Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Alveolar type II"”.
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Maturation of pluripotent stem cell-derived alveolar type II cells at air-liquid interface and response to environmental stimuli
Human pulmonary alveolar type II cells (AT2s) are facultative progenitors of the distal lung epithelium and secrete surfactant, a protein-lipid mixture that lowers alveolar surface tension and prevents alveolar collapse during expiration. AT2s exist at a physiological interface between inhaled air …
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Roles of MicroRNAs in Fetal Lung Development
Lung alveolar type II cells uniquely synthesize surfactant, a developmentally-regulated lipoprotein that is essential for breathing. Expression of the major surfactant protein, SP-A, in midgestation human fetal lung (HFL) is dramatically induced by cAMP. cAMP induction of SP-A expression is …
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
… condition characterized by diffuse alveolar damage, pulmonary edema, and severe hypoxemia, with limited therapeutic options. Increasing evidence identifies endothelial dysfunction and vascular barrier disruption as central drivers of ARDS pathogenesis, particularly in the context of …
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Investigating the impact of e-cigarettes on lung cells: a combined in vitro and computational study
… the effects of EC aerosol exposure on the alveolar epithelium using a combination of in silico modelling and in vitro experimentation. A computational model of aerosol transport and deposition in the human respiratory tract was applied to estimate regional dosimetry under direct-to-lung …
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Generation of induced progenitor-like (iPL) cells using interrupted reprogramming
… controlled expansion of the selected cell type, but results in the "de-differentiation" of the cells to a progenitor-like state while preserving the parental lineage commitment to generate a limited range of functional progeny. Lineage-specific iPL cells can be derived from distinct airway …
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The Role of Silicates in Interstitial Lung Disease
… Lung disease (ILD), produces disruption of alveolar walls with loss of functionality and accumulation of scar tissue. Asbestosis and silicosis are the ILD produced by the inhalation of asbestos fibers or silica particles respectively. An increase in prostacyclin release after exposing …
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The Role of Silicates in Interstitial Lung Disease
… Lung disease (ILD), produces disruption of alveolar walls with loss of functionality and accumulation of scar tissue. Asbestosis and silicosis are the ILD produced by the inhalation of asbestos fibers or silica particles respectively. An increase in prostacyclin release after exposing …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… and progression remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been identified as key cells of origin of LUAD, little progress has been made in understanding the precise sequence of events that transform single AT2 cells into …
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Cell Fate Decisions in the Developing Lung
… for conducting air towards the alveoli, and an alveolar region where gas exchange takes place (Herriges and Morrisey, 2014). During embryogenesis, the airways are first laid down through an iterative process of branching morphogenesis, which terminates at the alveoli. Throughout gestation the …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
… is a chronic disease that is characterized by alveolar destruction due to increasing extracellular matrix deposition that leads to poor lung compliance, impaired gas exchange, and ultimately respiratory failure. Repetitive alveolar epithelial injury is a central process to the underlying …