Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Alveolar macrophages"”.
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Kinetics and mechanisms of accumulation for liposomal ciprofloxacin into rat alveolar macrophages
… liposomal ciprofloxacin (Lipo-CPFX) into the rat alveolar macrophage NR8383 cells were studied in vitro, in comparison to unformulated ciprofloxacin (CPFX). Upon incubation with CPFX or Lipo-CPFX, cellular drug accumulation was determined from the cell lysates or efflux was from the extracellular …
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Transport and utilization of arginine and arginine-containing peptides by rat alveolar macrophages
Purpose. To demonstrate that alveolar macrophages (AM) from rats exhibit pepT1-like transporter for the uptake of small arginine-containing peptides (ACPs) and utilized these peptides as direct substrates for nitric oxide (NO) production.;Method. A HPLC assay was developed for quantitative …
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Influence of Rhodococcus Equi on the Respiratory Burst of Resident Alveolar Macrophages From Horses
… Rhodococcus equi are phagocytosed by equine alveolar macrophages but are ineffectively killed. The respiratory burst of equine neutrophils is obtunded by R. equi. If the bacteria similarly influence equine alveolar macrophages, that could partially explain its facultative intracellular …
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The effect of envelope glycoprotein gI on the replication of pseudorabies virus in porcine alveolar macrophages
… lungs are a main site of viral replication and alveolar macrophages (PAM) are productively infected. Programs for the eradication of PrV are currently underway in the United States and Europe. Most of the PrV vaccines used in the programs are genetically engineered for deletion of the envelope …
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MFSD7C is an ATP Transporter that Supports Bacterial Killing by Alveolar Macrophages in a Lipid-Rich Microenvironment
… infections. We now show that Mfsd7c-deficient alveolar macrophages in mice have an impaired ability to counter infection. This is demonstrated to be due to their altered metabolic state, characterized by heightened glycolysis and reduced lipid oxidation. When Mfsd7c-deficient alveolar …
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Exosomal Communication By Metastatic Osteosarcoma Cells Modulates Alveolar Macrophages to An M2 Tumor-Promoting Phenotype and Inhibits Tumoricidal Functions
… of tumor promoting immunosuppressive M2<em> </em>macrophages in the metastases and poor patient survival. By contrast, M1<em></em>macrophage predominance correlates with longer survival. M2 macrophages can be induced by various stimuli in the tumor microenvironment, including exosomes, which are …
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The Production of Nitric Oxide By Murine Peritoneal and Alveolar Macrophages in Response to Candida Albicans Yeast and Hyphae
… enhances virulence. Murine peritoneal (PM⏀) and alveolar macrophages (AM⏀) produce a variety of cytokines as well as nitric oxide (NO), a short lived radical gas, in response to C. albicans. PM⏀ and AM⏀ were harvested and stimulated with C. albicans yeast or hyphae alone or a combination of …
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Effect of penicillin G on the reproduction of Salmonella cholerasuis in the presence and absence of porcine alveolar macrophages in a pharmacodynamic model
… in the presence and absence of porcine alveolar macrophage (PAM). The results of an intra-arterial penicillin G dosing trial completed in swine indicated that the disappearance of penicillin from plasma could be accurately described by an open two-compartment model. A dynamic in vitro …
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Analysing M. avium-macrophage interactions and establishing a long-term infection in a novel and realistic model of lung alveolar macrophages, Max Planck Institute Cells
… the host involve a specialised group of tissue macrophages that reside in the lung alveolar space called alveolar macrophages (AM). They have specialised functions that are suitable for recognition of foreign invaders and the ability to tackle these threats though means of a robust immune …
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Analysing M. abscessus-macrophage interactions and investigating treatments for M. abscessus and S. aureus intracellular bacterial infections, using a continuously growing, primary cell model of lung alveolar macrophages
… amongst them. During pulmonary infection, alveolar macrophages (AMs), as sentinel immune cells of the airways, are key cells for the recognition of these invaders, and they are central to activating and orchestrating the host immune responses aimed at eliminating these pathogens. …
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Effects of Mannan Oligosaccharide on Immune Function and Disease Resistance in Pigs
Key words: Alveolar macrophages and cytokine secretion; disease resistance; immunomodulation; mannan oligosaccharide; pigs; PRRSV.
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A guinea pig model of human respiratory syncytial virus lung infection
… RSV antigens were identified within alveolar macrophages up to day 60 and RSV genomic RNA was identified on day 125. In conclusion, human RSV produced a self-limited acute bronchiolitis in juvenile guinea pigs, with evidence of subsequent persistent infection of alveolar macrophages. …
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Virulence and pathogenic mechanisms of <i>Legionella pneumophila</i>
… forms multiplied within guinea pig alveolar macrophages maintained in tissue culture over 48 hours and phagosome lysosome fusion was not inhibited in these macrophages. Avirulent strains did not multiply but those produced by passage on supplemented Mueller Hinton agar (MHIH) …
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Transcriptomic profiling of macrophage polarization
Macrophages perform a wide variety of crucial, and sometimes contradictory, functions. While “pro-inflammatory” activities like fighting off infections and “anti-inflammatory” activities like wound-healing traditionally have been attributed to M1 and M2 macrophage subsets, studies of macrophages in …
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Rac1 signaling regulates platelet-dependent inflammation abdominal sepsis
… in septic lung injury via activation of alveolar macrophages leading to local secretion of CXCL2. Thus, our novel data not only elucidates complex mechanisms regulating pulmonary neutrophil trafficking in sepsis but also suggest that targeting Rac1 signaling and platelet-derived CCL5 …
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Etude du rôle des macrophages interstitiels dans l'allergie des voies respiratoires
… is tightly controlled by lung interstitial macrophages, a cell population that remains largely uncharacterized. Interstitial macrophages could be distinguished from alveolar macrophages by their unique capacity to inhibit lung dendritic cell maturation and migration upon LPS stimulation, …
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Studies on the interaction between porcine reproductive and respiratory syndrome virus and its natural host cell
… global disease of swine. PRRSV infects their alveolar macrophages (AMΦ) resulting in an interstitial pneumonia. The ability of PRRSV to modulate the production of interferon (IFN)a and tumor necrosis factor (TNF)a by affected AMΦ is implicated in the virus’s pathogenesis. In this regard, …
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Suppression of NK cell-mediated cytotoxicity and immunoenhancement of CD40 ligand against porcine reproductive and respiratory syndrome virus
… a restricted host and cell tropism, with porcine alveolar macrophages (PAMs) as important host cells. In 2006, most swine farms in China experienced a “high fever disease of swine” caused by new PRRSV variants, which led to great economic losses to Chinese swine industry, bring new challenge to …
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Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
… smoking/nicotine enhances HIV replication in alveolar macrophages, microglia, and T cells. However, the mechanism by which smoking or nicotine increases HIV replication is largely unknown. As an exception, a report suggests that iron and oxidative stress are possible mechanisms of enhanced …
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