Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Alternate Splicing"”.
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BMEA: Bayesian Modelling For Exon Array Data
… 3' Microarray technology, however detection of alternate splicing events proved challenging. In this work a novel method, Bayesian Modelling for Exon Arrays (BMEA), is described which shows an improvement in performance over previous approaches, and fits a more appropriate model for each gene …
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Site-directed mutagenesis of the ATP-binding site in spinach rubisco activase
… rubisco activase has two isoforms derived from alternate splicing with the larger polypeptide containing an additional 4 kD C-terminal domain. Both isoforms, with molecular masses of 41 kD and 45 kD, were synthesized and purified from the transformed E. coli containing the cDNAs. A significant …
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Towards a comprehensive human protein-protein interaction network
… to molecular complexity, tissue specificity, and alternate splicing. It therefore becomes important to build well-annotated benchmarks and accuracy measures to evaluate new data. Here, we describe three methods that provide a framework to build a comprehensive human interactome. We have developed …
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Characterization of Erbb4 Expression In Osteosarcoma
… ERBB4 is unique within the ERBB family for alternate splicing in its juxtamembrane and cytoplasmic regions, which produces four juxtamembrane isoforms and two cytoplasmic isoforms. The cleavable juxtamembrane isoforms, Jm-a and Jm-d, can undergo proteolytic cleavage and produce an 80-kDa …
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The transcription factors Pax-6 and X-dll3 influence visual and olfactory system development in Xenopus laevis
… Xenopus A and B transcripts are produced from an alternate splicing event that occurs in each of at least two Pax-6 genes existing in the Xenopus genome. Both A and B transcripts are expressed in brain and eye tissue. Antibodies generated against unique peptide sequences located in the …
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Local or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes and Downregulates c-MYC Oncoprotein
<p>The past decade has witnessed remarkable advances in the field of cancer immunotherapy. Immune checkpoint blockade (ICB) has emerged as a cornerstone, achieving long-lasting tumor regression in several types of cancer. However, its effectiveness is often limited, particularly in certain tumor …