Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Altered metabolism"”.
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Study of altered metabolism in cancer by high content SRS microscopy
Altered metabolism represents an Achilles' heel of cancer, offering opportunities for advanced diagnosis and treatment. However, studying cancer metabolism at the single-cell level remains challenging. Current methods are either destructive and provide only bulk analysis, like mass spectrometry, or …
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Altered Fuel Supply and Utilization in the Hypothalamus Following Recurrent Hypoglycemia
… local substrate concentrations in the VMH are altered by RH and are affected by glycogen availability and noradrenergic activity. The changes in local energy supply contribute to the impaired CRR seen in RH, supporting a role for altered metabolism in HAAF.
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Altered Ovarian Cancer Metabolism Increases Neuronal N-Acetylaspartate to Promote Tumor Growth
<p>Background: Altered metabolism is a well-established trait in many cancers, and is an emerging hallmark of cancer. Recent resurgence of cancer metabolism studies has identified dysregulated metabolic pathways that produce novel oncometabolites in various cancers. However, large scale studies of …
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Elucidating the Target and Selectivity of a Non-Small Cell Lung Cancer Toxin
… of aspartate formed via reductive glutamine metabolism promotes resistance to mitochondrial inhibition. Altered metabolism is an important feature of cancer and there is significant interest in understanding how differences in tumor metabolism can be exploited for therapy. NSCLC cells subject …
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INTERPLAY BETWEEN MDM2 AND TFAM REGULATES OXIDATIVE PHOSPHORYLATION IN DRUG-RESISTANT ONCOGENE-ADDICTED CANCERS
… we describe a novel observation that altered metabolism and TKI resistance in cancer cells could be mediated by MDM2 phosphorylation and mitochondria localization.
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Mitochondrial Metabolism Elucidated by Rapid Fractionation from Tissue
… metabolic hubs, with many diseases found to have altered metabolism and mitochondrial dysfunction, such as ischaemia-reperfusion injury. A detailed understanding of the metabolic changes in different cellular pools would aid diagnosis and treatment. However, the current methods of mitochondrial …
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Verlaufsuntersuchung zellulärer Immunparameter bei schizophrenen Patienten
… nonspecific stress reaction or an effect of the altered metabolism of neurotransmitters. On the other hand the observed changes in the immune system could be due to infectious diseases or autoimmune processes provoking the symptoms of schizophrenia.
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… stages, there is evidence of dysregulated metabolism present in these early lesions, including an increase in lactate production. The overarching goal of this dissertation is to develop the capability of non-invasively detecting these premalignant precursor lesions in the pancreas prior to …
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Effects of Polydatin on In Vitro Bovine Embryo Developmental Competence, Metabolism, and Cryopreservation
… suffer from poor developmental competence and altered metabolism which hinders their cryotolerance. Overall, the goals of this thesis were to improve oocyte and embryo culture with the antioxidant polydatin and to optimize slow freezing procedures. This thesis was designed as three experiments, …
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Understanding the reproductive biology of giant pandas: predictive biomarkers for reproductive success
… new reproductive biomarkers can be identified. Metabolism and reproduction are linked, with female giant pandas showing altered metabolism at key reproductive periods. Metabolism also influences urinary biomarker correction, and urinary specific gravity (USpG) has been identified as a …
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Mitochondrial genetic variation in the evolution of humans and metabolism of cancer
… genetic mutations was studied in the context of altered metabolism in cancer, where biosynthesis and maintenance of redox capacity is favoured over energy production via oxidative phosphorylation in tumour cells. 24 somatic mutations were identified in the mitochondrial genomes of 12 …
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Interaction between DVAP, the orthologue of human VAPB, and Drosophila Sac1
… starting point to identify the mechanism that is altered when DVAP function is impaired. Thus, the possibility that the cellular pathways regulated by PI4P are affected in VAPB-mediated neurodegeneration was explored. First, the Sac1-DVAP association was confirmed in vitro by …
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Interrogating Cancer Metabolism using Novel Imaging Techniques
Altered metabolism is one of the hallmarks of cancer and is known to enable the proliferation and survival of cancer cells in changing microenvironments. Metabolic changes can be interrogated using non-invasive metabolic imaging techniques, which enable the investigation of tumour metabolism in …
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Mathematical approaches for the clinical translation of hyperpolarised 13C imaging in oncology
… an emerging clinical technique which enables the metabolism of hyperpolarised 13C-labelled molecules to be dynamically and non- invasively imaged in tissue. The first molecule to gain clinical approval is [1-13C]pyruvate, the conversion of which to [1-13C]lactate has been shown to detect early …
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Investigating pseudohypoxia in renal cells deficient in fumarate hydratase.
… provided strong support for a primary role of altered metabolism in driving cancer. One of these enzymes, fumarate hydratase (FH), is found mutated in hereditary and leiomyomatosis and renal cell cancer syndrome, whereby affected cells are characterized by high subcellular accumulation of the …
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Benchmarking Biological Indices of Commercial Broiler Chickens Reared on Conventional and Alternative Gut Health Management Programs
… plasma metabolites and tibia attributes suggest altered metabolism possibly linked to gut health management programs and their ability to support gut integrity and function in the absence of antibiotics. Overall, birds reared on the gut health management programs did not show growth performance …
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The Effect of Age and Sex on Chemotherapy-Induced Cachexia and Branched-Chain Amino Acid Metabolism
… chemotherapy causes appetite loss, fatigue, altered metabolism and decreased physical activity, all contributing to muscle tissue breakdown and cachexia. Decades of research into investigating interventions to mitigate the effects of cachexia have been unsuccessful. Even the use of …
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The impact of different dietary patterns on nutritional status and metabolic integrity in asymptomatic people living with HIV infection in South Africa
… marked biochemical differences depicting altered metabolism and inflammation were observed in PLWH compared to the uninfected. PLWH also showed an anthropometric profile that depicted altered body composition and abnormal fat distribution. Four dietary patterns: animal-based, …
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The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype
… self-renewal via β-Catenin/c-Myc regulation of altered metabolism in the Claudin-low breast cancer subtype, a process which is dependent upon the scaffolding protein NEDD9 and the metabolic enzyme PKM2. Together, these data suggest that a combined biomarker of TGFβ signalling and c-Myc …
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Utilización combinada de técnicas analíticas y quimiométricas en lipidómica orientadas al descubrimiento de biomarcadores asociados a alteraciones en el metabolismo de lípidos
… of starting samples. The analysis of these altered samples irreversibly compromises the quality of the results that can be obtained from them. For this reason, one of the main objectives of this doctoral thesis is to provide clinical laboratories with a series of reliable protocols and …
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