Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Alternative substrate"”.
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Defined Dimensional Changes in Purine Analogues
… or quinazolines, were found to be active substrates for and alternative-substrate inhibitors of xanthine oxidase. In each case, the product of enzymatic oxidation has been isolated and compared with the same material synthesized chemically. These oxidation products have been identified as …
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Porous Gallium Nitride Generated by Electroless Etching: Morphology, Optical Properties, and Sensing Applications
… GaN, GaN films must be grown heteroepitaxially. Substrates for GaN growth are not ideal, and introduce strain and defects. Porous GaN has been studied as an alternative substrate for high-quality epitaxial GaN film growth, and has shown modest improvement in crystal quality over conventional …
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Charakterisierung der reduktiven Aktivitäten der CO-Dehydrogenasen aus Oligotropha carboxidovorans und Streptomyces thermoautotrophicus
… die aerobe CO-Dehydrogenase in der Lage ist, alternative Substrate wie Azid, Nitrit und Nitrat zu reduzieren. CO-Dehydrogenase aus Oligotropha carboxidovorans und Streptomyces thermoautotrophicus führen die Reduktionsreaktion wie folgt durch: Azid wird zu Ammonium und molekularem Distickstoff …
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Potential Silvicultural Effects on Bald Eagle Nesting Substrate and Economic Yields at a Navy Installation in the Chesapeake Bay: An Approach Using the Forest Vegetation Simulator and Mahalanobis Distance
… used to define and classify preferred nesting substrate. Silviculture was simulated using the Forest Vegetation Simulator (FVS) to assess forest nesting substrate, economic yields and the tradeoffs between these two objectives. An alternative substrate model based on cumulative distribution …
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Epifaunal assemblage of a newly established oyster reef with two substrates
… mined shell material to the typical oyster shell substrate used in artificial reef projects as an alternative substrate and cultch material. Half of the reef's veneer was the fresh oyster shell and the other half was mined material. Experimental trays were deployed on top of the sediment along the …
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Engineering fluorescent imaging platforms to characterise molecular interactions with HIV-1 capsid
… on a glass surface as the biorecognition substrate for sensitive single-molecule binding studies. The biosensor was assessed in its ability to measure binding affinity, stoichiometry and kinetics using known capsid-binding cofactors as part of its validation process. Biosensor measurements …
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Engineering TEV Protease Specificity: An Exploration of Machine Learning and High-Throughput Experimentation for Protein Design
… have failed to engineer specificity in cleaving alternative substrates, rendering them useless. In this thesis, we aim to engineer TEV (tobacco etch virus) protease, a highly sequence-specific protease, to cleave alternative substrates. We incorporate novel high-throughput assays and powerful …
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Technological Development of Chemical Sensors for Healthcare and Safety Applications
… (PDMS), paper and cotton threads. The choice of substrate materials hassled to functionalities that are suitable for a wide spectrum of applications, which has been previously limited by the use of conventional substrates such as glass and silicon. There are technical challenges in terms of …
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The evolution and diversity of noncanonical microbial nitrogen metabolisms
… have been shown to reduce off-target nitrogenous substrates, including HCN. Using ancestral sequence reconstruction, I compare the sequence space of predicted ancestral and extant nitrogenase substrate channels. The results indicate that the predicted highest-likelihood ancestral states for key …
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DESIGN, SYNTHESIS, AND OPTIMIZATION OF SMALL-MOLECULE CD4 MIMETICS AS HIV-1 ENTRY INHIBITORS AND SYNTHETIC EFFORTS TOWARD THE TOTAL SYNTHESIS OF NAHUOIC ACID Cii
… a sustainable and environmentally benign alternative without loss of efficiency. The cis-decalin fragment synthesis was further streamlined through PtO2-catalyzed selective hydrogenation, eliminating redundant steps and improving overall step economy. The two fragments were united by a …
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Catalytic promiscuity of two plant P450 enzymes: CYP725A4 from Taxus cuspidata and CYP71B102 from Isatis Tinctoria
… production of indirubin and indigo from a common substrate, but it also decreases the yield of paclitaxel in both plants and heterologous hosts, respectively. In this thesis, the catalytic promiscuity of CYP725A4 from Taxus cuspidata and CYP71B102 from Isatis tinctoria were investigated. CYP725A4 …
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Mechanistic studies to determine the catalytic roles of active site residues in phosphite dehydrogenase
… that Arg301 plays an important role in substrate binding. The crystal structures of the Arg301Ala and Arg301Lys mutants of PTDH have been solved, and they are consistent with these proposed roles. In proteins, methionine residues are most commonly associated with hydrophobic interactions …
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Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery
… to L-arginine, suggests it might act as an alternative substrate for nNOS in this tissue. 11.Isoform-selective inhibitors of NOS are of great interest, both as investigational tools and potential therapeutic agents. Two nNOS-specific inhibitors have recently been identified: …
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The use of hair detect (and monitor) chronic hyperglycaemia
… it is likely that hair can be used as an alternative substrate for monitoring chronic hyperglycaemia. Subjects and Methods: Scalp hair and a blood samples (for HbA1c) were collected from 46 diabetic and 46 healthy control subjects. There were 26 diabetic adults (30-70 years), recruited …
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Viral HSV1-TK gene, radiolabeled FIAU, and ganciclovir: combined gene targeted radiotherapy and suicide gene therapy for prostate cancer
… (FIAU) is an alternative substrate of the HSV1-TK enzyme. The iodine atom of FIAU can be substituted with radioactive iodine, for example; [123I]-iodine, and thereby utilised for the delivery of ionising radiation into tumour cells expressing the viral tk gene. …
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Energy metabolism in Arbidopsis thaliana: TCA cycle evolution, amino acids degradation and alternative pathways
… phosphorylation (OXPHOS) system and its alternatives pathways under energy limitation remains elusive. Thus, this thesis, which is focused on the function of respiration within the context of the role of the TCA cycle as well as the function of alternative electron donors to the mETC, …
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Investigating red pigment production by Penicillium purpurogenum DSM 62866
… consumer-driven move toward natural colourant alternatives in food, cosmetic and nutraceutical products. The majority of natural pigments currently in use are obtained from sources such as insects and plants, including fruit and vegetables. These sources are inherently affected by natural …
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Investigation of alternative carbon sources for the biological treatment of synthetic sulphate-laden water and mine impacted water in a linear flow channel reactor
… sulphate reduction (BSR) offers a sustainable alternative for sulphate removal and is applicable to partially treated AMD as well as circum- neutral, mine-impacted water. Coupled with partial sulphide oxidation, it also has the potential to convert sulphate to elemental sulphur, touching on …