Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"Alzheimer´s disease"”.
-
The role of mTOR signaling in Alzheimer s disease
The majority (>95%) of Alzheimer s disease (AD) cases are sporadic and of unknown causes. The single major risk factor for AD is aging and molecular changes that occur in the brain as a function of age may facilitate the development of AD. However, little is known as to how the aging process …
-
A renewed vision for Amyloid beta and tau in Alzheimer s disease pathophysiology
… to study the pathogenetic mechanisms underlying Alzheimer s disease (AD), a neurodegenerative disorder affecting the elderly and characterized by memory loss, personality changes and cognitive dysfunction leading to dementia. I will discuss the main projects in which I participated aimed at …
-
ROLE OF LECITHIN:CHOLESTEROL ACYLTRANSFERASE (LCAT) IN BRAIN CHOLESTEROL METABOLISM AND ITS INVOLVEMENT IN ALZHEIMER¿S DISEASE
… is the strongest known genetic risk factor for Alzheimer’s disease (AD), but its ability in activation of LCAT enzyme has never been investigated. Moreover, several epidemiological studies indicate a strong inverse association between the risk of developing AD and plasma HDL-c levels. The …
-
Role of psychometric tools in the diagnosis and pharmacological treatment of Major Depression and Alzheimer s disease
… the development of mild cognitive impairment and Alzheimer s disease (AD). According to this clinical continuum between depression, MCI and AD new strategies of neuropsychological assessments should be explored by using multiple psychometric tools able to detect both affective and cognitive …
-
UNRAVELLING THE MOLECULAR BASIS OF ALZHEIMER¿S DISEASE AND FRONTOTEMPORAL DEMENTIA: GENETIC AND EPIGENETIC APPROACH THROUGH NEXT GENERATION SEQUENCING AND OPENARRAY TECHNOLOGIES
Alzheimer’s disease (AD) and Frontotemporal dementia (FTD) are complex heterogeneous disorders with a strong genetic background, but the identification of a genetic cause is difficult given the multifactorial aetiology of the disorders. Epigenetic and environmental factors interplay to influence …
-
CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS
… of cholesterol are associated with stroke and Alzheimer?s disease, but little is known regarding the effects of cholesterol on gene expression. The present study was therefore carried out using microarray-based approaches to elucidate the effects of cholesterol on gene expression changes in the …
-
REDOX PROTEOMICS, THIOL HOMEOSTASIS AND NEUROPHYSIOLOGICAL CORRELATIONS IN AGING AND NEURODEGENERATION
… in the aging processes and neurodegenerative diseases. Within the frame of free radical hypothesis of aging, several lines of evidence suggest that accumulation of oxidative molecular damage is a causal factor in senescence. It is also increasingly evident that the mitochondrial genome may …
-
Exploring retinal changes in Dementia and Multiple Sclerosis
… and monitoring progression of neurodegenerative diseases relies on the assessment of clinical symptoms such as cognitive impairment in Alzheimer`s disease (AD) and disability in Multiple Sclerosis (MS). Detection of molecular and morphological hallmarks in the brain or spinal cord is invasive, …
-
Applying behavioral management skills training with employees in geriatric care unit to increase social interaction and communication with residents
… with a neurocognitive disorder (NCD, i.e., Alzheimer´s Disease). Due to deterioration of executive functions, such as taking initiative, apathy, a lack of motivation, and agitation, there is an increased risk of in-activity for NCD individuals. Due to the passive environment, these effects …
-
Neurotoxicity of environmental pollutants
… (Aβ) and could therefore be implicated in Alzheimer‟s disease (AD).
-
Progress Towards Development Of Multifunctional, Dopamine D2/d3 Receptor Agonists As Symptomatic And Disease-Modifying Therapeutic Agents For Parkinson's Disease
<p>Parkinson¡¯s disease (PD) is a progressive, neurodegenerative disorder that arises primarily through the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), resulting in a diminished level of the neurotransmitter dopamine in the nigrostriatal pathway and ensuing loss of …
-
Effetti protettivi del 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclo-propanecarboxylic Acid (CHF5074) su cellule neuronali sottoposte a stimoli tossici in vitro.
… Univ of Catania Sch Med, 95125 Catania, Italy Alzheimer¡¦s disease (AD) is the most common form of dementia. The basic pathological abnormalities in AD brains are: amyloid plaques, neurofibrillary tangles and neuronal loss. Amyloid plaques are composed of £]-amyloid (A£]) peptides that are …
-
Protective effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Apoptosis Induced Human Neuroblastoma SH-SY5Y Cells
… in treatment of neurological disorders including Alzheimer…s disease, Parkinson…s disease and stroke. Cell therapy using human bone marrow-derived mesenchymal stem cells (hMSCs) is an attractive tool to alleviate neurological disease We investigate whether culture media of hMSCs and coculted hMSC …
-
Measuring Dementia of the Alzheimer Type More Precisely
Alzheimer?s disease (AD) progressively impairs cognitive and functional abilities. Research on pharmacological treatment of AD is shifting to earlier forms of the disease, including preclinical stages. However, assessment methods traditionally used in clinical research may be inappropriate for …
-
Structure and dynamics of the aggregation mechanism of the Parkinson´s disease-associated protein alpha-synuclein
… von aS, der sogenannten non-A-beta component of Alzheimer s disease amyloid (NAC), zurück und verhindert dadurch eine über diesen Bereich vermittelte Oligomerisierung von aS. Die Stabilisierung der autoinhibierten Struktur findet innerhalb von Nano bis Mikrosekunden statt; dies ist die Zeitskala …
-
The effects of anticholinesterases and β-amyloid pathology on neurotrophin signaling in the mouse brain
Alzheimer s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia. One promising approach to tackle AD is the protection of neurons and restoration of synaptic connections with neurotrophic factors, such as nerve growth factor (NGF) and brain-derived …
-
Protective effects of s-propargylcysteine (SPRC) on in vitro neuronal damage induced by Amyloid-Beta (25-35)
Alzheimer?s disease (AD) is a neurodegenerative disease characterized by widespread extracellular deposits of amyloid-beta (A?) protein in the brain. Amongst which, the A?25-35 peptide is the shortest fragment which retains the toxicity of the full-length protein. In this study, this peptide was …
-
Untersuchung genetischer und geschlechtlicher Einflüsse in der Alzheimerpathologie anhand des Maustiermodells 5XFAD
Die Alzheimerdemenz ist die häufigste Demenzform und betrifft in Deutschland zur Zeit ca. 900.000 Erkrankte. Obwohl seit Alois Alzheimer intensiv an dem Verständnis der Pathogenese geforscht wird, gibt es bis heute keine etablierte kausale Therapie. Neuropathologisch ist die Erkrankung durch intra- …
Page 1 of 2