Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Alveolar epithelium"”.
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Accelerated Maturation of Fetal Alveolar Epithelium in New Zealand Rabbits After Single Maternal Injections of Solu-Medro
… infants as a result of an immature pulmonary epithelium. In utero fetal injections of glucocorticoids accelerate the maturation of the alveolar epithelium. Recent studies indicate that maternal injections of certain glucocorticoids may also be effective. To examine this further, pregnant New …
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YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION
Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery from these insults to rebuild the epithelial barrier and restore pulmonary functions. Here, we show that …
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Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury
… cytokines and chemokines production from alveolar epithelial and endothelial cells and III) leukocyte migration from blood circulation into alveoli. Currently, there is no FDA approved pharmacological treatment available except the supportive mechanical ventilation therapy. Numerous …
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Role of Cuzd1 in mammary gland development and tumorigenesis
… of estrogen regulation in the mouse mammary epithelium. Mice lacking Cuzd1 exhibited a striking impairment in steroid-induced proliferation of mammary ductal and alveolar epithelium. Our study revealed that Cuzd1 controls the production of a subset of EGF family growth factors, neuregulin-1, …
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The Genome-Wide Roles of The Lung Lineage Transcription Factor Nkx2-1 In The Regulation of Opposing Cell Fates In Vivo
… 2-1 (NKX2-1) is expressed throughout the lung epithelium during development and was thought to be lost in the extraordinarily thin cell type required for gas exchange– the alveolar type 1 (AT1) cell. Complementing precise genetic knockouts with cell type-specific ChIP-seq, ATAC-seq, and …
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Investigating the impact of e-cigarettes on lung cells: a combined in vitro and computational study
… the effects of EC aerosol exposure on the alveolar epithelium using a combination of in silico modelling and in vitro experimentation. A computational model of aerosol transport and deposition in the human respiratory tract was applied to estimate regional dosimetry under direct-to-lung …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… to the structure they support – the endothelium, epithelium and interstitium. We also identified two subpopulations of neonatal lung myofibroblasts – ductal myofibroblasts that envelop alveolar ducts that persist into adulthood and alveolar myofibroblasts that undergo developmental apoptosis. …
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A study of the causes and consequences of SFTPC mistrafficking in alveolar type 2 cells using novel organoid models
… IPF is triggered by repeated microinjury to the alveolar epithelium and dysfunction of alveolar type 2 (AT2) cells, which in health produce pulmonary surfactant and act as progenitor cells to enable epithelial repair. AT2 cell dysfunction results in failed alveolar re-epithelisation and …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… and progression remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been identified as key cells of origin of LUAD, little progress has been made in understanding the precise sequence of events that transform single AT2 cells into …
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Maturation of pluripotent stem cell-derived alveolar type II cells at air-liquid interface and response to environmental stimuli
Human pulmonary alveolar type II cells (AT2s) are facultative progenitors of the distal lung epithelium and secrete surfactant, a protein-lipid mixture that lowers alveolar surface tension and prevents alveolar collapse during expiration. AT2s exist at a physiological interface between inhaled air …
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Stem and Progenitor Cells in Homeostatic Maintenance and Perturbation of the Pulmonary Epithelium
… from a normal pseudostratified airway epithelium to lung squamous cell carcinoma in situ are well documented. However, the contribution of mutated tissue stem or progenitor cells to this process are poorly understood at the level of clonal resolution. Secretory cells are known …
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Compartmental responses of the respiratory tract to Staphylococcus aureus
… The cell line RPMI 2650 (representative of nasal epithelium) and the cell line A549 (representative of type II alveolar epithelium) were used to establish the cytokine response to stimulation with TLR ligands and to demonstrate the presence of tollip protein by immunocytochemistry and enzymelinked …
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Verstärkung der Zelladhärenz und Induktion des Zell-Spreading - eine neue Funktion von RAGE, einem hoch selektiven Differenzierungsmarker humaner Alveolar-Typ 1-Zellen
… provided the selective localization of RAGE on alveolar epithelial type I cells as demonstrated in frozen lung sections as well as in in vitro cultivated lung cells. RAGE could be identified as a novel, highly specific marker for the thin, expanded AT I cell, which form part of the …