Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 69 for “"Alzheimer's"”.
-
A Comparison of the Frontal Variant of Alzheimer's Disease with Typical Alzheimer's Disease and Frontotemporal Dementia
A frontal variant of Alzheimer's Disease (FvAD) has been described in the literature in which prominent frontal lobe dysfunction accompanies typical temporal and parietal lobe dysfunction in the early stages of the illness. However, no study has investigated how executive deficits and …
-
ApoE Receptors in Alzheimer's and CNS Function
Alzheimer's disease (AD) is a currently incurable neurodegenerative disorder and the most common form of dementia over age 65. The predominant genetic risk factor for AD is the ε4 allele of apolipoprotein E (ApoE4). Other genes related to lipid metabolism and lipoprotein receptor signaling have …
-
Functional Connectivity of Entorhinal Cortex in Alzheimer's Disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by prominent memory impairment, executive dysfunction, language, construction, and visuospatial deficits. In AD, the accumulation of neurofibrillary tangles neuritic plaques, and other associated neuropathology, …
-
Utility of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Battery Total Score in the Progression of Alzheimer's Disease
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) created a neuropsychological battery that is both brief and sensitive to dementia (Morris et al., 1989). Chandler et al. (2005) put forth a method of calculating a Total Score for the CERAD along with normative data. The …
-
Changes in Brain Functional Connectivity Following Donepezil Treatment in Alzheimer's Disease
… of interest (ROIs) in eleven patients with mild Alzheimer's disease (AD) following treatment with the cholinesterase inhibitor, donepezil. The ROIs were selected on the basis of their association with cholinergic neurotransmission, AD neuropathology, and neurocognitive deficits in AD. These ROIs …
-
Familial Alzheimer's Disease Mutations in Presenilins Disrupt Endoplasmic Reticulum Calcium Leak
Alzheimer disease (AD) is the most common form of progressive dementia in adults over the age of 65 years. AD is a fatal brain disease and it currently affects about 27 million people worldwide. It is speculated that the number of people affected by AD will quadruple by 2050. The presence of …
-
Neuropathological significance of PLD1 in Alzheimer's disease and behavioral variant frontotemporal dementia
… in neurodysfunctional disorders including Alzheimer’s disease (AD). Our lab established, for the first time, an elevated PLD1 expression in crude synaptosomes from AD post-mortem brains and further demonstrated the effect of amyloidogenic insults amyloid-β (Aβ) and tau in wildtype mice, …
-
KLK6 modulates Αβ plaque accumulation in a mouse model of Alzheimer's disease
Η νόσος Alzheimer (AD) είναι μια νευροεκφυλιστική διαταραχή που χαρακτηρίζεται από προοδευτική γνωστική έκπτωση και εκτεταμένη νευρωνική δυσλειτουργία. Ένα χαρακτηριστικό γνώρισμα της AD είναι η υπερβολική συσσώρευση και εναπόθεση πεπτιδίων β-αμυλοειδούς (Aβ) στον εγκέφαλο, σχηματίζοντας πλάκες που …
-
Functional Connectivity of the Posterior Cingulate in Mild Cognitive Impairment and Alzheimer's Disease
… (MCI) has been implicated as an early stage of Alzheimer's disease (AD) by some, while others argue this is not necessarily the case. While controversy around this issue continues, it is undisputed that MCI is a risk factor for AD. Finding a biomarker of AD would lead to early intervention that …
-
Neuropsychological Predictors of Time to Conversion from Mild Cognitive Impairment to Alzheimer's Disease
… (MCI) is a risk state for the development of Alzheimer's disease (AD), though individual outcomes vary. Accurately predicting which MCI patients are likely to develop AD and how long they have until the onset of dementia could provide both patients and their families sufficient time to …
-
p53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's Disease
… diseases, and neurodegenerative diseases. Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by protein aggregates that contribute to disease pathology. Although p53 is known to aggregate, its propensity to aggregate in AD has never been assessed. Moreover, AD …
-
A life in song: A phenomenological perspective of a person with Alzheimer's disease
… how music is meaningful to one person with Alzheimer's disease who resides in a nursing home. Musical meaning and how music functioned in this woman's life both before and after the onset of Alzheimer's disease were explored. Data were collected by observation and participation in music …
-
Eyelid conditioning in mice reveals an interaction between stress and familial Alzheimer's disease
… then probed learning in two mouse models of Alzheimer Disease. Triple-transgenic (3xTg) animals expressing mutant Amyloid Precursor Protein, Presenilin-1 (PS1) and tau proteins were conditioned at ages ranging from 3-16 months. Mutants displayed more rapid learning compared to controls at all …
-
Involvement of the Sigma-1 Receptor in Neuronal Cell Death and Alzheimer's Disease
… in many neurodegenerative diseases such as Alzheimer’s Disease (AD). Recently, agonists of the Sig-1R have been found to be neuroprotective in AD and provide significant improvements in symptoms. The hallmarks of AD are aggregation of amyloid-β (Aβ) plaques and development of neurofibrillary …
-
Akt signal transduction dysfunction in the 3xTg-AD mouse model of Alzheimer's disease
Alzheimer’s disease (AD) is an incurable neurodegenerative disorder, accounting for over 60% of all cases of dementia. The primary risk factor for AD is age, however several genetic and environmental factors are also involved. The pathological characteristics of AD include extracellular deposition …
-
A Deep Learning Pipeline for Classifying Different Stages of Alzheimer's Disease from fMRI Data.
Abstract Alzheimer’s disease (AD) is an irreversible, progressive neurological disorder that causes memory and thinking skill loss. Many different methods and algorithms have been applied to extract patterns from neuroimaging data in order to distinguish different stages of AD. However, the …
-
Regulatory Role of ApoE and Apoer2 in Synaptic Activity: A New Insight into Alzheimer's Disease
… is the major genetic modifier of late-onset Alzheimer's disease (AD), the most common neurodegenerative disease in the elderly. By unknown mechanisms, ApoE4 isoform is strongly associated with a substantially earlier age of onset of AD. A synaptic ApoE receptor, Apoer2, activates Dab1 and Src …
-
Caring for a family member with Alzheimer's disease: the lived experiences of African American caregivers
Alzheimer’s disease is the most common type of dementia and is a significant health problem for the person with Alzheimer’s and for their caregiver. African Americans have at least double the prevalence of Alzheimer’s disease compared to European Americans. Additionally, African American caregivers …
-
Effect of Neurotoxic Insults in Knock Out Cell Lines for the Study of Alzheimer's Disease
Η νόσος του Alzheimer’s disease (AD) είναι μια προοδευτική νευροεκφυλιστική διαταραχή που χαρακτηρίζεται από έκπτωση των γνωστικών λειτουργιών, με τη συσσώρευση πλακών β-αμυλοειδούς (Aβ) και τα νευροϊνιδιακά πλέγματα να αποτελούν τα βασικά νευροπαθολογικά της χαρακτηριστικά. Αν και η υπόθεση του …
Page 1 of 4