Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 756 for “"Alzheimer's"”.
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Alzheimer's disease: support through design
Cognitive impairment caused by Alzheimer’s disease impacts over 5 million Americans. Cases of the disease are steadily increasing and are projected to reach 14 million Americans by 2050. Alzheimer’s disease gradually attacks mental, behavioral, and physical abilities, and the damage caused is …
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Phosphoproteomics analysis of Alzheimer's disease
Alzheimer's disease (AD) is a form of dementia characterized by the appearance of amyloid-[beta] plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Despite numerous clinical trials, a limited understanding of disease pathogenesis has prevented the development of …
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The Alzheimer's Disease Life Events Study
The Alzheimer's Disease Life Events study examines whether there is a relationship between life events and Alzheimer's disease (AD). The ADLE study uses a mixed methods approach to answer the central research question:Are life events a risk factor for Alzheimer's disease? The central research …
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Amyloid fibril formation in Alzheimer's disease
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1993.
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Dysregulated DJ1-Mediated Translation in Alzheimer's Disease
Alzheimer’s Disease (AD) is a form of dementia with aberrant synaptic transmission. It has been hypothesized that disrupted calcium signaling may cause the digression from healthy memory to mild cognitive impairment (MCI) and eventually AD; and the search for the source of calcium dyshomeostasis …
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The Role of Sulfatide in Alzheimer's Disease
Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta plaques, neurofibrillary tangles (NFT) and loss of cortical neurons that control memory and cognition. The cause of NFTs and Aβ plaques is not clear, though it is known that they are formed by enzymes which are …
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TARGETING REDOX IN AGING AND ALZHEIMER'S DISEASE
Aging, a major risk factor in Alzheimer's disease (AD), is associated with an increased free radical (ROS) generation, probably linked to mitochondrial dysfunction. While NADH is the ultimate electron donor for many redox reactions, glutathione (GSH) is the major ROS detoxifying redox buffer within …
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Sex-Differences in Early-Onset Alzheimer's Disease
Background: Prior research in Alzheimer’s disease (AD) suggests female sex is associated with increased disease risk and pathology burden, but this has not been examined in Early-onset AD (EOAD; onset <65). Using data from the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS), we examined …
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Modeling Alzheimer's Disease Using Cellular Reprogramming Technologies
… to neurons. Here I demonstrate the modeling of Alzheimer's disease (AD) using both iPS and iN cellular reprogramming technologies. These bioengineered human cell-based models of AD provide unique and invaluable tools for elucidating the mechanism of AD pathogenesis.
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Transcranial direct current stimulation in Alzheimer's disease
… direct current stimulation (tDCS) treatment of Alzheimer’s disease (AD) into a machine learning model of the disease to understand the long term impact of the treatment on disease progression over a decade. The three main contributions of this work are: Firstly, this work proposes the extension …
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The Role of Neuroinflammation in Alzheimer's Disease
… is believed to play a key role in Alzheimer’s disease, as evidenced by recent genome wide association studies highlighting several risk genes associated with the immune response. Misfolded and aggregated proteins bind to pattern recognising receptors on glial cells in the brain, …
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Homeostasis of metastable proteins in Alzheimer's disease
Alzheimer’s disease (AD) is the most common cause of dementia, affecting almost 40 million people worldwide, and it is predicted that this number will rise to nearly 150 million by 2050. It results not only in enormous distress for affected individuals and carers but also a substantial economic …
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Neuropsychological subgroups of dementia of the Alzheimer's type
… exist within the diagnosis of Dementia of the Alzheimer's Type (DAT). Specifically, the scores on the Cognitive Examination (CAMCOG) of the Cambridge Index of Mental Disorders in the Elderly for 51 DAT patients and 79 normal adults were analyzed via cluster analysis in an attempt to derive …
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Identification of Novel Fluid Biomarkers for Alzheimer's Disease
Clinicopathological studies suggest that Alzheimer's disease: AD) pathology begins to appear ~10-20 years before the resulting cognitive impairment draws medical attention. Biomarkers that can detect AD pathology in its early stages and predict dementia onset and progression would, therefore, be …
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Oxidative, inflammatory and vascular factors in Alzheimer's disease
… recent progress, the aetiopathogenesis of Alzheimer’s disease (AD) remains incompletely understood. The distinctive neuropathological features of AD, in particular the plaques and tangles, have been the particular focus of most aetiological theories. It is well accepted that AD is a …
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Stacked generalization for early diagnosis of Alzheimer's disease
<p>Alzheimer's disease (AD) is a neurological disorder characterized by nerve degeneration and neuronal death. The diagnosis of AD at an early stage is a major concern due to growing number of elderly people affected by the disease, as well as the lack of a standard diagnosis procedure available to …
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Modeling Alzheimer's Disease in Induced Pluripotent Stem Cells
<p>Alzheimer's disease (AD) is the most common cause of dementia worldwide, and is now the 5th leading cause of death in the United States. The pathologic hallmarks of AD include the deposition of extracellular plaques of aggregated amyloid-β (Aβ) and intracellular neurofibrillary tangles of tau …
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Examinations into the Calcium Hypothesis of Alzheimer's Disease
Alzheimer's disease (AD) is devastating to the patient, their family and friends, and represents a significant fiscal burden to our society. Currently available therapeutics provide only mild symptomatic relief and do not alter the course of the disease. Developing the next generation of disease …
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Characterisation of transgenic mouse models of Alzheimer's disease
… and pathological alterations associated with Alzheimer’s disease (AD). The 3xTg mouse is widely used as a research tool and carries mutations in the amyloid precursor protein (Swedish APP K670N/M671L), presenilin 1 (PS1M146V) and tau (TauP301L) which results in the development of pathological …
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