Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 247 for “"Alternative splicing"”.
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Regulation of Human Telomerase Alternative Splicing
… subunit of human telomerase (hTERT) may be alternatively spliced into 22 different isoforms. Only a small fraction of hTERT transcripts are spliced into the full length isoform, the form capable of being translated into function hTERT with reverse transcriptase activity. If telomerase …
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Aberrant and Alternative Splicing of von Willebrand Factor
… are thought to disrupt the process of VWF splicing leading to VWD; however, this primarily acknowledges canonical splice site mutations, where the nucleotides are most integral and highly conserved to accomplish proper splicing. We hypothesized that pathologic splicing of VWF is likely an …
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iPLA2β, ALTERNATIVE SPLICING AND APOPTOSIS OF PANCREATIC ISLETS
… are bioactive lipids that can promote splicing of apoptosis-related genes, including caspase 9 and BCL-x. A recent study demonstrated that expression of neutral sphingomyelinase (NSMase), an enzyme that hydrolyzes sphingomyelins to generate ceramide, is regulated by Group VIA …
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Nova Regulation of Alternative Splicing in the CNS
… here confirms that Nova-1 acts as a regulator of alternative splicing in vivo. In addition to the known target Nova-dependent splicing regulation, exon 3A of glycine receptor α2 subunit (GlyRα2), two new targets are identified, which are the alternative exon, E9 in the inhibitory neurotransmitter …
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Genomic Profiling of Alternative splicing in liver cancer
… provides ability to estimate expression of alternative splicing isoforms of a single gene. The expression of diverse isoforms with alternative splicing has been also implicated in development of cancer. In the present study, RNA-sequencing of 61 HCCs was performed to reveal the effect of …
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Study of alternative splicing events associated with hyperalgesia
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Can changes in SR protein acetylation affect alternative splicing?
… of the proteome. One such process is called alternative splicing. Splicing is the removal of introns from a pre-mRNA sequence and the remaining pre-mRNA sequences, called exons, are combined. Alternative splicing modifies the intron-exon combination, and can form novel products from the …
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The Regulation of the Alternative Splicing of Caspase 9
… 9b, are derived from the caspase 9 gene by alternative splicing. This study demonstrates that the alternative splicing of caspase 9 is dysregulated in a large percentage of non-small cell lung cancer (NSCLC) tumors of the adenocarcinoma type. Furthermore, modulation of the levels of splice …
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Germline variants associated with alternative splicing in colonic mucosa
… studies have highlighted the contribution of alternative splicing to cancer progression, and have linked variants altering splicing patterns to predisposition to other complex traits. This study has analysed RNA-seq from 221 samples of colonic mucosa (the precise tissue of origin of CRC) from …
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Regulation of alternative splicing and its connections to cancer
… separate pieces of work pertaining to pre-mRNA splicing in mammalian cells. The first piece, as the main research project of the thesis, consists of two related parts. The first part identified the regulators of the alternative splicing of the PKM gene in cancer cells while the second part …
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Studies of exon scrambling and mutually exclusive alternative splicing
… of this thesis work were to study two special alternative splicing events: exon scrambling at the RNA splicing level and mutually exclusive alternative splicing (MEAS) by computational and experimental methods. Chapter 1 presents work on the study of exon scrambling, in which exons are spliced …
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Regulation of alternative splicing in the rat fibronectin gene
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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The Effect of Low Temperature on Alternative Splicing in Barley
… It is now clear that genome-wide changes in alternative splicing (AS) also occur in Arabidopsis during the cold-response and many of the genes which undergo cold-induced AS have been linked to roles in either the regulation of the cold-response or regulation of AS. Mutations in splicing …
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Alternative splicing in the regulation of the barley circadian clock
… of orphan snoRNAs in the regulation of alternative splicing (AS) in Arabidopsis. This project was very attractive but ran into serious and unforeseen problems with the genetic background of mutants used in the project. Despite deciding to terminate the project, it gave me more experience …
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Alternative Splicing Expands Spatiotemporal Expression Complexity of Arthropod N -Cadherin
… of transcriptomes. Both gene duplication and alternative splicing have been proposed as a means to expand transcriptomes. Although gene duplication expands genomics, the small number of protein-coding genes in metazoan genomes is insufficient to account for their cellular diversity within …
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Alternative splicing and single-cell RNA-sequencing: a feasibility assessment
… the fundamental molecular biology process of how alternative splicing is regulated within cells. However, scRNA-seq is a relatively new technology, and at the start of my PhD it was not clear whether existing bioinformatics approaches would enable accurate splicing analyses. In my PhD I consider …
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CELF1, PTBP1, and RBFOX2-mediated alternative splicing regulation in cardiovascular diseases
Alternative splicing (AS) is dysregulated in Type 1 diabetic (T1D) and hypoplastic left heart syndrome (HLHS) patient hearts but the mechanisms responsible are unclear. Here, we provide evidence that in these patient’s hearts that dysregulation of the RNA binding proteins (RBPs) CELF1, PTBP1, and …
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INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS
Alternative splicing (AS) is vital for proteome flexibility and its aberrations are key drivers of cancer progression. We identified an alternatively spliced exon cassette in myosin VI, an actin motor protein. In healthy epithelial tissues like the ovary and intestine, this exon cassette is …
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THE ALTERNATIVE SPLICING OF NF-YA REGULATES MOUSE EMBRYONIC STEM CELLS DIFFERENTIATION
… exists in two different isoforms generated by Alternative Splicing of Exon 3. The short (NF-YAs) and the long (NF-YAl) isoforms differ from a stretch of 28-29 amino acids in the N-terminal Q-rich activation domain. Although they display identical DNA-binding properties in vitro, the two …
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