Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Alzheimer´s disease (AD)"”.
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A renewed vision for Amyloid beta and tau in Alzheimer s disease pathophysiology
… to study the pathogenetic mechanisms underlying Alzheimer s disease (AD), a neurodegenerative disorder affecting the elderly and characterized by memory loss, personality changes and cognitive dysfunction leading to dementia. I will discuss the main projects in which I participated aimed at …
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REDOX PROTEOMICS, THIOL HOMEOSTASIS AND NEUROPHYSIOLOGICAL CORRELATIONS IN AGING AND NEURODEGENERATION
… and "neurodegeneration" are often used in a broad and generalized manner. Actually, they are particularly complex and multifaceted processes, involving different biochemical systems. Increasing evidence supports the notion that reduction of cellular expression and activity of antioxidant …
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Exploring retinal changes in Dementia and Multiple Sclerosis
… and monitoring progression of neurodegenerative diseases relies on the assessment of clinical symptoms such as cognitive impairment in Alzheimer`s disease (AD) and disability in Multiple Sclerosis (MS). Detection of molecular and morphological hallmarks in the brain or spinal cord is invasive, …
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Neurotoxicity of environmental pollutants
… some of these chemicals, at low concentrations had amyloidgenic effects causing the cleavage amyloid precursor protein (APP) into Beta-amyloid (Aβ) and could therefore be implicated in Alzheimer‟s disease (AD).
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Progress Towards Development Of Multifunctional, Dopamine D2/d3 Receptor Agonists As Symptomatic And Disease-Modifying Therapeutic Agents For Parkinson's Disease
<p>Parkinson¡¯s disease (PD) is a progressive, neurodegenerative disorder that arises primarily through the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), resulting in a diminished level of the neurotransmitter dopamine in the nigrostriatal pathway and ensuing loss of …
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Effetti protettivi del 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclo-propanecarboxylic Acid (CHF5074) su cellule neuronali sottoposte a stimoli tossici in vitro.
… stimuli in vitro. Nicole Ronsisvalle, Renato Bernadini,Rosa Chillemi Dept of Clinical and Molecular Biomedicine, section on Pharmacology and Biochemistry, Univ of Catania Sch Med, 95125 Catania, Italy Alzheimer¡¦s disease (AD) is the most common form of dementia. The basic pathological …
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Measuring Dementia of the Alzheimer Type More Precisely
Alzheimer?s disease (AD) progressively impairs cognitive and functional abilities. Research on pharmacological treatment of AD is shifting to earlier forms of the disease, including preclinical stages. However, assessment methods traditionally used in clinical research may be inappropriate for …
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The effects of anticholinesterases and β-amyloid pathology on neurotrophin signaling in the mouse brain
Alzheimer s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia. One promising approach to tackle AD is the protection of neurons and restoration of synaptic connections with neurotrophic factors, such as nerve growth factor (NGF) and brain-derived …
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Protective effects of s-propargylcysteine (SPRC) on in vitro neuronal damage induced by Amyloid-Beta (25-35)
Alzheimer?s disease (AD) is a neurodegenerative disease characterized by widespread extracellular deposits of amyloid-beta (A?) protein in the brain. Amongst which, the A?25-35 peptide is the shortest fragment which retains the toxicity of the full-length protein. In this study, this peptide was …
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The role of mTOR signaling in Alzheimer s disease
The majority (>95%) of Alzheimer s disease (AD) cases are sporadic and of unknown causes. The single major risk factor for AD is aging and molecular changes that occur in the brain as a function of age may facilitate the development of AD. However, little is known as to how the aging process …
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Organelle specific mechanisms of neuronal cell death
… accompanies neurodegenerative disorders, such as Alzheimer s disease (AD) and Huntington s disease (HD), epilepsy and ischaemia. Glutamate is the major excitotoxin in the CNS and causes activation of glutamate receptors. Ionotropic glutamate receptors can directly cause calcium influx that further …
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Charakterisierung der Proteinphosphatase 1E (PPM1E) - Lokalisierung und Trunkation in Gehirngewebe und Effekte auf neuronale Morphologie in primärer Neuronenkultur
Die Alzheimer sche Erkrankung (Alzheimer s disease, AD) ist eine progressive, neurodegenerative Krankheit, die durch frühe Defizite im Lernen und Gedächtnis, mit letztendlichem Verlust von höheren kognitiven Funktionen, charakterisiert ist. Obwohl erhebliche Fortschritte im Verstehen der …
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Studies of the cell biological function of the Amyloid Precursor Protein (APP) family in Drosophila melanogaster and mammals
Alzheimer�s disease (AD) is the most common neurodegenerative disorder affecting cognitive functions of the brain, and is pathologically characterized by extracellular Amyloid plaques and intracellular neurofibrillary tangles are the main pathological features of AD. Amyloid-beta, the main protein …
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Reconstructing the gamma-secretase complex using the MultiBac baculovirus system for expression of heterologous multi-protein complexes
… accumulates and is deposited in the Alzheimer‟s disease (AD) brain, is known to play a central role in the disease pathogenesis. The Aβ peptide is generated by proteolytic processing of its larger parent molecule, the amyloid precursor protein (APP). The final stage in this process, …
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Role of psychometric tools in the diagnosis and pharmacological treatment of Major Depression and Alzheimer s disease
… the development of mild cognitive impairment and Alzheimer s disease (AD). According to this clinical continuum between depression, MCI and AD new strategies of neuropsychological assessments should be explored by using multiple psychometric tools able to detect both affective and cognitive …
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The Role of Insulin and Insulin-like Ischemic Stroke and Cognitive Impairment
… life span. In contrast, the role of IGF-II in adult life has been unclear. Animal studies have demonstrated that altered brain activity of the insulin/IGF-system is associated with reduced cognitive function and worse outcome after experimentally induced stroke and this is reversed by …