Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Alveologenesis"”.
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Ceramides as Therapeutic Targets in Bronchopulmonary Dysplasia
… the microvasculature and consequently disrupted alveologenesis. Premature infants are dependent on respiratory support, including oxygen supplementation and mechanical ventilation (MV), that are considered the main modifiable contributors to BPD. The mechanistic link between the injurious …
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THE ROLE OF ROMA IN MOUSE MAMMARY EPITHELIAL CELLS
… pregnancy. Roma/Zfp157 (Regulator Of Mammary Alveologenesis), has been shown by the Watson laboratory to be a critical regulator of alveolar lineage commitment in the mammary gland, with its depletion also resulting in accelerated alveologenesis during pregnancy coupled with DNA damage and …
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ENGINEERING STEM CELLS AND ORGANOIDS ON A CHIP FOR THE STUDY OF HUMAN HEALTH AND DISEASE
… immune responses in IBD. Finally, we present an alveologenesis-on-a-chip model that enables simulation of the fetal breathing movement-induced mechanical forces. The proposed system was then utilized to understand how forces, particularly those generated by fetal breathing movements, affect the …
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Studying the Effect of TBX4 Loss-of-Function on Postnatal Lung Development and How it Predisposes to Pulmonary Hypertension
… Wnt3a, Areg, Gdf2, and Bmper) relevant to lung alveologenesis, angiogenesis, and PH. This study contributes significant knowledge that clinicians can use to diagnose, classify, and treat patients with TBX4 mutations.
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Differentiation dynamics of mammary epithelial cells during normal and malignant development
… dysregulation of transcription factors driving alveologenesis. Our experimental approach has allowed us to further identify responses in the stromal and immune cell compartments during the early steps of tumourigenesis. Based on our data, we propose a model where transcriptional and epigenetic …
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Modeling Brk/PTK6 expression in the mammary epithelium.
… on cell death) similar to normal mammary alveologenesis when cultured on Matrigel, but are partially resistant to doxorubicin treatment, suggesting a context dependent component to Brk-mediated survival. HGF, EGF, or IGF treatment in cells that endogenously express Brk (non-transformed …
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Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
In the mammary gland, genetic circuits controlled by the hormones, estrogen, progesterone and prolactin (PRL), act in concert with pathways regulated by the epidermal growth factor (EGF) family to control the growth and morphogenesis of this tissue during puberty, pregnancy and lactation. However, …