Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 357 for “"Alzheimer"”.
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Therapeutische Möglichkeiten bei Alzheimer Demenz
Die Ursache der Alzheimer Demenz konnte bisher nicht geklärt werden. Eine kausale Therapie mit dem Ziel der Heilung ist somit z.Z. nicht <br>absehbar. Da auch durch verschiedene medikamentöse Therapien die Erkrankung letztendlich nicht aufgehalten werden kann, liegt ein weiterer Schwerpunkt der …
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A Comparison of the Frontal Variant of Alzheimer's Disease with Typical Alzheimer's Disease and Frontotemporal Dementia
A frontal variant of Alzheimer's Disease (FvAD) has been described in the literature in which prominent frontal lobe dysfunction accompanies typical temporal and parietal lobe dysfunction in the early stages of the illness. However, no study has investigated how executive deficits and …
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Measuring Dementia of the Alzheimer Type More Precisely
Alzheimer?s disease (AD) progressively impairs cognitive and functional abilities. Research on pharmacological treatment of AD is shifting to earlier forms of the disease, including preclinical stages. However, assessment methods traditionally used in clinical research may be inappropriate for …
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The role of transthyretin in Alzheimer disease pathology
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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ApoE Receptors in Alzheimer's and CNS Function
Alzheimer's disease (AD) is a currently incurable neurodegenerative disorder and the most common form of dementia over age 65. The predominant genetic risk factor for AD is the ε4 allele of apolipoprotein E (ApoE4). Other genes related to lipid metabolism and lipoprotein receptor signaling have …
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The role of mTOR signaling in Alzheimer s disease
The majority (>95%) of Alzheimer s disease (AD) cases are sporadic and of unknown causes. The single major risk factor for AD is aging and molecular changes that occur in the brain as a function of age may facilitate the development of AD. However, little is known as to how the aging process …
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Svipgerð stökkbreytingar í APP geninu sem verndar gegn Alzheimer sjúkdómi
Inngangur: Alzheimer sjúkdómur (AD) er taugahrörnunarsjúkdómur sem einkennist af síversnandi minnistapi auk annarra einkenna eins og skertri dómgreind og lélegri áttun. Meingerð sjúkdómsins birtist í amyloid skellum og taugatrefjaflækjum í heilavef einstaklinga. Uppsöfnun á beta amyloid (A) peptíði …
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Functional Connectivity of Entorhinal Cortex in Alzheimer's Disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by prominent memory impairment, executive dysfunction, language, construction, and visuospatial deficits. In AD, the accumulation of neurofibrillary tangles neuritic plaques, and other associated neuropathology, …
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Explicit/implicit memory performance and memory strategies in Alzheimer patients
… impaired. In contrast, results from studies with Alzheimer patients are mixed. This investigation re-explored these latter findings in a series of experiments, many that differed from those used in previous work, to find out how the performance of AD patients with different levels of functional …
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Empiric risk to first-degree relatives of Alzheimer disease patients
… evaluated for 1867 first-degree relatives of 338 Alzheimer Disease (AD) index cases and 1873 first-degree relativesof 351 non-cognitively impaired, non-demented elderly controls. A cumulative lifetime risk of 26.73 ± 4.42% for first-degree relatives of AD cases, while significantly higher than the …
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Utility of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Battery Total Score in the Progression of Alzheimer's Disease
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) created a neuropsychological battery that is both brief and sensitive to dementia (Morris et al., 1989). Chandler et al. (2005) put forth a method of calculating a Total Score for the CERAD along with normative data. The …
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Apolipoprotein E genotypes and Alzheimer disease in two black population groups
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Pathologische Veränderungen im Thalamus in einem Tiermodell für die Alzheimer-Krankheit
… pathologische Veränderungen, welche bei der Alzheimer-Erkrankung (AD) vorkommen. Die dafür verantwortlichen mutierten humanen Gene werden zur Erforschung in transgenen Mäusen exprimiert, mit der Folge, dass die AD-typischen Pathologien in den Mausgehirnen auftreten. Der Neuronenuntergang, der …
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Forvarnargildi reglubundinnar hreyfingar fyrr á lífsleiðinni gegn heilasjúkdómum á borð við Alzheimer
… þjást af heilabilun af einhverju tagi árið 2050. Alzheimer er taugahrörnunarsjúkdómur í miðtaugakerfi og er sjúkdómurinn algengasta orsök heilabilunar en rekja má 60-80% tilfella heilabilunnar til Alzheimer. Ýmsar aðferðir geta hjálpað til við að halda heilanum heilbrigðum og ásamt því dregið úr …
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Subtyping patients with Senile Dementia of the Alzheimer type using cluster analysis
… of patients with Senile Dementia of the Alzheimer Type (SDAT) could be identified using seven scales of the Cognitive Behavior Rating Scale (CBRS). Ward's method of cluster analysis was used to group 104 patients with a probable diagnosis of SDAT into subtypes.The following three clusters …
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Potentielle genetische Marker für die sporadische Form der Demenz vom Alzheimer-Typ
Bei 63 Patienten mit DAT (entsprechend den NINCDS-ADRDA- und ICD 10-Kriterien) und 162 nicht-dementen psychiatrischen Patienten (insgesamt 143 Frauen und 82 Männern, also 225 Probanden) wurden die Gene für Apolipoprotein E (Apo E), Apolipoprotein CI (Apo CI), α1-Antichymtrypsin (ACT), Low-density …
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