Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Alternative oxidase"”.
-
The Role of Mitochondrial Alternative Oxidase in Plant-pathogen Interactions
Alternative oxidase (AOX) is a non-energy conserving branch of the mitochondrial electron transport chain (ETC) which has been hypothesized to modulate the level of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in plant mitochondria. The aim of the research presented herein is …
-
Small molecule inhibitors of parasitic enzymes
… anti-trypanosomal inhibitors of trypanosome alternative oxidase, and (ii) synthetic and methodological studies.
-
Zusammenhang zwischen dem Gärungsverhalten und dem Stickstoffmetabolismus in der Hefe Pichia stipitis
… identified as ubiquitin ligase and cytochrome-C-oxidase subunit V (COX5). The COX5 mutant was chosen for further characterization. This was done by determination of the substrate spectrum, measuring of the ethanol formation under different aeration conditions, and by testing the sensitivity to …
-
Identification and characterization of host genes involved in regulating replication of brome mosaic virus
… proteins, a lectin superfamily protein, and an alternative oxidase. My results also contribute to the growing evidence that reactive oxygen species play a key role in BMV replication. In summary, my work provided new insights into BMV replication in hosts and plant defense against BMV infection. …
-
Describing the Cell Biology of Saprolegnia parasitica: Role of Metals and Respiration
… bypass extracellular copper chelation through alternative uptake pathways or internal copper reservoirs. To assess mitochondrial function, we measured Saprolegnia parasitica oxygen consumption using a Clark-type oxygen electrode under varying growth conditions. BCS-treated S. parasitica …
-
Elucidating the mechanism of mitochondrial superoxide production in pro-inflammatory macrophages
… derived macrophages (BMDMs) expressing the alternative oxidase (AOX) to determine the influence of an oxidised CoQ pool on mitochondrial superoxide production. Using this approach, I demonstrated that LPS induced mitochondrial superoxide production is driven by an elevated proton motive …
-
Structure-function studies of respiratory complex I from Paracoccus denitrificans using membrane mimetics
… by ubiquinone cycling between complex I and an alternative oxidase. The suitability of the system for structural studies was demonstrated by determination of a 3.1 Å resting-state structure of the enzyme reconstituted in covalently circularized nanodiscs of predefined size, paving the way for …
-
Regulation of taproot development and sucrose stabilization in sugar beet: Influence of invertase inhibitors and occurrence of mitochondrial energy-dissipating proteins
… exprimiert, während eine Induktion einer alternativen Oxidase nach Verwundung und Lagerung beobachtet wurde. Mitglieder beider Genfamilien sind mögliche Zielgene, die Saccharoseverluste während der Lagerung beeinflussen können. Sie dienen als Energie-Ableitungssysteme und ihre Aktivität …
-
Investigating the rate-limiting step of mitochondrial complex I catalysis
Respiratory complex I (NADH:ubiquinone oxidoreductase) is a key enzyme in metabolism and is the least understood protein in the mitochondrial electron transfer chain (ETC). It couples the energy released from NADH oxidation and ubiquinone (Q) reduction to the translocation of four protons across …