Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 166 for “"Alzheimer's disease (AD)"”.
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Study of Structural and Physical Properties of Small Molecule and Nanoparticle Inhibitors of Amyloid-B Protein Fibril Formation In Alzheimer'S Disease
<p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia in the elderly. The instances of AD are rapidly increasing and there is no cure currently available for this devastating disease. Current therapies for the disease allow AD patients to delay or …
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Design and Synthesis of Novel Benzimidazoles and Aminothiazoles as Small Molecule Inhibitors of CDK5/p25
… plays an important role in the pathology of Alzheimer's disease (AD). CDK5/p25 has been implicated in hyperphosphorylation of tau protein which forms neurofibrillary tangles (NFTs), a contributing factor to the pathology of Alzheimer's disease (AD). Based on the deposited X-ray crystal …
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Phosphoproteomics analysis of Alzheimer's disease
Alzheimer's disease (AD) is a form of dementia characterized by the appearance of amyloid-[beta] plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Despite numerous clinical trials, a limited understanding of disease pathogenesis has prevented the development of …
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Cognitive resilience is mediated by the MEF2 network in mice and humans
… pathological hallmarks of neurodegenerative disease, a small number of these individuals are able to maintain healthy cognitive function even in the presence of extensive brain pathology. The molecular mechanisms that govern this neuro-protected state remain unknown, but individuals that …
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Cognitive and Non-Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease
… be useful in developing novel treatments for Alzheimer's disease (AD) patients. The Bussey-Saksida touchscreens employ various tasks similar to those used in humans to effectively evaluate high-level cognitive and executive functions in mice. This face validity provides the best chance of …
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Modeling Alzheimer's Disease Using CRISPR/CAS9 Gene Editing and Induced Pluripotent Stem Cells Reveals Conserved Cellular Mechanisms
<p>Alzheimer's disease (AD) is the most common cause of dementia worldwide and a leading cause of death in the United States. Rare cases of autosomal dominant familial AD (fAD) result from genetic mutations in three key genes: amyloid precursor protein (APP), and two APP processing-related genes …
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A Family-Based Association Study of Conduct Disorder.
… (CD) is a psychiatric syndrome in childhood and adolescence that is one of the most common childhood disorders with continuously increasing prevalence but uncertain pathogenesis. We performed a genome-wide, family-based association study of CD using P2BAT/FBAT software. The data is gathered from …
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Modeling Alzheimer's Disease Using Cellular Reprogramming Technologies
… neuronal (iN) cell technology. These recent advances in cell reprogramming strategies have great potential utility for patient-specific disease modeling and for applications in regenerative medicine. Current models of neurodegenerative diseases are limited in their representation of disease …
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Computational studies of tau protein : implications for the pathogenesis and treatment of neurodegenerative diseases
… tangles, a pathological hallmark of Alzheimer's disease (AD). Previous studies suggest that tau protein may play a contributing role in neurodegenerative diseases such as AD. Thus characterizing the structural properties of tau is critical to understanding disease pathogenesis. …
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A streptozotocin-induced model of Alzheimer's disease in mice with wild-type human tau
Alzheimer's disease (AD) accounts for 60 to 80% of all dementias, affects over 5 million Americans, and incurs annual healthcare costs of over {dollar}200 billion (Alzheimer's Association, 2012). Hyperphosphorylation of tau, the main component of neurofibrillary tangles observed in AD, leads to …
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Nicotinic acetylcholine receptors and their interaction with Aβ₁₋₄₂
Alzheimer's Disease (AD) is a progressive, age-related disease that is positively characterised by the post-mortem presence of neurofibrillary tangles and amyloid plaques. At present ~ 5 % of those aged over 65 years are diagnosed with AD, with this figure increasing to ~ 20 % for those aged over …
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The Impact of Insulin signalling on a C. elegans Alzheimer’s Disease Model
Alzheimer's Disease (AD) represents a significant challenge in aging societies. Researchers found a strong correlation with diabetic patients more likely to develop AD. This study explores the interaction between AD and insulin signalling by employing a transgenic Caenorhabditis elegans model …
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Stacked generalization for early diagnosis of Alzheimer's disease
<p>Alzheimer's disease (AD) is a neurological disorder characterized by nerve degeneration and neuronal death. The diagnosis of AD at an early stage is a major concern due to growing number of elderly people affected by the disease, as well as the lack of a standard diagnosis procedure available to …
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Solid-State NMR Characterization of a PET Ligand Binding Sites in AD Tau Fibrils
… the tau protein into fibrils is a key feature of Alzheimer's disease (AD) and many other neurodegenerative disorders. Developing small molecules that bind these tau fibrils is important for the diagnosis and treatment of tauopathies. This thesis revolves around a study on the binding sites of a …
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Using network inference to discover molecular pathways underlying cytokine synergism and age-related neurodegeneration
… shed light on molecular pathways underpinning diseases ranging from cancers to neurodegenerative disorders. However, effectively integrating information across these diverse data types is challenging. Network modeling approaches can help bridge this gap. In particular, the Prize- Collecting …
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Exploring the Effect of Caregiver Burden among Alzheimer's Caregivers: A Test of The Stress Process Model
The diagnosis of Alzheimer's disease (AD) is stressful for both patients and their family caregivers (FCG). As the disease progresses, the patient's memory, functioning status, and behavioral problems get worse, and the needs of the patient that must be addressed by family caregivers increase …
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Multi-modal Multi-Level Neuroimaging Fusion with Modality-Aware Mask-Guided Attention and Deep Canonical Correlation Analysis to Improve Dementia Risk Prediction
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by structural and molecular changes in the brain. Early diagnosis and accurate subtyping are essential for timely intervention and therapeutic planning. This thesis presents a novel multimodal deep learning framework …
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Evaluating activity presentation formats and the amount of interactions to increase activity engagement in older adults with Alzheimer's disease
… to increase activity engagement in eight older adults with Alzheimer's disease (AD) living in a special care unit of a nursing home. Three experiments, each using an alternating treatments design, were conducted. Experiment 1 compared two sets of activities (i.e., standard and novel) on …
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Innovative Alzheimer's disease clinical trial design in the coming age of biomarkers
Alzheimer's disease (AD) is a field with huge unmet need and only a few symptomatic treatments with limited efficacy have been made available to patients. With the testing of disease-modifying drugs in recent years, the length of AD clinical trials has tripled and the enrollment has gone up …
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Evaluating Neuroimaging Modalities in the A/T/N Framework: Single and Combined FDG-PET and T1-Weighted MRI for Alzheimer’s Diagnosis
… escalating prevalence of dementia, particularly Alzheimer's Disease (AD), the need for early and precise diagnostic techniques is rising. This study delves into the comparative efficacy of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and T1-weighted Magnetic Resonance Imaging (MRI) …
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