic potential of multifunctional ligands that tackle …
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Iron Dysregulation and Inflammation in Alzheimer’s Disease
<p>Alzheimer’s disease (AD) is the most common form of senile dementia in the US and worldwide but the causes of its pathogenesis are currently unknown. In this study, we examined two processes that have been implicated in the early stages of AD and other forms of neurodegeneration, iron …
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Integrative multiomic insights into Alzheimer’s disease pathology
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, currently afflicting around 900,000 patients in the United Kingdom. However, therapeutic avenues and factors that can exacerbate AD pathologies remain unclear. Hence, there is an urgent need for a better …
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Investigating Pathogenic Mechanisms and Biomarkers in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common form of dementia among the elderly and a major public health issue worldwide. Despite decades of research efforts, AD still lacks an effective treatment. Although the first two histopathological markers of AD identified in the 1980’s are brain deposits of …
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Synaptic Excitatory to Inhibitory imbalance in Alzheimer’s Disease
Alzheimer’s disease is the most common cause of dementia worldwide, and it is characterized by progressive impairment of cognitive performance, brain atrophy, neuronal and synaptic loss, and abnormal aggregation of amyloid beta and tau proteins. Notably, prodromal Alzheimer’s disease is …
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Epigenetic Modulation of Synaptic Resilience in Alzheimer’s Disease
… here referred to as Non-Demented with Alzheimer’s Neuropathology (NDAN), retain their cognitive function despite the presence of amyloid plaques and tau tangles typical of symptomatic Alzheimer’s Disease (AD). In NDAN, unlike AD, toxic amyloid beta (Aβ) oligomers do not localize to the …
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TNF inhibitors for the prevention of Alzheimer’s disease
… in the development and progression of Alzheimer's disease (AD). This is of particular relevance in rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease, as these patients have higher levels of systemic inflammation than the general population. If AD is driven by …
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Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease
Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. Efforts to develop effective treatments for humans have mostly been based on the assumption …
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Characterisation of Tau splicing factors in Alzheimer’s disease
… tau, one of the pathological hallmarks of Alzheimer’s disease (AD). Alternative splicing of the tau pre-mRNA produces six tau isoforms with or without exon 10 (E10); tau4R or tau3R, microtubule binding repeats respectively. In normal human brains the ratio of 4R/3R tau is approximately one. …
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Apolipoprotein E4 and SirT1 Interaction in Alzheimer’s Disease
<p>Alzheimer’s disease (AD) is a neurodegenerative disorder whose exact cause(s) are still unknown. Εpsilon 4, an allele of apolipoprotein E (ApoE4), is currently the most important risk factor for Alzheimer’s disease. Individuals that inherit two copies of the ApoE ε4 allele have an approximately …
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scPhen: Single-Cell Phenotype Predictor for Alzheimer’s Disease
… offering a powerful substrate for modeling disease circuitry. However, predicting patient-level phenotypes from scRNA-seq remains challenging due to limited sample sizes, variable cell counts, and the computational burden of modeling long-context dependencies. We present scPhen, a flexible, …
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Reversal of Neurodegeneration By Engineered Monocytes In Alzheimer’S Disease
<p>The health challenges posed by Alzheimer’s disease (AD) continue to grow as societies age worldwide. Accumulation of Tau-associated pathology correlates with clinical cognitive deterioration in AD. Resident myeloid cells within the central nervous system (CNS) have a limited capacity to uptake …
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In vivo Examination of Peripheral Drivers of Alzheimer’s Disease
<p>Alzheimer’s disease (AD) is the leading cause of dementia worldwide, and predominantly affects elderly populations. This disease is well known for its effects on the brain, but a wealth of clinical reports show that dementia can also modify, or be modified by, various peripheral and systemic …
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Modeling the Early Identification and Intervention of Alzheimer’s Disease
… evidence for the pathophysiological process of Alzheimer’s disease (AD) before clinically detectable dementia. Because of these findings, AD research has begun to focus on the preclinical or prodromal stages of the disease. For example, many clinical trials and laboratory-based studied have …
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Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models
<p>Mouse models of Alzheimer’s disease (AD) that accurately recapitulate pathology and molecular changes are crucial for understanding disease mechanisms and subsequent therapeutic development. We examined five commonly used mouse models of AD (5xFAD, J20, APPNL-F, APPNL-G-F, Tau P301S) and …
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Targeting protein kinases to manage or prevent Alzheimer’s disease
<p>Due to the pressing need for new disease-modifying drugs for Alzheimer’s disease (AD), new treatment strategies and alternative drug targets are currently being heavily researched. One such strategy is to modulate protein kinases such as cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase …
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Neuropsychological assessment accuracy in diagnosing early-onset Alzheimer’s disease
<p>Early-onset Alzheimer’s disease (EOAD), a progressive neurological condition, is often difficult to diagnose before substantial neuronal damage. Neuropsychological assessments offer a more cost-effective and accessible method for detecting early cognitive decline, yet limited research exists on …
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iCARE: Identifying caregivers’ Alzheimer’s disease and related dementias experiences
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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