Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Alveolar macrophage"”.
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Enhancement of Porcine Alveolar Macrophage Response to Respiratory Pathogens by Dietary Supplementation of Long-chain PUFA.
North Carolina State University Theses Animal Science.
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Kinetics and mechanisms of accumulation for liposomal ciprofloxacin into rat alveolar macrophages
… liposomal ciprofloxacin (Lipo-CPFX) into the rat alveolar macrophage NR8383 cells were studied in vitro, in comparison to unformulated ciprofloxacin (CPFX). Upon incubation with CPFX or Lipo-CPFX, cellular drug accumulation was determined from the cell lysates or efflux was from the extracellular …
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Macrophages in vitro as a predictive model in polymer toxicology
… by assessment of inflammatory cell profile (alveolar macrophage (AM), polymorphonuclear neutrophil (PMN)) of broncho-alveolar lavage fluid (BAL) 24hrs after a single instillation of either 0.5 mg or 2 mg polymer in Sprague Dawley rats. Pro-inflammatory Minusil particles and non-inflammatory …
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Sources of Pulmonary GM-CSF and Its Roles in Myeloid Cell Homeostasis
Granulocyte-macrophage colony-stimulating factor (GM-CSF, encoded by Csf2) is a pro-inflammatory cytokine essential for the development, maintenance, and maturation of specific myeloid cells. In the lung, GM-CSF serves as a critical local environmental cue that defines the identity of …
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Development of an inhaled liposomal-loaded azithromycin formulation for the treatment of chronic respiratory infection
… from a lipopolysaccharide stimulated murine alveolar macrophage cell line in vitro. Finally, the adjustment of protectant sugar to a mixture of trehalose and dextran offered further improvements in glass transition temperature and water content. The results of this study support the potential …
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The role of lipid laden macrophages in airways disease
… Gastro-Oesophageal Reflux (GOR). Lipid laden macrophages (LLM) in the airway have previously been reported indicative of aspiration secondary to GOR. We hypothesised that lipid droplets from undigested or partially digested food may be aspirated into the airway and accumulate in scavenging …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… characterised by excessive inflammation in the alveolar compartment resulting in oedema of the airspaces due to loss of integrity in the alveolar epithelial-endothelial barrier. ARDS is associated with high mortality rates and there are currently no effective pharmacological therapies available. …
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Modulation of thiols and pulmonary immune responses due to diesel exhaust particle (DEP) exposure
… protein, and albumin content in lavage fluid. Alveolar macrophage (AM) from DEP-exposed rats showed a time-dependent increase in intracellular cysteine (CYSH) and glutathione (GSH). In lymph node cells (LNC, the intracellular GSH increased significantly at 24 hours, and declined at 72 hours …
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Transcriptomic profiling of macrophage polarization
Macrophages perform a wide variety of crucial, and sometimes contradictory, functions. While “pro-inflammatory” activities like fighting off infections and “anti-inflammatory” activities like wound-healing traditionally have been attributed to M1 and M2 macrophage subsets, studies of macrophages in …
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Characterization of the composition and toxicity of particulate matter emissions from advanced heavy-duty natural gas engines
… three different assays a) DHBA b) DTT and c) alveolar macrophage ROS assay.;Results of the gas phase chemical speciation results reported all carbonyl, PAH and VOC emissions close to levels found in background or below the detection limits of the analytical method. Results of elemental …
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Soy Isoflavones Mediate Radioprotection Of Normal Lung Tissue By Modulating The Radiation-Induced Inflammatory Response
… inflammatory processes involving macrophages, neutrophils, and myeloid-derived suppressor cells. </p> <p>The major findings of this work suggest that soy isoflavones can inhibit inflammatory responses triggered by a single dose of thoracic irradiation in the lung, including NF-κB …
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Host response of lung cells to virulent Bacillus anthracis
… paradigm in anthrax literature labels the alveolar macrophage (MØ) as the primary cell utilized by spores as a safe site for germination and transport to host lymphatics. This study was the first to report that, unlike their murine counterparts, human alveolar MØs mediate the killing of the …
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Effect of penicillin G on the reproduction of Salmonella cholerasuis in the presence and absence of porcine alveolar macrophages in a pharmacodynamic model
… in the presence and absence of porcine alveolar macrophage (PAM). The results of an intra-arterial penicillin G dosing trial completed in swine indicated that the disappearance of penicillin from plasma could be accurately described by an open two-compartment model. A dynamic in vitro …
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Novel approaches to enhance the protective immune responses of vaccines against Porcine Reproductive and Respiratory Syndrome Virus
… expressed on the cell membrane of porcine alveolar macrophage (PAMs) after recombinant MLVs infection in vitro. Subsequently, pigs vaccinated with cytokine-expressing recombinant PRRSV MLVs had an improved antiviral response of cytotoxic lymphocytes including natural killer (NK) cells and T …
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Glycan polymeric prodrugs against pulmonary intracellular alveolar infections
… mannose glycopolymer prodrugs to target the macrophage mannose receptor on alveolar macrophage cells would eradicate or minimize bacterial replication and allow for better protection against intracellular infections. We demonstrated that mannose polymeric prodrug systems provided …
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Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii
… We recruited ten lung samples via bronchoalveolar lavage from healthy individuals to be used as a control group for the lung cancer patients study. Samples were tested with nested PCR targeting five T. gondii specific markers (B1, SAG1, SAG2 3′, SAG2 5′ and SAG3) and only one sample was …
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Investigating the role of the Dendritic Cell Immunoactivating Receptor in the Immune Response during Pneumocystis murina
… Flow cytometry analysis showed an increase in alveolar macrophage, dendritic cells, inflammatory monocytes, eosinophils and T cell recruitment to the lung. While ELISA showed increased levels of IL-1β and IFN-γ at 48 hours, and later on in infection IL-1β and IL-12p40 levels were also elevated. …
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Effect of atorvastatin on asthma control and airway inflammation: a randomised controlled trial
… 8 weeks, the mean absolute and relative sputum macrophage count was significantly reduced after atorvastatin compared to placebo [mean absolute difference -44.9x104 cells, 95% CI -80.1 to -9.7, p=0.029]. There was a reciprocal increase in the relative proportion of sputum neutrophils [mean …
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The Effects of Chronic Ethanol Ingestion and Smoke Exposure on Anti-Pneumococcal Host Defenses
… rats that were sham-exposed exhibited suppressed alveolar macrophage phagocytosis of pneumococci as well as diminished opsonization of the bacteria within their lungs. It is uncertain if smoke exposure increased macrophage phagocytosis due to technical problems with the assay, but concurrent smoke …
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