Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Alveolar Epithelial Cells"”.
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RAC1-Mediated Actin Cytoskeleton Remodeling and Monolayer Barrier Properties of Stretched Alveolar Epithelial Cells
… regional lung volumes resulting in excessive alveolar epithelial cell (AEC) stretch due to basement membrane deformation and reduced barrier function. AECs maintain integrity of the blood-gas barrier with gasket like intercellular tight junctions (TJ) which are anchored internally to the actin …
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Compartmental responses of the respiratory tract to Staphylococcus aureus
… looking at its effects on human primary nasal epithelial cells and their response to TLR ligands. The respiratory tract itself seems to pose a contradiction given by the clinical observation that its upper portion (nasal compartment) allows the growth of bacteria, acting like a reservoir, …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
… is a chronic disease that is characterized by alveolar destruction due to increasing extracellular matrix deposition that leads to poor lung compliance, impaired gas exchange, and ultimately respiratory failure. Repetitive alveolar epithelial injury is a central process to the underlying …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
… receptor in various cell types, including alveolar macrophages. IL-6 is elevated in mouse models and humans with chronic lung disease, suggesting a potential role in disease progression. Furthermore, chronic elevation of adenosine in the lungs of adenosine deaminase deficient …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
… induces senescence in lung fibroblasts and alveolar epithelial cells. 1,2,3,4-diexpoxybutane, or diepoxybutane (DEB), is the most reactive metabolite of 1,3-butadiene, an important hazardous air pollutant and potent genotoxic agent found in cigarette smoke. In this study we examined the …
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Influenza A Virus Induced Programmed Cell Death
… important for IAV pathogenesis. These are (1) alveolar unit cells and (2) cells of the conducting airways, primarily those of the bronchi and bronchioles. Alveolar unit cells, or pneumocytes, chiefly comprise type I and type II alveolar epithelial cells, and are involved in gas exchange and …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… and mechanism of CsA against DENV-2 in A549 lung alveolar epithelial cells, Huh7 human hepatoma cells, and THP-1 monocyte-derived macrophages. We demonstrated that CsA effectively inhibits DENV-2 in all three cell types. Notably, the antiviral activity of CsA against DENV-2 is independent of its …
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Development of an inhalable nanomedicine for lung cancer
… connective tissue and adenocarcinoma human alveolar epithelial cells. RALA peptide was highly efficient at condensing and delivering pEGFP-N1 into cells and resulted in gene expression in the selected cell lines. Thereafter, inhalable RALA/pEGFP-N1 NPs were produced via spray drying using a …
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Development and Utilization of a Bioengineered 3D Human Lung Model to Study Pathogenesis of Lung Disease
… that whole AC pediatric lung scaffolds and cells isolated from discarded human lungs can be used to bioengineer whole-organ constructs with functional characteristics similar to native human lungs. Small-scale human lung constructs can also be developed and used as models for repetitive …
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ENGINEERING STEM CELLS AND ORGANOIDS ON A CHIP FOR THE STUDY OF HUMAN HEALTH AND DISEASE
… patient-derived induced pluripotent stem cells to recreate fat and retina tissues. These model systems were used to investigate key pathological features of white adipose tissue and age-related macular degeneration in patients and showed their potential to revolutionize drug testing and …
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Aspergillosis: interactions of Aspergillus fumigatus andHuman Airway Cells
… possesses immusuppresive activity affecting cells of immune system. This research shows that human adenocarcinoma alveolar epithelial cells (A549) are highly susceptible to gliotoxin- induced cell death. Wild type strains of A. fumigatus cause death in these cells whereas mutant strains …
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Roles of MicroRNAs in Fetal Lung Development
Lung alveolar type II cells uniquely synthesize surfactant, a developmentally-regulated lipoprotein that is essential for breathing. Expression of the major surfactant protein, SP-A, in midgestation human fetal lung (HFL) is dramatically induced by cAMP. cAMP induction of SP-A expression is …
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Pengaruh ekstrak etanol daun sirsak (Annona muricata L.) terhadap gambaran histologi kelenjar mammae mencit (Mus musculus) yang di induksi 7,12-dimentilbenz(a)antrasen (DMBA) secara in vivo
… which have cytotoxic properties against cancer cells, including breadt cancer. The active ingredient is able to control mitochondria (producing energy organ cells) required for cancer cells to grow. This study aimed to determine the effect of ethanol extract of leaves of soursop (Annona muricata …
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Enteral docosahexaenoic acid supplementation to attenuate inflammation in the preterm infant
… in preterm infants and in human type II alveolar epithelial cells (AEC). The N3RO randomised controlled trial (RCT) provided the opportunity to carry out a single-centre nested study to examine the effect of supplemental DHA in preterm infants on pro-inflammatory and regulatory biomarkers …
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Investigating the impact of e-cigarettes on lung cells: a combined in vitro and computational study
… the effects of EC aerosol exposure on the alveolar epithelium using a combination of in silico modelling and in vitro experimentation. A computational model of aerosol transport and deposition in the human respiratory tract was applied to estimate regional dosimetry under direct-to-lung …